Scott S. Terhune, PhD

Professor

Locations

Microbiology & Immunology
TBRC C2890

Contact Information

General Interests

Human Cytomegalovirus Host-Cell Protein Interactions During Infection

Education

PhD, Cancer Biology, Northwestern University, 2000
Postdoctoral Fellow, Proteomics/Cytomegalovirus Biology, Princeton University, 2007

Learn more about the Terhune Lab

                
                    Research Experience
                

                    Antiviral Agents
Cell Cycle
Cyclin-Dependent Kinase Inhibitor p21
Cytomegalovirus
Histone Acetyltransferases
Histone Deacetylases
Host-Pathogen Interactions
Protein Kinases
Signal Transduction
STAT3 Transcription Factor
Tumor Suppressor Protein p53

            

                
                    Methodologies and Techniques
                

                    Cell Cycle
DNA, Viral
Drug Synergism
Protein Interaction Mapping
Proteomics
RNA, Viral
Virus Replication

            

                
                    Leadership Positions
                

                    Dept Representative, Faculty Council
Past Chair, Faculty Career Development Committee
Program Representative, IDP Executive Evaluation Committee
Vice Chair, Institutional Biosafety Committee

            

Research Interests

Our research focuses on determining the molecular functions of human cytomegalovirus (HCMV) proteins during infection and disease. HCMV is a member of the beta-herpesvirus family of viruses which includes HHV-6 and 7. Infection occurs upon exposure to virus-containing body fluids, is life-long and generally asymptomatic in healthy children and adults. However, during pregnancy, HCMV infection may result in congenital birth defects including hearing loss and neurological damage. In immunologically immature or compromised children and adults, infection often results in life threatening diseases. And, increasing evidence suggestions that persistent life-long HCMV infection is associated with numerous chronic diseases including atherosclerosis, immuno-senescence, cancer and possibly Alzheimer’s Disease.

MyD88 is an essential regulator of NK cell-mediated clearance of MCMV infection.

(Dixon KJ, Siebert JR, Wang D, Abel AM, Johnson KE, Riese MJ, Terhune SS, Tarakanova VL, Thakar MS, Malarkannan S.) Mol Immunol. 2021 09;137:94-104 PMID: 34242922 SCOPUS ID: 2-s2.0-85109126048 07/10/2021
Implications of a 'Third Signal' in NK Cells.

(Khalil M, Wang D, Hashemi E, Terhune SS, Malarkannan S.) Cells. 2021 Jul 31;10(8) PMID: 34440725 PMCID: PMC8393955 08/28/2021
Nitric Oxide Circumvents Virus-Mediated Metabolic Regulation during Human Cytomegalovirus Infection.

(Mokry RL, Schumacher ML, Hogg N, Terhune SS.) mBio. 2020 12 15;11(6) PMID: 33323506 PMCID: PMC7773989 SCOPUS ID: 2-s2.0-85098068781 12/17/2020
Prospects for Clinical Development of Stat5 Inhibitor IST5-002: High Transcriptomic Specificity in Prostate Cancer and Low Toxicity In Vivo.

(Maranto C, Udhane V, Jia J, Verma R, Müller-Newen G, LaViolette PS, Pereckas M, Sabharwal L, Terhune S, Pattabiraman N, Njar VCO, Imig JD, Wang L, Nevalainen MT.) Cancers (Basel). 2020 Nov 18;12(11) PMID: 33217941 PMCID: PMC7724566 SCOPUS ID: 2-s2.0-85096199725 11/22/2020
Network mechanisms and dysfunction within an integrated computational model of progression through mitosis in the human cell cycle.

(Terhune SS, Jung Y, Cataldo KM, Dash RK.) PLoS Comput Biol. 2020 04;16(4):e1007733 PMID: 32251461 PMCID: PMC7162553 SCOPUS ID: 2-s2.0-85083620688 04/07/2020
Erratum for Rak et al., Human Cytomegalovirus UL135 Interacts with Host Adaptor Proteins To Regulate Epidermal Growth Factor Receptor and Reactivation from Latency.

(Rak MA, Buehler J, Zeltzer S, Reitsma J, Molina B, Terhune S, Goodrum F.) J Virol. 2020 03 17;94(7) PMID: 32184335 PMCID: PMC7081901 SCOPUS ID: 2-s2.0-85082001595 03/19/2020
Nitric oxide circumvents virus-mediated metabolic regulation during human cytomegalovirus infection

(Mokry RL, Schumacher ML, Hogg N, Terhune SS.) mBio. November-December 2020;11(6):1-25 SCOPUS ID: 2-s2.0-85098068781 11/01/2020
Human Cytomegalovirus Disruption of Calcium Signaling in Neural Progenitor Cells and Organoids.

(Sison SL, O'Brien BS, Johnson AJ, Seminary ER, Terhune SS, Ebert AD.) J Virol. 2019 09 01;93(17) PMID: 31217241 PMCID: PMC6694809 SCOPUS ID: 2-s2.0-85071355135 06/21/2019
Human Cytomegalovirus UL135 Interacts with Host Adaptor Proteins To Regulate Epidermal Growth Factor Receptor and Reactivation from Latency.

(Rak MA, Buehler J, Zeltzer S, Reitsma J, Molina B, Terhune S, Goodrum F.) J Virol. 2018 10 15;92(20) PMID: 30089695 PMCID: PMC6158428 SCOPUS ID: 2-s2.0-85052151483 08/10/2018
Tumor Necrosis Factor Alpha Induces Reactivation of Human Cytomegalovirus Independently of Myeloid Cell Differentiation following Posttranscriptional Establishment of Latency.

(Forte E, Swaminathan S, Schroeder MW, Kim JY, Terhune SS, Hummel M.) mBio. 2018 09 11;9(5) PMID: 30206173 PMCID: PMC6134100 SCOPUS ID: 2-s2.0-85055538738 09/13/2018
Isomer-specific effect of microRNA miR-29b on nuclear morphology.

(Kriegel AJ, Terhune SS, Greene AS, Noon KR, Pereckas MS, Liang M.) J Biol Chem. 2018 09 07;293(36):14080-14088 PMID: 30006350 PMCID: PMC6130969 SCOPUS ID: 2-s2.0-85053013199 07/15/2018
Association of Mycobacterium Proteins with Lipid Droplets.

(Armstrong RM, Carter DC, Atkinson SN, Terhune SS, Zahrt TC.) J Bacteriol. 2018 08 15;200(16) PMID: 29760207 PMCID: PMC6060360 SCOPUS ID: 2-s2.0-85050494395 05/16/2018

Microbiology & Immunology