Scott S. Terhune, PhD

Professor

Locations

Microbiology & Immunology
TBRC C2890

Contact Information

General Interests

Human Cytomegalovirus Host-Cell Protein Interactions During Infection

Education

PhD, Cancer Biology, Northwestern University, 2000
Postdoctoral Fellow, Proteomics/Cytomegalovirus Biology, Princeton University, 2007

Learn more about the Terhune Lab

Research Interests

Our research focuses on determining the molecular functions of human cytomegalovirus (HCMV) proteins during infection and disease. HCMV is a member of the beta-herpesvirus family of viruses which includes HHV-6 and 7. Infection occurs upon exposure to virus-containing body fluids, is life-long and generally asymptomatic in healthy children and adults. However, during pregnancy, HCMV infection may result in congenital birth defects including hearing loss and neurological damage. In immunologically immature or compromised children and adults, infection often results in life threatening diseases. And, increasing evidence suggestions that persistent life-long HCMV infection is associated with numerous chronic diseases including atherosclerosis, immuno-senescence, cancer and possibly Alzheimer’s Disease.

Human cytomegalovirus induces significant structural and functional changes in terminally differentiated human cortical neurons.

(Adelman JW, Rosas-Rogers S, Schumacher ML, Mokry RL, Terhune SS, Ebert AD.) mBio. 2023 Nov 15:e0225123 PMID: 37966250 11/15/2023
Neutralizing antibodies with neurotropic factor treatment maintain neurodevelopmental gene expression upon exposure to human cytomegalovirus.

(O'Brien BS, Mokry RL, Schumacher ML, Rosas-Rogers S, Terhune SS, Ebert AD.) J Virol. 2023 Oct 05;97(10):e0069623 PMID: 37796129 PMCID: PMC10653813 SCOPUS ID: 2-s2.0-85175819477 10/05/2023
Human cytomegalovirus UL138 interaction with USP1 activates STAT1 in infection.

(Zarrella K, Longmire P, Zeltzer S, Collins-McMillen D, Hancock M, Buehler J, Reitsma JM, Terhune SS, Nelson JA, Goodrum F.) PLoS Pathog. 2023 Jun;19(6):e1011185 PMID: 37289831 PMCID: PMC10284425 SCOPUS ID: 2-s2.0-85163920856 06/08/2023
Human Cytomegalovirus Induces Significant Structural and Functional Changes in Terminally Differentiated Human Cortical Neurons.

(Adelman JW, Rosas-Rogers S, Schumacher ML, Mokry RL, Terhune SS, Ebert AD.) bioRxiv. 2023 Mar 06 PMID: 36945635 PMCID: PMC10028818 03/23/2023
Critical Role for the Human Cytomegalovirus Major Immediate Early Proteins in Recruitment of RNA Polymerase II and H3K27Ac To an Enhancer-Like Element in OriLyt.

(Forte E, Li M, Ayaloglu Butun F, Hu Q, Borst EM, Schipma MJ, Piunti A, Shilatifard A, Terhune SS, Abecassis M, Meier JL, Hummel M.) Microbiol Spectr. 2023 Feb 14;11(1):e0314422 PMID: 36645269 PMCID: PMC9927211 SCOPUS ID: 2-s2.0-85148092420 01/17/2023
Simulating the Evolution of Signaling Signatures during CART-Cell - Tumor Cell Interactions.

(Shah V, Womack J, Zamora AE, Terhune SS, Dash RK.) ArXiv. 2023 Feb 08 PMID: 36798455 PMCID: PMC9934731 02/18/2023
Human Cytomegalovirus UL138 Interaction with USP1 Activates STAT1 in infection.

(Zarrella K, Longmire P, Zeltzer S, Collins-McMillen D, Hancock M, Buehler J, Reitsma JM, Terhune SS, Nelson JA, Goodrum F.) bioRxiv. 2023 Feb 07 PMID: 36798153 PMCID: PMC9934528 02/18/2023
Computational modeling of protracted HCMV replication using genome substrates and protein temporal profiles.

(Monti CE, Mokry RL, Schumacher ML, Dash RK, Terhune SS.) Proc Natl Acad Sci U S A. 2022 Aug 30;119(35):e2201787119 PMID: 35994667 PMCID: PMC9437303 SCOPUS ID: 2-s2.0-85136192098 08/23/2022
Nitric Oxide Attenuates Human Cytomegalovirus Infection yet Disrupts Neural Cell Differentiation and Tissue Organization.

(Mokry RL, O'Brien BS, Adelman JW, Rosas S, Schumacher ML, Ebert AD, Terhune SS.) J Virol. 2022 Jul 27;96(14):e0012622 PMID: 35862705 PMCID: PMC9327702 SCOPUS ID: 2-s2.0-85135227929 07/22/2022
Downregulation of neurodevelopmental gene expression in iPSC-derived cerebral organoids upon infection by human cytomegalovirus.

(O'Brien BS, Mokry RL, Schumacher ML, Pulakanti K, Rao S, Terhune SS, Ebert AD.) iScience. 2022 Apr 15;25(4):104098 PMID: 35391828 PMCID: PMC8980761 04/09/2022
Human cytomegalovirus lytic infection inhibits replication-dependent histone synthesis and requires stem loop binding protein function.

(Albright ER, Morrison K, Ranganathan P, Carter DM, Nishikiori M, Lee JH, Slayton MD, Ahlquist P, Terhune SS, Kalejta RF.) Proc Natl Acad Sci U S A. 2022 Apr 05;119(14):e2122174119 PMID: 35344424 PMCID: PMC9169081 SCOPUS ID: 2-s2.0-85127264685 03/29/2022
Method to Study Adaptive NK Cells Following MCMV Infections.

(Khalil M, Mei A, Hashemi E, Wang D, Schumacher M, Terhune S, Malarkannan S.) Methods Mol Biol. 2022;2463:195-204 PMID: 35344176 SCOPUS ID: 2-s2.0-85127680170 03/29/2022