
Anthony E. Zamora, PhD
Assistant Professor, Medicine (Hematology and Oncology) and Microbiology & Immunology
Locations
- MFRC 6072
Contact Information
Education
Research Experience
- Antigen Presentation
- CD8-Positive T-Lymphocytes
- Cell Engineering
- Disease Models, Animal
- Flow Cytometry
- Immunity
- immunology
- Immunotherapy
- Killer Cells, Natural
- Leukemia, B-Cell
- Single-Cell Analysis
- T-Lymphocytes
Research Interests
Research in the Zamora lab spans the fields of viral and cancer immunology, with a special focus on identifying ways to modulate the immune system to more effectively target and eliminate virally infected or cancerous cells. Along these lines, the lab utilizes cellular-based engineering approaches that aim to increase the specificity of immune cells for their targets and at the same time decrease the likelihood of off-target toxicities. A longstanding goal in the lab has also been to help address the current disparities in cancer research by developing reagents, assays, and tools that provide a deeper understanding of the underlying mechanisms that govern antitumor immunity across diverse demographic groups.
Current research in the Zamora lab focuses on: (1) discovering tumor antigens that serve as immunogenic targets, (2) identifying the mechanisms involved in the immune system’s ability to generate antitumor specificities, (3) characterizing the phenotypic, functional, and receptor repertoires of NK cells and neoantigen-specific T cells, and (4) exploring ways to translate these findings in order to expand on the current therapeutic options used to treat cancer.
Publications
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Simulating the Evolution of Signaling Signatures during CART-Cell -- Tumor Cell Interactions.
(Shah V, Womack J, Zamora AE, Terhune SS, Dash RK.) ArXiv. 2023 Feb 08 PMID: 36798455 PMCID: PMC9934731 02/18/2023
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(Moustaki A, Crawford JC, Alli S, Fan Y, Boi S, Zamora AE, McDonald NMN, Wu G, Nakitandwe J, Newman S, Foy S, Silkov A, Thomas PG, Pappo A, Dyer MA, Stewart E, Federico S, Youngblood B.) Sci Immunol. 2022 Feb 04;7(68):eabf6136 PMID: 35119937 PMCID: PMC8990347 SCOPUS ID: 2-s2.0-85124175298 02/05/2022
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Activation status dictates the function of unlicensed natural killer cells in mice and humans.
(Aguilar EG, Dunai C, Judge SJ, Zamora AE, Khuat LT, Vick LV, Collins CP, Stoffel KM, Alvarez M, Barao I, Miller JS, Blazar BR, Chevallier P, Retiere C, Canter RJ, Murphy WJ.) Blood Adv. 2021 Oct 26;5(20):4219-4232 PMID: 34496010 PMCID: PMC8945636 SCOPUS ID: 2-s2.0-85118595142 09/09/2021
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Tumor-intrinsic and -extrinsic determinants of response to blinatumomab in adults with B-ALL.
(Zhao Y, Aldoss I, Qu C, Crawford JC, Gu Z, Allen EK, Zamora AE, Alexander TB, Wang J, Goto H, Imamura T, Akahane K, Marcucci G, Stein AS, Bhatia R, Thomas PG, Forman SJ, Mullighan CG, Roberts KG.) Blood. 2021 Jan 28;137(4):471-484 PMID: 32881995 PMCID: PMC7845009 SCOPUS ID: 2-s2.0-85099973176 09/04/2020
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(Zamora AE, Crawford JC, Allen EK, Guo XJ, Bakke J, Carter RA, Abdelsamed HA, Moustaki A, Li Y, Chang TC, Awad W, Dallas MH, Mullighan CG, Downing JR, Geiger TL, Chen T, Green DR, Youngblood BA, Zhang J, Thomas PG.) Sci Transl Med. 2019 Jun 26;11(498) PMID: 31243155 PMCID: PMC7020562 SCOPUS ID: 2-s2.0-85068363631 06/28/2019
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Genome-wide CRISPR screen reveals PSMA6 to be an essential gene in pancreatic cancer cells.
(Bakke J, Wright WC, Zamora AE, Oladimeji P, Crawford JC, Brewer CT, Autry RJ, Evans WE, Thomas PG, Chen T.) BMC Cancer. 2019 Mar 21;19(1):253 PMID: 30898113 PMCID: PMC6429770 SCOPUS ID: 2-s2.0-85063331223 03/23/2019
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(Guo XJ, Dash P, Crawford JC, Allen EK, Zamora AE, Boyd DF, Duan S, Bajracharya R, Awad WA, Apiwattanakul N, Vogel P, Kanneganti TD, Thomas PG.) Immunity. 2018 Sep 18;49(3):531-544.e6 PMID: 30170813 PMCID: PMC6345262 SCOPUS ID: 2-s2.0-85055586852 09/02/2018
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Hitting the Target: How T Cells Detect and Eliminate Tumors.
(Zamora AE, Crawford JC, Thomas PG.) J Immunol. 2018 Jan 15;200(2):392-399 PMID: 29311380 PMCID: PMC6116355 SCOPUS ID: 2-s2.0-85044719192 01/10/2018
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Transcription factor ZNF148 is a negative regulator of human muscle differentiation.
(Bakke J, Wright WC, Zamora AE, Ong SS, Wang YM, Hoyer JD, Brewer CT, Thomas PG, Chen T.) Sci Rep. 2017 Aug 15;7(1):8138 PMID: 28811660 PMCID: PMC5557752 SCOPUS ID: 2-s2.0-85027508922 08/16/2017
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(Allen EK, Randolph AG, Bhangale T, Dogra P, Ohlson M, Oshansky CM, Zamora AE, Shannon JP, Finkelstein D, Dressen A, DeVincenzo J, Caniza M, Youngblood B, Rosenberger CM, Thomas PG.) Nat Med. 2017 Aug;23(8):975-983 PMID: 28714988 PMCID: PMC5702558 SCOPUS ID: 2-s2.0-85029295000 07/18/2017
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Licensing delineates helper and effector NK cell subsets during viral infection.
(Zamora AE, Aguilar EG, Sungur CM, Khuat LT, Dunai C, Lochhead GR, Du J, Pomeroy C, Blazar BR, Longo DL, Venstrom JM, Baumgarth N, Murphy WJ.) JCI Insight. 2017 May 18;2(10) PMID: 28515356 PMCID: PMC5436543 SCOPUS ID: 2-s2.0-85034247888 05/19/2017
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Cell-Intrinsic Barriers of T Cell-Based Immunotherapy.
(Ghoneim HE, Zamora AE, Thomas PG, Youngblood BA.) Trends Mol Med. 2016 Dec;22(12):1000-1011 PMID: 27825667 PMCID: PMC5135632 SCOPUS ID: 2-s2.0-84999792425 11/09/2016