Research Bench Lab

Dwinell Laboratory

Location

Microbiology & Immunology

TBRC C3860

General Interests

Cancer Metastasis, Tumor Microenvironment, Mucosal Inflammation

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Michael Dwinell Laboratory
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Research Areas

Research in the Dwinell laboratory seeks to define the role for extracellular mediators in the progression and metastasis of solid and hematological cancers. Additional studies are examining the role for metabolic reprogramming to influence tumor progression and exploring new mitochondria-targeted compounds as inhibitors of cancer progression. Human and murine 2D and 3D cell culture systems and preclinical models are being used to investigate the cellular, biochemical, and metabolic signaling pathways that regulate cellular proliferation, programmed cell death and motility in inflammation and cancer. Pharmacokinetic / pharmacodynamics, toxicity and potency / efficacy studies following treatment with small molecule or biologic compounds are also being completed. These translational research studies are multidisciplinary and include molecular cloning, cell culture, biochemical assays and signal processing, histopathology, flow cytometry, and small animal imaging and handling. Completion of these studies will strengthen our identification of new targets for therapeutic intervention to improve human health.

Research Support

Research in the Dwinell laboratory is supported through grants from the National Institutes of Health, the Medical College of Wisconsin Cancer Center and philanthropic donations.

Current Members

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Donna McAllister

Lab Supervisor

dmcallis@mcw.edu

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Kathleen Boyle, PhD

Adjunct Assistant Professor

kboyle@mcw.edu

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Nicholas Barnekow

Research Technologist II

nbarnekow@mcw.edu

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Laura McOlash

Research Technologist III

lmcolash@mcw.edu

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Mahmoud Abu Eid

Graduate Student

mabueid@mcw.edu

Recent Publications

Lab Alumni

Kim Agle, PhD
Research Scientist, Department of Medicine, Medical College of Wisconsin

Amanda Cooper, MD
Dermatology Residency, University of Illinois Chicago College of Medicine, Chicago

Luke Drury, PhD
Human Molecular Geneticist, Prevention Genetics

Sheena Faherty
Predoctoral student, Duke University, Durham, NC

Soonyean Hwang, PhD
Postdoctoral Fellow, Boston University

Priscilla Johanesen, PhD
Instructor at Monash University, Australia

Jennifer Smith, PhD
Assistant Professor and Director Office of Research Compliance at The Commonwealth Medical College

Rebecca Vongsa, PhD
Scientist III at Kimberly Clark Corporation

Michael Wendt, PhD
Assistant Professor Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University

Noah Zimmerman, PhD
Vice President of Research and Development at Agro BioSciences, Inc, Milwaukee, WI