About Regenerative Engineered Biomaterials Lab Research
The REB Lab studies how multiple classes of regenerative biomaterials interact with their respective target environment. We then create engineering solutions to mitigate these interactions and shortfalls for various medical devices. We study engineering devices made from bioabsorbable polymers, bioabsorbable metals, and cell-derived materials. Ultimately, we aim to apply these materials in a combinatorial (or composite) fashion to provide the next generation of regenerative materials for a variety of clinical applications.
The ROS/RNS Balance of Bioabsorbable Materials
In this ongoing project, the REB Lab will explore how the complex biodegradation and bio-absorption process of bioabsorbable metals modulate the complex ROS/RNS generation axis in vitro and in vivo.
Representative Publication
Deciphering the Relationship Between Bioresorbable Magnesium Alloy Corrosion and the Inflammatory Microenvironment of the Neointima
The objectives of this project are twofold. First, we seek to clarify how physiologically relevant atherosclerotic inflammatory mirco-environments within the neointima affect the corrosion progression of magnesium-based materials. Second, we will work to determine whether magnesium corrosion can exert measurable changes in the progression of the neointima. To accomplish this, we will be using advanced elemental imaging and large-scale data collection in an APEO-/- KO mouse model.
Representative Publication
Engineering Bioabsorbable Flow Diverters
In this collaborative effort, the REB Lab aims to design, build and test novel bioabsorbable flow diverters for neurovascular applications.