
Scott S. Terhune, PhD
Professor
Locations
- Microbiology & Immunology
TBRC C2890
Contact Information
General Interests
Education
Postdoctoral Fellow, Proteomics/Cytomegalovirus Biology, Princeton University, 2007
Research Experience
- Antiviral Agents
- Cell Cycle
- Cyclin-Dependent Kinase Inhibitor p21
- Cytomegalovirus
- Histone Acetyltransferases
- Histone Deacetylases
- Host-Pathogen Interactions
- Protein Kinases
- Signal Transduction
- STAT3 Transcription Factor
- Tumor Suppressor Protein p53
Methodologies and Techniques
- Cell Cycle
- DNA, Viral
- Drug Synergism
- Protein Interaction Mapping
- Proteomics
- RNA, Viral
- Virus Replication
Leadership Positions
- Dept Representative, Faculty Council
- Past Chair, Faculty Career Development Committee
- Program Representative, IDP Executive Evaluation Committee
- SOM and Graduate School Rank Committees
- Vice Chair, Institutional Biosafety Committee
Research Interests
Our research focuses on determining the molecular functions of human cytomegalovirus (HCMV) proteins during infection and disease. HCMV is a member of the beta-herpesvirus family of viruses which includes HHV-6 and 7. Infection occurs upon exposure to virus-containing body fluids, is life-long and generally asymptomatic in healthy children and adults. However, during pregnancy, HCMV infection may result in congenital birth defects including hearing loss and neurological damage. In immunologically immature or compromised children and adults, infection often results in life threatening diseases. And, increasing evidence suggestions that persistent life-long HCMV infection is associated with numerous chronic diseases including atherosclerosis, immuno-senescence, cancer and possibly Alzheimer’s Disease.
Publications
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(Albright ER, Morrison K, Ranganathan P, Carter DM, Nishikiori M, Lee JH, Slayton MD, Ahlquist P, Terhune SS, Kalejta RF.) Proc Natl Acad Sci U S A. 2022 04 05;119(14):e2122174119 PMID: 35344424 SCOPUS ID: 2-s2.0-85127264685 03/29/2022
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(O'Brien BS, Mokry RL, Schumacher ML, Pulakanti K, Rao S, Terhune SS, Ebert AD.) iScience. 15 April 2022;25(4) SCOPUS ID: 2-s2.0-85127531399 04/15/2022
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Method to Study Adaptive NK Cells Following MCMV Infections.
(Khalil M, Mei A, Hashemi E, Wang D, Schumacher M, Terhune S, Malarkannan S.) Methods Mol Biol. 2022;2463:195-204 PMID: 35344176 SCOPUS ID: 2-s2.0-85127680170 03/29/2022
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(Jung Y, Kraikivski P, Shafiekhani S, Terhune SS, Dash RK.) NPJ Syst Biol Appl. 2021 12 09;7(1):46 PMID: 34887439 PMCID: PMC8660825 SCOPUS ID: 2-s2.0-85121043614 12/11/2021
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MyD88 is an essential regulator of NK cell-mediated clearance of MCMV infection.
(Dixon KJ, Siebert JR, Wang D, Abel AM, Johnson KE, Riese MJ, Terhune SS, Tarakanova VL, Thakar MS, Malarkannan S.) Mol Immunol. 2021 09;137:94-104 PMID: 34242922 SCOPUS ID: 2-s2.0-85109126048 07/10/2021
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Implications of a 'Third Signal' in NK Cells.
(Khalil M, Wang D, Hashemi E, Terhune SS, Malarkannan S.) Cells. 2021 07 31;10(8) PMID: 34440725 PMCID: PMC8393955 SCOPUS ID: 2-s2.0-85115044374 08/28/2021
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Nitric Oxide Circumvents Virus-Mediated Metabolic Regulation during Human Cytomegalovirus Infection.
(Mokry RL, Schumacher ML, Hogg N, Terhune SS.) mBio. 2020 12 15;11(6) PMID: 33323506 PMCID: PMC7773989 SCOPUS ID: 2-s2.0-85098068781 12/17/2020
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(Maranto C, Udhane V, Jia J, Verma R, Müller-Newen G, LaViolette PS, Pereckas M, Sabharwal L, Terhune S, Pattabiraman N, Njar VCO, Imig JD, Wang L, Nevalainen MT.) Cancers (Basel). 2020 Nov 18;12(11) PMID: 33217941 PMCID: PMC7724566 SCOPUS ID: 2-s2.0-85096199725 11/22/2020
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(Terhune SS, Jung Y, Cataldo KM, Dash RK.) PLoS Comput Biol. 2020 04;16(4):e1007733 PMID: 32251461 PMCID: PMC7162553 SCOPUS ID: 2-s2.0-85083620688 04/07/2020
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(Rak MA, Buehler J, Zeltzer S, Reitsma J, Molina B, Terhune S, Goodrum F.) J Virol. 2020 03 17;94(7) PMID: 32184335 PMCID: PMC7081901 SCOPUS ID: 2-s2.0-85082001595 03/19/2020
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Nitric oxide circumvents virus-mediated metabolic regulation during human cytomegalovirus infection
(Mokry RL, Schumacher ML, Hogg N, Terhune SS.) mBio. November-December 2020;11(6):1-25 SCOPUS ID: 2-s2.0-85098068781 11/01/2020
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Human Cytomegalovirus Disruption of Calcium Signaling in Neural Progenitor Cells and Organoids.
(Sison SL, O'Brien BS, Johnson AJ, Seminary ER, Terhune SS, Ebert AD.) J Virol. 2019 09 01;93(17) PMID: 31217241 PMCID: PMC6694809 SCOPUS ID: 2-s2.0-85071355135 06/21/2019