Gopika SenthilKumar

Cardiovascular physiology, health education, surgical outcomes and quality improvement

Research Experience

Medical College of Wisconsin, 2021-present
PhD Advisors: Julie Freed, MD, PhD and David Gutterman, MD
Project: Estrogen regulation of spingosine-1-phosphate signaling in the human microcirculation

University of Wisconsin, Madison, 2017-2019
Advisors: Randall Kimple MD PhD
Projects: Inhibition of fibroblast growth factor receptor using AZD4547 radiosensitizes Head and Neck Cancer and Lung Cancer. Autophagy's role in Head and Neck Cancer’s therapeutic resistance to radiation and cetuximab.

University of Wisconsin, Madison, 2015-2016
Advisors: Gillian McLellan BVMS PhD
Project: 3D reconstruction of retinal histology images to track patterns of ganglion cell loss

Publications

Nonarath H, Hall, AE, SenthilKumar G, el al. (2021). 670nm Photobiomodulation Modulates Bioenergetics And Oxidative Stress, Decreasing Inflammatory Mediator Production In An In Vitro Model Of Diabetic Retinopathy. Research Square, Pre-Print. https://doi.org/10.21203/rs.3.rs-185179/v1

SenthilKumar G, Fisher MM, Skiba JH, et al. (2020). FGFR Inhibition Enhances Sensitivity to Radiation in Non-Small Cell Lung Cancer. Mol Cancer Ther, 19(6), 1255-1265. doi:10.1158/1535-7163.MCT-19-0931

Fisher MM, SenthilKumar G, Hu R, et al. (2020). Fibroblast Growth Factor Receptors as Targets for Radiosensitization in Head and Neck Squamous Cell Carcinomas. International Journal of Radiation Oncology, Biology, Physics. doi:10.1016/j.ijrobp.2020.03.040

Schlaak RA, SenthilKumar G, Boerma M, Bergom C. (2020). Advances in Preclinical Research Models of Radiation-Induced Cardiac Toxicity. Cancers (Basel), 12(2). doi:10.3390/cancers12020415

Schlaak RA, Frei A, SenthilKumar G, et al. (2020). Differences in Expression of Mitochondrial Complexes Due to Genetic Variants May Alter Sensitivity to Radiation-Induced Cardiac Dysfunction. Front Cardiovasc Med, 7, 23. doi:10.3389/fcvm.2020.00023

SenthilKumar G, Francis DM, Baschnagel, AM. (2019). Fibroblast growth factor receptor as therapeutic targets in head and neck squamous cell carcinomas. In Improving the Therapeutic Ratio in Head and Neck Cancer. (Vol. 6, pp. 235-262): Academic Press. Elsevier.

Francis DM, SenthilKumar G, Ko HC, Baschnagel AM. (2019). The MET receptor as a therapeutic target in head and neck squamous cell carcinomas. In Improving the Therapeutic Ratio in Head and Neck Cancer. (Vol. 6, pp. 263-280): Academic Press. Elsevier.

SenthilKumar G, Skiba JH, Kimple RJ. (2019). High-throughput quantitative detection of basal autophagy and autophagic flux using image cytometry. Biotechniques, 67(2), 70-73. doi:10.2144/btn-2019-0044

Meeting Abstracts

SenthilKumar G, Cole KE, Ellinas E. Why are women underrepresented in healthcare leadership? Center for the Advancement of Women in Science and Medicine Symposium, Medical College of Wisconsin, Milwaukee, WI, USA. March 2022. Virtual. [Poster, AWSM Symposium Education Session Winner]

Cole KE, SenthilKumar G, Treat R, Farkas A, Ellinas E. Designing a Self-Directed, Online Module to Promote Student Leadership and Intentional Involvement. Innovations in Medical Education Online Conference, Keck School of Medicine of University of Southern California, CA, USA. February 2022. Virtual. [Poster Presenter]

SenthilKumar G, Cole KE, He Y, Stark K, Craig T, Meurer J. Student Leadership Development Initiative: A Model for Training Medical Students Around the World. Innovations in Medical Education Online Conference, Keck School of Medicine of University of Southern California, CA, USA. February 2022. Virtual. [Poster]

Cole K* & SenthilKumar G*. Designing a leadership curriculum for medical students that teaches students to be influencers. Innovations in Healthcare Education Research Conference, Medical College of Wisconsin, Milwaukee, WI, USA. September 2021. Virtual. [Poster Presenter]

Senthilkumar G, Cole, KE, Fritz JD. Does Emotional Intelligence Matter for Medical Professionals? How Can We Foster It? AAMC 2021 GSA-OSR Spring Meeting. April 2021. [Oral Poster Presenter].

Senthilkumar G, Rokkas CK, Linsky PL. A functional, subcarinal paraganglioma adherent to the left atrial wall and supplied by large branches of the coronary and bronchial arteries. American College of Physicians Wisconsin Chapter. September 2020. [Poster Presenter]. American College of Physicians National Abstract Competition Winner. May 2020. [Oral Presentation].

Senthilkumar G, Gamblin TC, Clarke CN, Kimbrough C, et al. Characteristics of Exceptional vs Poor survivors in Colorectal Cancer Patients undergoing Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy. Society of Surgical Oncology 2021 Annual Meeting. March 2021. [Oral Poster Presenter].

Senthilkumar G, Thalji SZ, Clarke CN, Kimbrough C, et al. Characteristics and Outcomes of Exceptional vs Poor survivors in Disseminated Appendiceal Cancer Patients undergoing CRS/HIPEC – A Multi-institutional Analysis. Wisconsin Surgical Society 2020 Annual Meeting. November 2020. [Oral Presentation]. 16th Annual Academic Surgical Congress. February 2021. [Quickshot Oral Presentation].

Senthilkumar G, Fernando D, Gamblin TC, et al. Validation of the AJCC 8th Edition Staging System for Appendiceal Cancer Using a Multi-institutional Cohort of Patients Treated with Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy (CRS/HIPEC). American College of Surgeons Clinical Congress 2020. October 2020. [Oral Presentation]

Fernando D, Senthilkumar G, Clarke CN, et al. Role of Cytoreduction and Hyperthermic Intraperitoneal Chemotherapy (CRS/HIPEC) in the treatment of Peritoneal Carcinomatosis from Small Bowel Adenocarcinoma: A Systematic Review. American College of Surgeons Clinical Congress 2020. October 2020. [Poster]

Lee YS, Skiba J, Senthilkumar G, et al. Inhibition of radiation-induced autophagy improves control of head and neck squamous cell carcinoma. International Journal of Radiation Oncology Biology Physics. March 2020. Abstract 323. [Poster]

Senthilkumar G, Miller M, Fisher MM, et al. Radiosensitization of head and neck cancer by FGFR inhibition. American Association of Cancer Research 2019 Proceedings. Abstract 2929. April 2019. [Poster]

Miller M, Fisher MM, Senthilkumar G, et al. Evaluation of the pan-FGFR inhibitor AZD4547 with radiation in non-small cell lung cancer. American Association of Cancer Research 2019 Proceedings. Abstract 2924. April 2019. [Poster]

Eckers J, Skiba J, Senthilkumar G, et al. Autophagy contributed to therapeutic resistance in head and neck cancer. American Association of Cancer Research 2018 Proceedings. Abstract 1344. [Poster]

General Interests

Running, drawing/painting, boxing, trying new local restaurants, guitar