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Ashish Gadicherla, PhD

Assistant Professor, Director, Oxford Instruments Center for Advanced Microscopy, EM Core Facility Interim Technical Director, Structural Biology Shared Resources, MCW Cancer Center

Locations

  • Cell Biology, Neurobiology & Anatomy

Contact Information

Education

Postdoctoral Fellow, Structural Biology, Max Planck Institute for Biophysics, Frankfurt, Germany
Marie Curie Postdoctoral Fellow, Cardiac Physiology and Imaging, Oslo University, Oslo, Norway
PhD in Biotechnology, Cardiac Physiology, Ghent University, Ghent, Belgium
Master of Science in Biological Sciences, Purdue University, Indiana
Bachelor of Technology, Biotechnology, JN Technological University, Hyderabad, India

Biography

I started my scientific career with Bachelor’s degree in biotechnology which was a perfect combination of engineering and biological sciences. Because of my interest in biology, I followed that up with my Masters in biological sciences at Purdue University. For a few following years, I worked at the Medical College of Wisconsin studying the role of mitochondrial respiratory complexes and ion channels in the lab of Dr. David Stowe and Dr. Amadou Camara.

I then went on to obtain my PhD from Ghent University, Belgium studying the role of mitochondrial Connexin 43 channels in cardiac ischemia reperfusion injury. As a part of these studies, I worked in the lab of Dr. Wai-Meng Kwok to use planar lipid bilayer electrophysiology technique to verify channel identity and its characteristics. Marie Curie Postdoctoral fellowship enabled me to study the role of microRNAs and extracellular matrix proteins in cardiac fibrosis at Oslo University, Norway. I then went on to do a second postdoctoral fellowship in structural biology at the Max Planck Institute for Biophysics where I was involved in the determination of structure of sodium and potassium gated ion channels with the help of cryo-electron tomography.

Throughout my scientific career, an underlying theme has been the use of different imaging modalities including confocal imaging, super resolution imaging and later electron microscopy including cryoEM. As the director of Oxford Instruments Center for Advanced Imaging- EM Core, and the Interim Technical Director of the Structural Biology Shared Resources, I am involved in supporting researchers’ imaging needs from optical imaging to cryoEM where I can use my knowledge and experience to understand their imaging needs and help them in this endeavor.

Publications