
Scott S. Terhune, PhD
Professor
Locations
- Microbiology & Immunology
TBRC C2890
Contact Information
General Interests
Education
Postdoctoral Fellow, Proteomics/Cytomegalovirus Biology, Princeton University, 2007
Research Experience
- Antiviral Agents
- Cell Cycle
- Cyclin-Dependent Kinase Inhibitor p21
- Cytomegalovirus
- Histone Acetyltransferases
- Histone Deacetylases
- Host-Pathogen Interactions
- Protein Kinases
- Signal Transduction
- STAT3 Transcription Factor
- Tumor Suppressor Protein p53
Methodologies and Techniques
- Cell Cycle
- DNA, Viral
- Drug Synergism
- Protein Interaction Mapping
- Proteomics
- RNA, Viral
- Virus Replication
Leadership Positions
- Dept Representative, Faculty Council
- Past Chair, Faculty Career Development Committee
- Program Representative, IDP Executive Evaluation Committee
- Vice Chair, Institutional Biosafety Committee
Research Interests
Our research focuses on determining the molecular functions of human cytomegalovirus (HCMV) proteins during infection and disease. HCMV is a member of the beta-herpesvirus family of viruses which includes HHV-6 and 7. Infection occurs upon exposure to virus-containing body fluids, is life-long and generally asymptomatic in healthy children and adults. However, during pregnancy, HCMV infection may result in congenital birth defects including hearing loss and neurological damage. In immunologically immature or compromised children and adults, infection often results in life threatening diseases. And, increasing evidence suggestions that persistent life-long HCMV infection is associated with numerous chronic diseases including atherosclerosis, immuno-senescence, cancer and possibly Alzheimer’s Disease.
Publications
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(Maranto C, Udhane V, Jia J, Verma R, Müller-Newen G, LaViolette PS, Pereckas M, Sabharwal L, Terhune S, Pattabiraman N, Njar VCO, Imig JD, Wang L, Nevalainen MT.) Cancers (Basel). 2020 Nov 18;12(11) PMID: 33217941 PMCID: PMC7724566 SCOPUS ID: 2-s2.0-85096199725 11/22/2020
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(Terhune SS, Jung Y, Cataldo KM, Dash RK.) PLoS Comput Biol. 2020 04;16(4):e1007733 PMID: 32251461 PMCID: PMC7162553 SCOPUS ID: 2-s2.0-85083620688 04/07/2020
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(Rak MA, Buehler J, Zeltzer S, Reitsma J, Molina B, Terhune S, Goodrum F.) J Virol. 2020 03 17;94(7) PMID: 32184335 PMCID: PMC7081901 SCOPUS ID: 2-s2.0-85082001595 03/19/2020
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Nitric oxide circumvents virus-mediated metabolic regulation during human cytomegalovirus infection
(Mokry RL, Schumacher ML, Hogg N, Terhune SS.) mBio. November-December 2020;11(6):1-25 SCOPUS ID: 2-s2.0-85098068781 11/01/2020
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Human Cytomegalovirus Disruption of Calcium Signaling in Neural Progenitor Cells and Organoids.
(Sison SL, O'Brien BS, Johnson AJ, Seminary ER, Terhune SS, Ebert AD.) J Virol. 2019 09 01;93(17) PMID: 31217241 PMCID: PMC6694809 SCOPUS ID: 2-s2.0-85071355135 06/21/2019
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(Rak MA, Buehler J, Zeltzer S, Reitsma J, Molina B, Terhune S, Goodrum F.) J Virol. 2018 10 15;92(20) PMID: 30089695 PMCID: PMC6158428 SCOPUS ID: 2-s2.0-85052151483 08/10/2018
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(Forte E, Swaminathan S, Schroeder MW, Kim JY, Terhune SS, Hummel M.) mBio. 2018 09 11;9(5) PMID: 30206173 PMCID: PMC6134100 SCOPUS ID: 2-s2.0-85055538738 09/13/2018
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Isomer-specific effect of microRNA miR-29b on nuclear morphology.
(Kriegel AJ, Terhune SS, Greene AS, Noon KR, Pereckas MS, Liang M.) J Biol Chem. 2018 09 07;293(36):14080-14088 PMID: 30006350 PMCID: PMC6130969 SCOPUS ID: 2-s2.0-85053013199 07/15/2018
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Association of Mycobacterium Proteins with Lipid Droplets.
(Armstrong RM, Carter DC, Atkinson SN, Terhune SS, Zahrt TC.) J Bacteriol. 2018 08 15;200(16) PMID: 29760207 PMCID: PMC6060360 SCOPUS ID: 2-s2.0-85050494395 05/16/2018
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(Westdorp KN, Terhune SS.) Antiviral Res. 2018 05;153:33-38 PMID: 29458130 PMCID: PMC6015744 SCOPUS ID: 2-s2.0-85043578832 02/20/2018
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(Mounce BC, Mboko WP, Bigley TM, Terhune SS, Tarakanova VL.) J Virol. 2018 01 01;92(1) PMID: 29242252 PMCID: PMC5730793 SCOPUS ID: 2-s2.0-85037989790 12/16/2017
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(Gonyo P, Bergom C, Brandt AC, Tsaih SW, Sun Y, Bigley TM, Lorimer EL, Terhune SS, Rui H, Flister MJ, Long RM, Williams CL.) Oncogene. 2017 12 14;36(50):6873-6883 PMID: 28806394 PMCID: PMC5730474 SCOPUS ID: 2-s2.0-85038242723 08/15/2017