Dwinell Laboratory
Location
Microbiology & Immunology
TBRC C3860
General Interests
Cancer Progression and the Tumor Immune Microenvironment
View Michael B. Dwinell BioResearch Areas
My research has been investigating the cellular, biochemical, molecular and pathophysiologic mechanisms controlling cellular movement in inflammation and cancer. The movement of cells within and between tissues is a fundamental property of biology. Cell movement / migration, may have beneficial effects, for example in wound healing or leukocyte trafficking, or deleterious effects, such as in the invasion and metastasis of tumor cells. My laboratory uses a spectrum of cellular, molecular, metabolomic and biochemical techniques, in combination with an array of cell culture and preclinical transgenic mouse models, to dissect the details of how cells move and the functional consequences of that movement. As chemokines are the archetype immune molecules directing cell movement, the investigative focus of my research program is to resolve the mechanisms of chemokine signaling in order to improve human health through the design of new chemokine-targeted or immune targeted therapies to disrupt or promote cellular movement in inflammation and cancer.
Research Support
Current Members









Recent Publications
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(Jørgensen AS, Brandum EP, Mikkelsen JM, Orfin KA, Boilesen DR, Egerod KL, Moussouras NA, Vilhardt F, Kalinski P, Basse P, Chen YH, Yang Z, Dwinell MB, Volkman BF, Veldkamp CT, Holst PJ, Lahl K, Goth CK, Rosenkilde MM, Hjortø GM.) Cell Mol Life Sci. 2021 Nov;78(21-22):6963-6978 PMID: 34586443 PMCID: PMC8558179 SCOPUS ID: 2-s2.0-85116031161 09/30/2021
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(Geethadevi A, Nair A, Parashar D, Ku Z, Xiong W, Deng H, Li Y, George J, McAllister DM, Sun Y, Kadamberi IP, Gupta P, Dwinell MB, Bradley WH, Rader JS, Rui H, Schwabe RF, Zhang N, Pradeep S, An Z, Chaluvally-Raghavan P.) Cancer Res. 2021 10 15;81(20):5336-5352 PMID: 34380633 PMCID: PMC8530981 SCOPUS ID: 2-s2.0-85116424540 08/13/2021
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(AbuEid M, McAllister DM, McOlash L, Harwig MC, Cheng G, Drouillard D, Boyle KA, Hardy M, Zielonka J, Johnson BD, Hill RB, Kalyanaraman B, Dwinell MB.) iScience. 2021 Jun 25;24(6):102653 PMID: 34189432 PMCID: PMC8220235 07/01/2021
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Targeting PIM1-Mediated Metabolism in Myeloid Suppressor Cells to Treat Cancer.
(Xin G, Chen Y, Topchyan P, Kasmani MY, Burns R, Volberding PJ, Wu X, Cohn A, Chen Y, Lin CW, Ho PC, Silverstein R, Dwinell MB, Cui W.) Cancer Immunol Res. 2021 04;9(4):454-469 PMID: 33579728 PMCID: PMC8137571 SCOPUS ID: 2-s2.0-85104420312 02/14/2021
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(Parashar D, Geethadevi A, McAllister D, Ebben J, Peterson FC, Jensen DR, Bishop E, Pradeep S, Volkman BF, Dwinell MB, Chaluvally-Raghavan P, James MA.) NPJ Precis Oncol. 2021 Mar 02;5(1):16 PMID: 33654182 PMCID: PMC7925570 SCOPUS ID: 2-s2.0-85109651282 03/04/2021
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(Urrutia G, de Assuncao TM, Mathison AJ, Salmonson A, Kerketta R, Zeighami A, Stodola TJ, Adsay V, Pehlivanoglu B, Dwinell MB, Zimmermann MT, Iovanna JL, Urrutia R, Lomberk G.) Front Cell Dev Biol. 2021;9:681153 PMID: 34249932 PMCID: PMC8261250 SCOPUS ID: 2-s2.0-85116952280 07/13/2021
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(Vonderhaar EP, Barnekow NS, McAllister D, McOlash L, Eid MA, Riese MJ, Tarakanova VL, Johnson BD, Dwinell MB.) Cell Mol Gastroenterol Hepatol. 2021;12(1):41-58 PMID: 33548597 PMCID: PMC8081932 SCOPUS ID: 2-s2.0-85104314508 02/07/2021
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p38γ MAPK Is Essential for Aerobic Glycolysis and Pancreatic Tumorigenesis.
(Wang F, Qi XM, Wertz R, Mortensen M, Hagen C, Evans J, Sheinin Y, James M, Liu P, Tsai S, Thomas J, Mackinnon A, Dwinell M, Myers CR, Bartrons Bach R, Fu L, Chen G.) Cancer Res. 2020 08 15;80(16):3251-3264 PMID: 32580961 SCOPUS ID: 2-s2.0-85089787021 06/26/2020
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Structural Features of an Extended C-Terminal Tail Modulate the Function of the Chemokine CCL21.
(Moussouras NA, Hjortø GM, Peterson FC, Szpakowska M, Chevigné A, Rosenkilde MM, Volkman BF, Dwinell MB.) Biochemistry. 2020 04 07;59(13):1338-1350 PMID: 32182428 PMCID: PMC7307649 SCOPUS ID: 2-s2.0-85083041593 03/18/2020
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(Cheng G, Pan J, Podsiadly R, Zielonka J, Garces AM, Dias Duarte Machado LG, Bennett B, McAllister D, Dwinell MB, You M, Kalyanaraman B.) Free Radic Biol Med. 2020 02 01;147:167-174 PMID: 31874251 PMCID: PMC6948008 SCOPUS ID: 2-s2.0-85076857582 12/25/2019
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(Cheng G, Hardy M, Zielonka J, Weh K, Zielonka M, Boyle KA, Abu Eid M, McAllister D, Bennett B, Kresty LA, Dwinell MB, Kalyanaraman B.) Cancer Treat Res Commun. 2020;25:100210 PMID: 32987287 PMCID: PMC7883397 SCOPUS ID: 2-s2.0-85091576205 09/29/2020
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(Cheng G, Zielonka J, Hardy M, Ouari O, Chitambar CR, Dwinell MB, Kalyanaraman B.) Oncotarget. 2019 May 28;10(37):3518-3532 PMID: 31191823 PMCID: PMC6544408 06/14/2019
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(Jing W, McAllister D, Vonderhaar EP, Palen K, Riese MJ, Gershan J, Johnson BD, Dwinell MB.) J Immunother Cancer. 2019 04 29;7(1):115 PMID: 31036082 PMCID: PMC6489306 SCOPUS ID: 2-s2.0-85065258266 05/01/2019
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(Tsai S, McOlash L, Jia S, Zhang J, Simpson P, Kaldunski ML, Aldakkak M, Grewal J, Palen K, Dwinell MB, Johnson BD, Mackinnon A, Hessner MJ, Gershan JA.) Cancer Epidemiol Biomarkers Prev. 2019 04;28(4):680-689 PMID: 30530849 PMCID: PMC6545232 SCOPUS ID: 2-s2.0-85063867816 12/12/2018
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Mitochondria-targeted drugs stimulate mitophagy and abrogate colon cancer cell proliferation.
(Boyle KA, Van Wickle J, Hill RB, Marchese A, Kalyanaraman B, Dwinell MB.) J Biol Chem. 2018 09 21;293(38):14891-14904 PMID: 30087121 PMCID: PMC6153299 SCOPUS ID: 2-s2.0-85054023214 08/09/2018
Flashback
Lab Alumni
Hong Guan, MS
Doctoral Candidate, Department of Chemistry and Biochemistry, University of South Carolina
Ishan Roy, MD, PhD
Clinical Instructor & Chief Resident Physician; Department of Physical Medicine & Rehabilitation, Northwestern University/Shirley Ryan Ability Lab
Natasha Moussouras, PhD
Research Fellow, Department of Microbiology & Immunology, Medical College of Wisconsin
Emily Vonderhaar, PhD
Clinical Research Training Fellow, Department of Microbiology & Immunology, Medical College of Wisconsin
Jonathan D. Van Wickle
Resident, Radiation Oncology, University of Iowa
Eric A. Luedke, MD
General Surgery, Sharp Memorial Hospital, Stanford Health Care-Stanford Hospital, San Diego, CA.
Yana Thaker, MD
General Internal Medicine, Gastroenterology, University of Washington, Seattle, WA
Joanne P Boisvert (Hayes), MD
Family Medicine Practice, Madras, OR
Egal I. Gorse, MD
2018- Fellowship Hematology and Medical Oncology, Emory University School of Medicine 2020 Recipient Nell W. and William Simpson Elkin Fellowship
Kimberle A Agle. PhD
Scientist-II, Immucor, Inc, Waukesha, WI
Amanda N. Cooper, MD
Private Practice, Dermatology, Germantown, WI
Luke J. Drury, PhD
Human Molecular Geneticist, Prevention Genetics, Marshfield Clinic, Marshfield, WI
Sheena L. Faherty
Science Writer, National Human Genome Research Institute (NHGRI), National Institutes of Health (NIH), Bethesda, MD
Soonyean Hwang, PhD
Postdoctoral Fellow, Dana-Farber Cancer Institute, Harvard Cancer Center, Mentor: Martin E. Hemler, PhD
Priscilla A. Johanesen, PhD
Associate Professor (Tenured), Deputy Head of Department (Education), Department of Microbiology, Monash University, Melbourne, AUSTRALIA
Jennifer M. Boardman (Smith), PhD
Assistant Dean for Academic Affairs for the School of Graduate Studies, Associate Professor, Microbiology and Immunology, Department of Basic Sciences, Geisinger
Rebecca A. Vongsa, PhD
Scientist-III, Kimberly-Clark Corp., Skin Health and Infection Control Health Care Division, Appleton, WI
Michael K. Wendt, PhD
Associate Professor, Purdue University, Lafayette, IN
Noah P. Zimmerman, PhD
Research Manager, Arm and Hammer, Waukesha, WI