Scott S. Terhune, PhD

Professor

Locations

Microbiology & Immunology
TBRC C2890

Contact Information

General Interests

Human Cytomegalovirus Host-Cell Protein Interactions During Infection

Education

PhD, Cancer Biology, Northwestern University, 2000
Postdoctoral Fellow, Proteomics/Cytomegalovirus Biology, Princeton University, 2007

Learn more about the Terhune Lab

                
                    Research Experience
                

                    Antiviral Agents
Cell Cycle
Cyclin-Dependent Kinase Inhibitor p21
Cytomegalovirus
Histone Acetyltransferases
Histone Deacetylases
Host-Pathogen Interactions
Protein Kinases
Signal Transduction
STAT3 Transcription Factor
Tumor Suppressor Protein p53

            

                
                    Methodologies and Techniques
                

                    Cell Cycle
DNA, Viral
Drug Synergism
Protein Interaction Mapping
Proteomics
RNA, Viral
Virus Replication

            

                
                    Leadership Positions
                

                    Dept Representative, Faculty Council
Past Chair, Faculty Career Development Committee
Program Representative, IDP Executive Evaluation Committee
SOM and Graduate School Rank Committees
Vice Chair, Institutional Biosafety Committee

            

Research Interests

Our research focuses on determining the molecular functions of human cytomegalovirus (HCMV) proteins during infection and disease. HCMV is a member of the beta-herpesvirus family of viruses which includes HHV-6 and 7. Infection occurs upon exposure to virus-containing body fluids, is life-long and generally asymptomatic in healthy children and adults. However, during pregnancy, HCMV infection may result in congenital birth defects including hearing loss and neurological damage. In immunologically immature or compromised children and adults, infection often results in life threatening diseases. And, increasing evidence suggestions that persistent life-long HCMV infection is associated with numerous chronic diseases including atherosclerosis, immuno-senescence, cancer and possibly Alzheimer’s Disease.

Human cytomegalovirus lytic infection inhibits replication-dependent histone synthesis and requires stem loop binding protein function.

(Albright ER, Morrison K, Ranganathan P, Carter DM, Nishikiori M, Lee JH, Slayton MD, Ahlquist P, Terhune SS, Kalejta RF.) Proc Natl Acad Sci U S A. 2022 04 05;119(14):e2122174119 PMID: 35344424 SCOPUS ID: 2-s2.0-85127264685 03/29/2022
Downregulation of neurodevelopmental gene expression in iPSC-derived cerebral organoids upon infection by human cytomegalovirus

(O'Brien BS, Mokry RL, Schumacher ML, Pulakanti K, Rao S, Terhune SS, Ebert AD.) iScience. 15 April 2022;25(4) SCOPUS ID: 2-s2.0-85127531399 04/15/2022
Method to Study Adaptive NK Cells Following MCMV Infections.

(Khalil M, Mei A, Hashemi E, Wang D, Schumacher M, Terhune S, Malarkannan S.) Methods Mol Biol. 2022;2463:195-204 PMID: 35344176 SCOPUS ID: 2-s2.0-85127680170 03/29/2022
Crosstalk between Plk1, p53, cell cycle, and G2/M DNA damage checkpoint regulation in cancer: computational modeling and analysis.

(Jung Y, Kraikivski P, Shafiekhani S, Terhune SS, Dash RK.) NPJ Syst Biol Appl. 2021 12 09;7(1):46 PMID: 34887439 PMCID: PMC8660825 SCOPUS ID: 2-s2.0-85121043614 12/11/2021
MyD88 is an essential regulator of NK cell-mediated clearance of MCMV infection.

(Dixon KJ, Siebert JR, Wang D, Abel AM, Johnson KE, Riese MJ, Terhune SS, Tarakanova VL, Thakar MS, Malarkannan S.) Mol Immunol. 2021 09;137:94-104 PMID: 34242922 SCOPUS ID: 2-s2.0-85109126048 07/10/2021
Implications of a 'Third Signal' in NK Cells.

(Khalil M, Wang D, Hashemi E, Terhune SS, Malarkannan S.) Cells. 2021 07 31;10(8) PMID: 34440725 PMCID: PMC8393955 SCOPUS ID: 2-s2.0-85115044374 08/28/2021
Nitric Oxide Circumvents Virus-Mediated Metabolic Regulation during Human Cytomegalovirus Infection.

(Mokry RL, Schumacher ML, Hogg N, Terhune SS.) mBio. 2020 12 15;11(6) PMID: 33323506 PMCID: PMC7773989 SCOPUS ID: 2-s2.0-85098068781 12/17/2020
Prospects for Clinical Development of Stat5 Inhibitor IST5-002: High Transcriptomic Specificity in Prostate Cancer and Low Toxicity In Vivo.

(Maranto C, Udhane V, Jia J, Verma R, Müller-Newen G, LaViolette PS, Pereckas M, Sabharwal L, Terhune S, Pattabiraman N, Njar VCO, Imig JD, Wang L, Nevalainen MT.) Cancers (Basel). 2020 Nov 18;12(11) PMID: 33217941 PMCID: PMC7724566 SCOPUS ID: 2-s2.0-85096199725 11/22/2020
Network mechanisms and dysfunction within an integrated computational model of progression through mitosis in the human cell cycle.

(Terhune SS, Jung Y, Cataldo KM, Dash RK.) PLoS Comput Biol. 2020 04;16(4):e1007733 PMID: 32251461 PMCID: PMC7162553 SCOPUS ID: 2-s2.0-85083620688 04/07/2020
Erratum for Rak et al., Human Cytomegalovirus UL135 Interacts with Host Adaptor Proteins To Regulate Epidermal Growth Factor Receptor and Reactivation from Latency.

(Rak MA, Buehler J, Zeltzer S, Reitsma J, Molina B, Terhune S, Goodrum F.) J Virol. 2020 03 17;94(7) PMID: 32184335 PMCID: PMC7081901 SCOPUS ID: 2-s2.0-85082001595 03/19/2020
Nitric oxide circumvents virus-mediated metabolic regulation during human cytomegalovirus infection

(Mokry RL, Schumacher ML, Hogg N, Terhune SS.) mBio. November-December 2020;11(6):1-25 SCOPUS ID: 2-s2.0-85098068781 11/01/2020
Human Cytomegalovirus Disruption of Calcium Signaling in Neural Progenitor Cells and Organoids.

(Sison SL, O'Brien BS, Johnson AJ, Seminary ER, Terhune SS, Ebert AD.) J Virol. 2019 09 01;93(17) PMID: 31217241 PMCID: PMC6694809 SCOPUS ID: 2-s2.0-85071355135 06/21/2019

Microbiology & Immunology