Research Bench Lab

Dwinell Laboratory

Location

Microbiology & Immunology

TBRC C3860

General Interests

Cancer Progression and the Tumor Immune Microenvironment

View Michael B. Dwinell Bio
Michael Dwinell Laboratory
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Research Areas

Research in the Dwinell laboratory seeks to define the role for extracellular mediators in the progression and metastasis of solid and hematological cancers. Additional studies are examining the role for metabolic reprogramming to influence tumor progression and exploring new mitochondria-targeted compounds as inhibitors of cancer progression. Human and murine 2D and 3D cell culture systems and preclinical models are being used to investigate the cellular, biochemical, and metabolic signaling pathways that regulate cellular proliferation, programmed cell death and motility in inflammation and cancer. Pharmacokinetic / pharmacodynamics, toxicity and potency / efficacy studies following treatment with small molecule or biologic compounds are also being completed. These translational research studies are multidisciplinary and include molecular cloning, cell culture, biochemical assays and signal processing, histopathology, flow cytometry, and small animal imaging and handling. Completion of these studies will strengthen our identification of new targets for therapeutic intervention to improve human health.

Research Support

Research in the Dwinell laboratory is supported through grants from the National Institutes of Health, long standing support from the Bobby Nick Voss Charitable Foundation, the Medical College of Wisconsin Cancer Center and philanthropic donations.

Current Members

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Donna McAllister

Lab Supervisor

dmcallis@mcw.edu

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Kathleen Boyle, PhD

Adjunct Assistant Professor

kboyle@mcw.edu

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Nicholas Barnekow

Research Technologist II

nbarnekow@mcw.edu

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Laura McOlash

Research Technologist III

lmcolash@mcw.edu

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Mahmoud Abu Eid

Graduate Student

mabueid@mcw.edu

Recent Publications

Lab Alumni

Hong Guan, MS

Doctoral Candidate, Department of Chemistry and Biochemistry, University of South Carolina

 

Ishan Roy, MD, PhD

Clinical Instructor & Chief Resident Physician; Department of Physical Medicine & Rehabilitation, Northwestern University/Shirley Ryan Ability Lab

 

Natasha Moussouras, PhD

Research Fellow, Department of Microbiology & Immunology, Medical College of Wisconsin

 

Emily Vonderhaar, PhD

Clinical Research Training Fellow, Department of Microbiology & Immunology, Medical College of Wisconsin

 

Jonathan D. Van Wickle

Resident, Radiation Oncology, University of Iowa

 

Eric A. Luedke, MD

General Surgery, Sharp Memorial Hospital, Stanford Health Care-Stanford Hospital, San Diego, CA.

 

Yana Thaker, MD

General Internal Medicine, Gastroenterology, University of Washington, Seattle, WA

 

Joanne P Boisvert (Hayes), MD

Family Medicine Practice, Madras, OR

 

Egal I. Gorse, MD

2018- Fellowship Hematology and Medical Oncology, Emory University School of Medicine 2020 Recipient Nell W. and William Simpson Elkin Fellowship

 

Kimberle A Agle. PhD

Scientist-II, Immucor, Inc, Waukesha, WI

 

Amanda N. Cooper, MD

Private Practice, Dermatology, Germantown, WI

 

Luke J. Drury, PhD

Human Molecular Geneticist, Prevention Genetics, Marshfield Clinic, Marshfield, WI

 

Sheena L. Faherty

Science Writer, National Human Genome Research Institute (NHGRI), National Institutes of Health (NIH), Bethesda, MD

 

Soonyean Hwang, PhD

Postdoctoral Fellow, Dana-Farber Cancer Institute, Harvard Cancer Center, Mentor: Martin E. Hemler, PhD

 

Priscilla A. Johanesen, PhD

Associate Professor (Tenured), Deputy Head of Department (Education), Department of Microbiology, Monash University, Melbourne, AUSTRALIA

 

Jennifer M. Boardman (Smith), PhD

Assistant Dean for Academic Affairs for the School of Graduate Studies, Associate Professor, Microbiology and Immunology, Department of Basic Sciences, Geisinger

 

Rebecca A. Vongsa, PhD

Scientist-III, Kimberly-Clark Corp., Skin Health and Infection Control Health Care Division, Appleton, WI

 

Michael K. Wendt, PhD

Associate Professor, Purdue University, Lafayette, IN

 

Noah P. Zimmerman, PhD

Research Manager, Arm and Hammer, Waukesha, WI