Benjamin Gantner, PhD

Assistant Professor

Locations

Endocrinology and Molecular Medicine

Contact Information

Research Interests

Dr. Gantner is interested in studying different types of inflammatory responses to understand how they impact the decisions of innate immune cells (e.g. macrophages and neutrophils) to injure surrounding host tissue. The lab uses microscopic observation of cells in living animals (i.e. intravital imaging) and in vitro culture systems to study the intracellular processes, intercellular communications, and behavioral responses of immune cells during bacterial infection and cancer.

Leadership Positions

MCW Internal

Vice Chair, Institutional Biosafety Committee

Histone H3.1 is a chromatin-embedded redox sensor triggered by tumor cells developing adaptive phenotypic plasticity and multidrug resistance.

(Palma FR, Coelho DR, Pulakanti K, Sakiyama MJ, Huang Y, Ogata FT, Danes JM, Meyer A, Furdui CM, Spitz DR, Gomes AP, Gantner BN, Rao S, Backman V, Bonini MG.) Cell Rep. 2024 Mar 26;43(3):113897 PMID: 38493478 PMCID: PMC11209755 SCOPUS ID: 2-s2.0-85188001867 03/17/2024
ROS production by mitochondria: function or dysfunction?

(Palma FR, Gantner BN, Sakiyama MJ, Kayzuka C, Shukla S, Lacchini R, Cunniff B, Bonini MG.) Oncogene. 2024 Jan;43(5):295-303 PMID: 38081963 SCOPUS ID: 2-s2.0-85179332430 12/12/2023
SOCS1 regulates a subset of NFκB-target genes through direct chromatin binding and defines macrophage functional phenotypes.

(Coelho DR, Palma FR, Paviani V, LaFond KM, Huang Y, Wang D, Wray B, Rao S, Yue F, Bonini MG, Gantner BN.) iScience. 2023 Apr 21;26(4):106442 PMID: 37020964 PMCID: PMC10068561 SCOPUS ID: 2-s2.0-85151424842 04/07/2023
Collagen-Specific HSP47+ Myofibroblasts and CD163+ Macrophages Identify Profibrotic Phenotypes in Deceased Hearts With SARS-CoV-2 Infections.

(Puzyrenko A, Jacobs ER, Padilla N, Devine A, Aljadah M, Gantner BN, Pan AY, Lai S, Dai Q, Rubenstein JC, North PE, Simpson PM, Willoughby RE, O'Meara CC, Flinn MA, Lough JW, Ibrahim EH, Zheng Z, Sun Y, Felix J, Hunt BC, Ross G, Rui H, Benjamin IJ.) J Am Heart Assoc. 2023 Feb 21;12(4):e027990 PMID: 36789856 PMCID: PMC10111490 SCOPUS ID: 2-s2.0-85148479620 02/16/2023
Pcpe2, a Novel Extracellular Matrix Protein, Regulates Adipocyte SR-BI-Mediated High-Density Lipoprotein Uptake.

(Xu H, Thomas MJ, Kaul S, Kallinger R, Ouweneel AB, Maruko E, Oussaada SM, Jongejan A, Cense HA, Nieuwdorp M, Serlie MJ, Goldberg IJ, Civelek M, Parks BW, Lusis AJ, Knaack D, Schill RL, May SC, Reho JJ, Grobe JL, Gantner B, Sahoo D, Sorci-Thomas MG.) Arterioscler Thromb Vasc Biol. 2021 Nov;41(11):2708-2725 PMID: 34551590 PMCID: PMC8551036 SCOPUS ID: 2-s2.0-85118592107 09/24/2021
Pneumocytes are distinguished by highly elevated expression of the ER stress biomarker GRP78, a co-receptor for SARS-CoV-2, in COVID-19 autopsies.

(Puzyrenko A, Jacobs ER, Sun Y, Felix JC, Sheinin Y, Ge L, Lai S, Dai Q, Gantner BN, Nanchal R, North PE, Simpson PM, Rui H, Benjamin IJ.) Cell Stress Chaperones. 2021 Sep;26(5):859-868 PMID: 34382151 PMCID: PMC8357488 SCOPUS ID: 2-s2.0-85112285201 08/13/2021
Inorganic arsenic promotes luminal to basal transition and metastasis of breast cancer.

(Danes JM, de Abreu ALP, Kerketta R, Huang Y, Palma FR, Gantner BN, Mathison AJ, Urrutia RA, Bonini MG.) FASEB J. 2020 Dec;34(12):16034-16048 PMID: 33047385 PMCID: PMC8289339 SCOPUS ID: 2-s2.0-85092336914 10/14/2020
Nitric oxide in cellular adaptation and disease.

(Gantner BN, LaFond KM, Bonini MG.) Redox Biol. 2020 Jul;34:101550 PMID: 32438317 PMCID: PMC7235643 SCOPUS ID: 2-s2.0-85084644297 05/22/2020
Acquired Immunity Is Not Essential for Radiation-Induced Heart Dysfunction but Exerts a Complex Impact on Injury.

(Schlaak RA, Frei A, Fish BL, Harmann L, Gasperetti T, Pipke JL, Sun Y, Rui H, Flister MJ, Gantner BN, Bergom C.) Cancers (Basel). 2020 Apr 16;12(4) PMID: 32316187 PMCID: PMC7226421 04/23/2020
Mitochondrial Superoxide Dismutase: What the Established, the Intriguing, and the Novel Reveal About a Key Cellular Redox Switch.

(Palma FR, He C, Danes JM, Paviani V, Coelho DR, Gantner BN, Bonini MG.) Antioxid Redox Signal. 2020 Apr 01;32(10):701-714 PMID: 31968997 PMCID: PMC7047081 SCOPUS ID: 2-s2.0-85081092325 01/24/2020
Nitric oxide in cellular adaptation and disease

(Gantner BN, LaFond KM, Bonini MG.) Redox Biology. July 2020;34 SCOPUS ID: 2-s2.0-85084644297 07/01/2020