Diane S. Book, MD
Professor
Locations
- Froedtert Hospital
- Neuroscience Center – Specialty Clinics
Specialties
- Behavioral Neurology
- Neurology
Languages
- English
Neurology-Appointment by Referral Only
Education
- MD - Doctor of Medicine
Biography
Appointments
Medical Director, Froedtert & the Medical College of Wisconsin Stroke Program
Specialty
Adult Neurology
Subspecialties
Stroke and Cerebrovascular Disease, stroke clinic quality, acute stroke therapy, small vessel diseases
CADASIL
Dementia
Training
Resident, Neurology, Medical College of Wisconsin Affiliated Hospitals, Milwaukee, WI, 1991-1995.
Fellow, Behavioral Neurology Fellowship, Stroke/Dementia, Medical College of Wisconsin, Milwaukee, WI, 1995-1996.
Societies
American Medical Association
American Heart Association Stroke Council
American Academy of Neurology | Wisconsin Stroke Committee
View Faculty Collaboration Database profile
Honors and Awards
American Medical Women's Association Scholastic Achievement Award
Phi Beta Kappa
Phi Kappa Phi
Best Doctor 2017-2018
Top Doctors
Froedtert & the Medical College Stroke & Neurovascular Program - receives Joint Commission Primary Stroke Center Certification 2006-present, and American Heart Association Performance Achievement Awards for clinical care quality
Research Interests
Ischemic Stroke Evaluation and Management, Hyperacute Stroke, Stroke Education, Stroke Care Quality, Dementias
Current and Previous Research Projects
Secondary Prevention of Small Subcortical Strokes (SPS3); NIH/NINDS , local Principal Investigator
Publications
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Histamine is a molecular transducer of adaptation to endurance exercise training in humans.
(Sieck DC, Kobak SH, Larson EA, Dreyer HC, Fogarty MJ, Sieck GC, Minson CT, Halliwill JR.) J Appl Physiol (1985). 2025 Jun 01;138(6):1398-1410 PMID: 40372922 PMCID: PMC12175747 05/15/2025
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Lesion correlates of impaired acoustic-phonetic perception after unilateral left hemisphere stroke.
(Binder JR, Freiberg A, Heffernan J, Giraldo-Chica M, Book DS, Pillay SB.) Brain. 2025 Apr 03;148(4):1421-1434 PMID: 39789712 PMCID: PMC12168130 SCOPUS ID: 2-s2.0-105003923504 01/10/2025
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(Lisa Baumann Kreuziger, Hatim Attar, Diane Book, Ashley Cunningham, Alexandra Harrington, Jacob Janssen, Julie Kolinski, Benjamin Jung, Nathan Ledeboer, Jennifer McIntosh, Siddhartha Singh .) the 33rd Congress of the International Society on Thrombosis and Haemostasis to be held in Washington, D.C., U.S. from June 21 – 25, 2025. . 06/21/2025
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Semantic network activation facilitates oral word reading in chronic aphasia.
(Pillay SB, Gross WL, Heffernan J, Book DS, Binder JR.) Brain Lang. 2022 Oct;233:105164 PMID: 35933744 PMCID: PMC9948519 SCOPUS ID: 2-s2.0-85135407900 08/08/2022
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The Neural Basis of Successful Word Reading in Aphasia.
(Pillay SB, Gross WL, Graves WW, Humphries C, Book DS, Binder JR.) J Cogn Neurosci. 2018 Apr;30(4):514-525 PMID: 29211656 PMCID: PMC9926535 SCOPUS ID: 2-s2.0-85042764522 12/07/2017
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Lesion localization of speech comprehension deficits in chronic aphasia.
(Pillay SB, Binder JR, Humphries C, Gross WL, Book DS.) Neurology. 2017 Mar 07;88(10):970-975 PMID: 28179469 PMCID: PMC5333516 SCOPUS ID: 2-s2.0-85014816931 02/10/2017
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(Binder JR, Pillay SB, Humphries CJ, Gross WL, Graves WW, Book DS.) Brain. 2016 May;139(Pt 5):1517-26 PMID: 26966139 PMCID: PMC5006249 SCOPUS ID: 2-s2.0-84966648862 03/12/2016
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Cerebral localization of impaired phonological retrieval during rhyme judgment.
(Pillay SB, Stengel BC, Humphries C, Book DS, Binder JR.) Ann Neurol. 2014 Nov;76(5):738-46 PMID: 25164766 PMCID: PMC4214892 SCOPUS ID: 2-s2.0-84912085803 08/29/2014
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Closure of patent foramen ovale versus medical therapy after cryptogenic stroke.
(Carroll JD, Saver JL, Thaler DE, Smalling RW, Berry S, MacDonald LA, Marks DS, Tirschwell DL, RESPECT Investigators.) N Engl J Med. 2013 Mar 21;368(12):1092-100 PMID: 23514286 03/22/2013
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Effects of clopidogrel added to aspirin in patients with recent lacunar stroke.
(SPS3 Investigators, Benavente OR, Hart RG, McClure LA, Szychowski JM, Coffey CS, Pearce LA.) N Engl J Med. 2012 Aug 30;367(9):817-25 PMID: 22931315 PMCID: PMC4067036 08/31/2012
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High-dose atorvastatin after stroke or transient ischemic attack.
(Amarenco P, Bogousslavsky J, Callahan A 3rd, Goldstein LB, Hennerici M, Rudolph AE, Sillesen H, Simunovic L, Szarek M, Welch KM, Zivin JA, Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) Investigators.) N Engl J Med. 2006 Aug 10;355(6):549-59 PMID: 16899775 08/11/2006
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Clipping the Eagle's wings: treatment of an unusual cause of transient cerebral ischemia.
(Varelas PN, Sinson G, Rand S, Book D.) Neurology. 2005 Jan 25;64(2):393-4 PMID: 15668456 SCOPUS ID: 2-s2.0-12544250987 01/26/2005