Michael T. Zimmermann, PhD

Publications

• Laboratory perspectives in the development of polygenic risk scores for disease: A points to consider statement of the American College of Medical Genetics and Genomics (ACMG).

  (Reddi HV, Wand H, Funke B, Zimmermann MT, Lebo MS, Qian E, Shirts BH, Zou YS, Zhang BM, Rose NC, Abu-El-Haija A, ACMG Laboratory Quality Assurance Committee. Electronic address: documents@acmg.net.) Genet Med. 2023 May;25(5):100804 PMID: 36971772 SCOPUS ID: 2-s2.0-85152941721 03/28/2023

• The splanchnic mesenchyme is the tissue of origin for pancreatic fibroblasts during homeostasis and tumorigenesis.

  (Han L, Wu Y, Fang K, Sweeney S, Roesner UK, Parrish M, Patel K, Walter T, Piermattei J, Trimboli A, Lefler J, Timmers CD, Yu XZ, Jin VX, Zimmermann MT, Mathison AJ, Urrutia R, Ostrowski MC, Leone G.) Nat Commun. 2023 Jan 03;14(1):1 PMID: 36596776 PMCID: PMC9810714 SCOPUS ID: 2-s2.0-85145429848 01/04/2023

• Priming therapy by targeting enhancer-initiated pathways in patient-derived pancreatic cancer cells

  (Fraunhoffer NA, Moreno Vega AI, Abuelafia AM, Morvan M, Lebarbier E, Mary-Huard T, Zimmermann M, Lomberk G, Urrutia R, Dusetti N, Blum Y, Nicolle R, Iovanna J.) eBioMedicine. June 2023;92 SCOPUS ID: 2-s2.0-85154565512 06/01/2023

• Erratum: Impact of integrated translational research on clinical exome sequencing (Genetics in Medicine (2021) 23(3) (498–507), (S1098360021049455), (10.1038/s41436-020-01005-9))

  (Klee EW, Cousin MA, Pinto e Vairo F, Morales-Rosado JA, Macke EL, Jenkinson WG, Ferrer A, Schultz-Rogers LE, Olson RJ, Oliver GR, Sigafoos AN, Schwab TL, Zimmermann MT, Urrutia RA, Kaiwar C, Gupta A, Blackburn PR, Boczek NJ, Prochnow CA, Lowy RJ, Mulvihill LA, McAllister TM, Aoudia SL, Kruisselbrink TM, Gunderson LB, Kemppainen JL, Fisher LJ, Tarnowski JM, Hager MM, Kroc SA, Bertsch NL, Agre KE, Jackson JL, Macklin-Mantia SK, Murphree MI, Rust LM, Summer Bolster JM, Beck SA, Atwal PS, Ellingson MS, Barnett SS, Rasmussen KJ, Lahner CA, Niu Z, Hasadsri L, Ferber MJ, Marcou CA, Clark KJ, Pichurin PN, Deyle DR, Morava-Kozicz E, Gavrilova RH, Dhamija R, Wierenga KJ, Lanpher BC, Babovic-Vuksanovic D, Farrugia G, Schimmenti LA, Stewart AK, Lazaridis KN.) Genetics in Medicine. February 2023;25(2) SCOPUS ID: 2-s2.0-85146870414 02/01/2023

• Gain and loss of TASK3 channel function and its regulation by novel variation cause KCNK9 imprinting syndrome.

  (Cousin MA, Veale EL, Dsouza NR, Tripathi S, Holden RG, Arelin M, Beek G, Bekheirnia MR, Beygo J, Bhambhani V, Bialer M, Bigoni S, Boelman C, Carmichael J, Courtin T, Cogne B, Dabaj I, Doummar D, Fazilleau L, Ferlini A, Gavrilova RH, Graham JM Jr, Haack TB, Juusola J, Kant SG, Kayani S, Keren B, Ketteler P, Klöckner C, Koopmann TT, Kruisselbrink TM, Kuechler A, Lambert L, Latypova X, Lebel RR, Leduc MS, Leonardi E, Lewis AM, Liew W, Machol K, Mardini S, McWalter K, Mignot C, McLaughlin J, Murgia A, Narayanan V, Nava C, Neuser S, Nizon M, Ognibene D, Park J, Platzer K, Poirsier C, Radtke M, Ramsey K, Runke CK, Guillen Sacoto MJ, Scaglia F, Shinawi M, Spranger S, Tan ES, Taylor J, Trentesaux AS, Vairo F, Willaert R, Zadeh N, Urrutia R, Babovic-Vuksanovic D, Zimmermann MT, Mathie A, Klee EW.) Genome Med. 2022 Jun 13;14(1):62 PMID: 35698242 PMCID: PMC9195326 SCOPUS ID: 2-s2.0-85131795908 06/14/2022

• To ChIP, or to CUT, that is the question: Comparative Evaluation of NextGen Methodologies for Studying the genome-wide distribution of Histone H3 Lysine 9 di-methyl mark in pancreatic cells.

  (Urrutia G, Abrudan JL, Du M, de Assuncao TM, Mathison AJ, Zimmermann MT, Lomberk G, Urrutia R.) FASEB J. 2022 May;36 Suppl 1 PMID: 35556470 SCOPUS ID: 2-s2.0-85130072518 05/14/2022

• Transcriptional Landscape Established by the Euchromatic Histone-lysine N-methyltransferase Pathway During Pancreas Ontogenesis and Pancreatitis.

  (Urrutia R, Salmonson A, Urrutia G, de Assuncao TM, Zimmermann MT, Mathison AJ, Lomberk G.) FASEB J. 2022 May;36 Suppl 1 PMID: 35556469 SCOPUS ID: 2-s2.0-85130010001 05/14/2022

• Defining the Mutational Landscape That Affects the Histone Demethylase KDM6A/UTX in Human Cancer.

  (Chi YI, Stodola TJ, de Assuncao TM, Volkman B, Smith B, Mathison AJ, Lomberk G, Zimmermann MT, Urrutia R.) FASEB J. 2022 May;36 Suppl 1 PMID: 35555661 SCOPUS ID: 2-s2.0-85130046941 05/14/2022

• Integrative Modeling, Molecular Mechanics, and Molecular Dynamics Evaluation of Genomics Variants in KMT2C (MLL3), a Gene Involved in Kleefstra Syndrome Type 2.

  (Jorge SD, Chi YI, de Assuncao TM, Mathison AJ, Volkman B, Smith B, Lomberk G, Zimmermann MT, Urrutia R.) FASEB J. 2022 May;36 Suppl 1 PMID: 35553749 SCOPUS ID: 2-s2.0-85130006059 05/14/2022

• Epigenomic mechanisms used by KrasG12D to regulate inflammatory gene clusters in epithelial pancreatic cancer cells, which are critical for reprogramming the tumor microenvironment.

  (Du M, Abrudan JL, Urrutia G, de Assuncao TM, Mathison AJ, Zimmermann MT, Lomberk G, Urrutia R.) FASEB J. 2022 May;36 Suppl 1 PMID: 35552230 SCOPUS ID: 2-s2.0-85130057842 05/14/2022

• Molecular Modeling is an Enabling Approach to Complement and Enhance Channelopathy Research.

  (Zimmermann MT.) Compr Physiol. 2022 Mar 29;12(2):3141-3166 PMID: 35578963 SCOPUS ID: 2-s2.0-85130059929 05/18/2022

• Structural bioinformatics enhances the interpretation of somatic mutations in KDM6A found in human cancers.

  (Chi YI, Stodola TJ, De Assuncao TM, Leverence EN, Smith BC, Volkman BF, Mathison AJ, Lomberk G, Zimmermann MT, Urrutia R.) Comput Struct Biotechnol J. 2022;20:2200-2211 PMID: 35615018 PMCID: PMC9111933 SCOPUS ID: 2-s2.0-85130080827 05/27/2022