Joseph T. Barbieri, PhD
Professor, Microbiology & Immunology; Associate Director, Medical Scientist Training Program
Locations
- Microbiology & Immunology
BSB B2830
Contact Information
General Interests
Education
Research Interests
My laboratory studies the molecular basis of microbial pathogenesis in Cellular Microbiology where components of the pathogen and host are analyzed to understand the pathogenic process. My research involves the study of bacterial toxins. Several families of bacterial toxins are under investigation: botulinum and tetanus neurotoxins; Certhrax, an ADP-ribosylating exotoxin from Bacillus cereus; and ExoS, a type III cytotoxin of Pseudomonas aeruginosa.
Publications
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Nontoxic, multi-domain botulinum neurotoxin-LCHCN as vaccines against botulism.
(Przedpelski A, Tepp WH, Gupta S, Barbieri JT, Pellett S.) Vaccine. 2025 Oct 24;65:127779 PMID: 40997375 SCOPUS ID: 2-s2.0-105019270072 09/25/2025
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(Gardner A, Sneller M, Tepp WH, Barbieri JT, Pellett S.) Commun Biol. 2025 Sep 29;8(1):1383 PMID: 41023315 PMCID: PMC12480579 SCOPUS ID: 2-s2.0-105017790990 09/30/2025
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Potency Evaluations of Recombinant Botulinum Neurotoxin A1 Mutants Designed to Reduce Toxicity.
(Viravathana P, Tepp WH, Bradshaw M, Przedpelski A, Barbieri JT, Pellett S.) Int J Mol Sci. 2024 Aug 17;25(16) PMID: 39201641 PMCID: PMC11355004 SCOPUS ID: 2-s2.0-85202686500 08/31/2024
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Testing a Recombinant Form of Tetanus Toxoid as a Carrier Protein for Glycoconjugate Vaccines.
(Oldrini D, Di Benedetto R, Carducci M, De Simone D, Massai L, Alfini R, Galli B, Brunelli B, Przedpelski A, Barbieri JT, Rossi O, Giannelli C, Rappuoli R, Berti F, Micoli F.) Vaccines (Basel). 2023 Nov 28;11(12) PMID: 38140177 PMCID: PMC10747096 12/23/2023
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(Tepp WH, Bradshaw M, Gardner AP, Kaufman RL, Barbieri JT, Pellett S.) Int J Mol Sci. 2023 Mar 16;24(6) PMID: 36982762 PMCID: PMC10055998 SCOPUS ID: 2-s2.0-85151111423 03/30/2023
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Light Chain Role in Action of Botulinum Toxins/Clostridial Neurotoxins
(Gardner A, Barbieri JT.) Handbook of Neurotoxicity Second Edition. 1 January 2023;2:1145-1154 SCOPUS ID: 2-s2.0-85153667632 01/01/2023
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(Gardner AP, Barbieri JT, Pellett S.) Toxins (Basel). 2022 Nov 22;14(12) PMID: 36548711 PMCID: PMC9783275 SCOPUS ID: 2-s2.0-85144580787 12/23/2022
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Genetically detoxified tetanus toxin as a vaccine and conjugate carrier protein.
(Chang MJ, Ollivault-Shiflett M, Schuman R, Ngoc Nguyen S, Kaltashov IA, Bobst C, Rajagopal SP, Przedpelski A, Barbieri JT, Lees A.) Vaccine. 2022 Aug 19;40(35):5103-5113 PMID: 35871872 PMCID: PMC10336728 SCOPUS ID: 2-s2.0-85134728035 07/26/2022
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(Yang C, Barbieri JT, Dahms NM, Chen C.) Biochemistry. 2022 Apr 05;61(7):616-624 PMID: 35285627 PMCID: PMC9817067 SCOPUS ID: 2-s2.0-85127145605 03/15/2022
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Bacterial toxins in disease production
(Barbieri JT, Pederson KJ.) Virulence Mechanisms of Bacterial Pathogens. 1 June 2022:163-174 SCOPUS ID: 2-s2.0-0008571823 06/01/2022
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(Gardner A, Tepp WH, Bradshaw M, Barbieri JT, Pellett S.) Int J Mol Sci. 2021 Oct 15;22(20) PMID: 34681775 PMCID: PMC8539409 SCOPUS ID: 2-s2.0-85116984877 10/24/2021
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Resolving the Molecular Steps in Clostridial Neurotoxin Light Chain Translocation.
(Zuverink M, Barbieri JT.) J Exp Neurol. 2020;1(4):123-134 PMID: 33615314 PMCID: PMC7894615 02/23/2021