Xiao Chen, MD | Associate Professor | Medical College of Wisconsin

Xiao Chen, MD, PhD

Associate Professor

Locations

Medical College of Wisconsin
Department of Medicine
Division of Hematology and Oncology

Biography

Dr. Xiao Chen is Associate Professor of Medicine at the Medical College of Wisconsin, Division of Hematology and Oncology. He obtained his medical degree from Fujian Medical University in China and PhD degree in immunology from the Technical University of Dresden in Germany.

Research Interests

Dr. Chen has a long-standing commitment to hematological and immunological research with a particular interest and expertise in graft-versus-host disease (GVHD). Allogeneic hematopoietic stem cell transplantation (HSCT) is a life-saving treatment for many hematological malignancies. Each year, thousands of patients diagnosed with leukemia, lymphoma, and multiple myeloma will depend on a stem cell transplant for a second chance at life. Unfortunately, GVHD remains a serious and frequently fatal complication following allogeneic HSCT. The long term research goal of Dr. Chen’s lab is to find ways to augment the beneficial graft-versus-leukemia (GVL) effect while minimizing GVHD in order to make allogeneic HSCT a more effective and safer treatment for cancer patients. One of research projects in the lab has focused on how micronutrients such as vitamin A and vitamin D regulate GVHD risk after allogeneic HSCT. Ongoing research uses genetic, dietary, and pharmacological approaches to explore novel strategies to prevent and treat GVHD without compromising the GVL effect by targeting the retinoic acid receptor (RAR) and vitamin D receptor (VDR) signaling pathways. Dr. Chen also has a strong interest in tumor immunology and cellular immunotherapy.

Kras-Deficient T Cells Attenuate Graft-versus-Host Disease but Retain Graft-versus-Leukemia Activity.

(Luo L, Chen Y, Chen X, Zheng Y, Zhou V, Yu M, Burns R, Zhu W, Fu G, Felix JC, Hartley C, Damnernsawad A, Zhang J, Wen R, Drobyski WR, Gao C, Wang D.) J Immunol. 2020 12 15;205(12):3480-3490 PMID: 33158956 PMCID: PMC7955895 SCOPUS ID: 2-s2.0-85097490484 11/08/2020
Nuclear Receptors as Potential Therapeutic Targets for Myeloid Leukemia.

(Pan P, Chen X.) Cells. 2020 08 19;9(9) PMID: 32824945 PMCID: PMC7563802 SCOPUS ID: 2-s2.0-85089806628 08/23/2020
Radiation and host retinoic acid signaling promote the induction of gut-homing donor T cells after allogeneic hematopoietic stem cell transplantation.

(Zheng J, Taylor B, Dodge J, Stephans A, Zheng SG, Chen Q, Chen X.) Am J Transplant. 2020 01;20(1):64-74 PMID: 31207088 PMCID: PMC6918002 SCOPUS ID: 2-s2.0-85069712148 06/18/2019
All trans-retinoic acid protects against acute ischemic stroke by modulating neutrophil functions through STAT1 signaling.

(Cai W, Wang J, Hu M, Chen X, Lu Z, Bellanti JA, Zheng SG.) J Neuroinflammation. 2019 Aug 31;16(1):175 PMID: 31472680 PMCID: PMC6717357 SCOPUS ID: 2-s2.0-85071686674 09/02/2019
Loss of FFAR2 promotes colon cancer by epigenetic dysregulation of inflammation suppressors.

(Pan P, Oshima K, Huang YW, Agle KA, Drobyski WR, Chen X, Zhang J, Yearsley MM, Yu J, Wang LS.) Int J Cancer. 2018 08 15;143(4):886-896 PMID: 29524208 PMCID: PMC6041131 SCOPUS ID: 2-s2.0-85044521158 03/11/2018
The Role of Micronutrients in Graft-VS.-Host Disease: Immunomodulatory Effects of Vitamins A and D.

(Chen X, Mayne CG.) Front Immunol. 2018;9:2853 PMID: 30574143 PMCID: PMC6291446 SCOPUS ID: 2-s2.0-85058870758 12/24/2018
Role of Vitamin A in Modulating Graft-versus-Host Disease.

(Zheng J, Taylor B, Chen X.) J Immunol Res Ther. 2018;3(1):124-128 PMID: 30101210 PMCID: PMC6086377 08/14/2018
Loss of free fatty acid receptor 2 enhances colonic adenoma development and reduces the chemopreventive effects of black raspberries in ApcMin/+ mice.

(Pan P, W Skaer C, Wang HT, Oshima K, Huang YW, Yu J, Zhang J, M Yearsley M, A Agle K, R Drobyski W, Chen X, Wang LS.) Carcinogenesis. 2017 01;38(1):86-93 PMID: 27866157 PMCID: PMC5219051 SCOPUS ID: 2-s2.0-85027864388 11/21/2016
Effects of Donor Vitamin A Deficiency and Pharmacologic Modulation of Donor T Cell Retinoic Acid Pathway on the Severity of Experimental Graft-versus-Host Disease.

(Dodge J, Stephans A, Lai J, Drobyski WR, Chen X.) Biol Blood Marrow Transplant. 2016 12;22(12):2141-2148 PMID: 27596131 SCOPUS ID: 2-s2.0-85003032776 09/07/2016
A colitogenic memory CD4+ T cell population mediates gastrointestinal graft-versus-host disease.

(Zhou V, Agle K, Chen X, Beres A, Komorowski R, Belle L, Taylor C, Zhu F, Haribhai D, Williams CB, Verbsky J, Blumenschein W, Sadekova S, Bowman E, Ballantyne C, Weaver C, Serody DA, Vincent B, Serody J, Cua DJ, Drobyski WR.) J Clin Invest. 2016 09 01;126(9):3541-55 PMID: 27500496 PMCID: PMC5004941 SCOPUS ID: 2-s2.0-84987784902 08/09/2016
A critical role for the retinoic acid signaling pathway in the pathophysiology of gastrointestinal graft-versus-host disease.

(Chen X, Dodge J, Komorowski R, Drobyski WR.) Blood. 2013 May 09;121(19):3970-80 PMID: 23529927 PMCID: PMC3650708 SCOPUS ID: 2-s2.0-84880458648 03/27/2013
Role of Th17 Cells and Interleukin 17 in Graft-versus-host Disease and Graft-versus-leukemia Reactivity

(Chen X, Drobyski WR.) Immune Biology of Allogeneic Hematopoietic Stem Cell Transplantation. 2013:271-297 SCOPUS ID: 2-s2.0-84882596384 08/27/2013

Hematology and Oncology

Xiao Chen, MD, PhD

Associate Professor

Locations

Biography

Research Interests

Publications