Research Bench Lab
Michael Dwinell, PhD

Michael B. Dwinell, PhD

Professor; Founding Director, Center for Immunology; Director, Bobbie Nick Voss Laboratory for Colon Cancer Research; Leader, Molecular Cancer Therapeutics

Locations

  • Microbiology & Immunology
    TBRC C3860

Contact Information

General Interests

Cancer Metastasis, Tumor Microenvironment, Mucosal Inflammation

Education

PhD, GI Pathophysiology, University of Wisconsin, Madison, 1996

Research Experience

  • Carcinoma
  • Carcinoma, Pancreatic Ductal
  • Cell Line, Tumor
  • Cell Movement
  • Cell Proliferation
  • Chemokines
  • Cytokines
  • Energy Metabolism
  • Immunity, Mucosal
  • Immuno-Oncology
  • Mice
  • Mice, Knockout

Research Interests

Research in the Dwinell laboratory seeks to define the role for extracellular mediators in the progression and metastasis of solid and hematological cancers. Additional studies are examining the role for metabolic reprogramming to influence tumor progression and exploring new mitochondria-targeted compounds as inhibitors of cancer progression. Human and murine 2D and 3D cell culture systems and preclinical models are being used to investigate the cellular, biochemical, and metabolic signaling pathways that regulate cellular proliferation, programmed cell death and motility in inflammation and cancer. Pharmacokinetic / pharmacodynamics, toxicity and potency / efficacy studies following treatment with small molecule or biologic compounds are also being completed. These translational research studies are multidisciplinary and include molecular cloning, cell culture, biochemical assays and signal processing, histopathology, flow cytometry, and small animal imaging and handling. Completion of these studies will strengthen our identification of new targets for therapeutic intervention to improve human health.to improve human health.

Publications