MSTP students in the Sahoo lab
Medical Scientist Training Program
Hayley Powers

Hayley Powers, PhD

M3 Student

Faculty Advisor

  • Daisy Sahoo, PhD, Biochemistry

Locations

  • Medical Scientist Training Program

Contact Information

Education

BS, Biology, Biomedical Concentration, University of Wisconsin-La Crosse, 2016

Research Interests

Cholesterol clearance, structural biology, cardiovascular disease, endocrinology, cardiology

Research Experience

Medical College of Wisconsin, 2018-2023
Advisor: Daisy Sahoo, PhD
Project: Identification of structural features of SR-BI that facilitate HDL-cholesterol clearance (F30HL151048)

University of Wisconsin-La Crosse, 2014-2016
Advisor: Margaret Maher
Project: AGEs, nutrient uptake, and the use of enzymatic supplements

Medical College of Wisconsin, 2015
Advisor: Allison Ebert
Project: Derivation of serotonergic neurons from induced pluripotent stem cells (iPSCs)

Publications

Dai W, Zhang H, Lund H, Zhang Z, Castleberry M, Rodriguez M, Kuriakose G, Gupta S, Lewandowska M, Powers HR, Valmiki S, Zhu J, Shapiro AD, Hussain MM, López JA, Sorci-Thomas MG, Silverstein RL, Ginsberg HN, Sahoo D, Tabas I, Zheng Z. Intracellular tPA-PAI-1 interaction determines VLDL assembly in hepatocytes. Science. 2023 Sep;381(6661):eadh5207. doi: 10.1126/science.adh5207. Epub 2023 Sep 1. PMID: 37651538.

Powers HR, Jenjak SE, Volkman BF, Sahoo D. Development and validation of a purification system for functional full-length human SR-B1 and CD36. J Biol Chem. 2023 Aug 23;299(10):105187. doi: 10.1016/j.jbc.2023.105187. Epub ahead of print. PMID: 37625590; PMCID: PMC10509710.

Powers HR, Sahoo D. SR-B1's Next Top Model: Structural Perspectives on the Functions of the HDL Receptor. Curr Atheroscler Rep. 2022 Apr;24(4):277-288. PMID: 35107765.

Schill RL, Knaack DA, Powers HR, Chen Y, Yang M, Schill DJ, Silverstein RL, Sahoo D. Modification of HDL by Reactive Aldehydes Alters Select Cardioprotective Functions of HDL in Macrophages. FEBS J. 2020 Feb;287(4):695-707. PMID: 31386799. 

Meeting Abstracts

Powers HR & Sahoo D. Novel Human Variants of SR-B1 Impact HDL-Cholesterol Clearance. Oral presentation at HDL Workshop, Boston, MA 2023.

Powers HR & Sahoo D. Novel Human Variants of SR-B1 Impact HDL-Cholesterol Clearance. Poster presentation at Vascular Discovery, Boston, MA, May 2023.

Powers HR, Jenjak SE, Volkman BF, Sahoo D. A Tale of Two Scavenger Receptors: Structure-Function Relationships of Purified SR-B1 and CD36. Oral presentation at Lipoprotein Metabolism Gordon Research Symposium, Southbridge, MA May 2022.

Powers HR, Jenjak SE, Volkman BF, Sahoo D. Selected abstract of excellence. Into the Wormhole: Understanding SR-B1's Cholesterol Transport Functions Through Structural Studies. Oral presentation at Vascular Discovery, Seattle, WA, May 2022. https://doi.org/10.1161/atvb.42.suppl_1.119

Powers HR, Jenjak SE, Volkman BF, Sahoo D. Into the Wormhole: Understanding SR-B1's Cholesterol Transport Functions Through Structural Studies. Poster presentation at Vascular Discovery, Seattle, WA, May 2022. https://doi.org/10.1161/atvb.42.suppl_1.206

Powers HR, Jenjak SE, Volkman BF, Sahoo D A Tale of Two Scavenger Receptors: Structure-Function Relationships of Purified SR-B1 and CD36. Poster presentation at American Society for Biochemistry and Molecular Biology (ASBMB)/Experimental Biology, Philadelphia, PA, April 2022. https://doi.org/10.1096/fasebj.2022.36.S1.R5661

Powers HR, Jenjak SE, Volkman BF, Sahoo D. Building a Structurally Sound System to Understand SR-BI Function. Poster presentation at Vascular Discovery, Virtual Conference, September 2021. https://doi.org/10.1161/atvb.41.suppl_1.P115

Powers HR, Jenjak SE, Volkman BF, Sahoo D. Bugging Out Over SR-BI's Structure Function Relationships. Poster presentation at 36th Annual MD/PhD Student Conference, Virtual, July 2021.

Powers HR, Jenjak SE, Volkman BF, Sahoo D. Developing a Purification System to Assess SR-BI Structure and Function. Poster presentation at American Society for Biochemistry and Molecular Biology (ASBMB)/Experimental Biology, Virtual, April 2021. https://doi.org/10.1096/fasebj.2021.35.S1.02333

Powers HR, Proudfoot SC, Feix JB, Sahoo D. (2020, May 5-7). Utilizing Nanodiscs to Model Membrane Interactions with SR-BI [Poster presentation]. Vascular Discovery, Chicago, IL, United States.

Powers HR, Proudfoot SC, Feix JB, Sahoo D. (2020, March 6). Utilizing Nanodiscs to Model Membrane Interactions with SR-BI [Poster presentation]. Department of Medicine Research Retreat, Milwaukee, WI, United States.

Powers HR, Proudfoot SC, Feix JB, Sahoo D. (2019, October 18). Utilizing Nanodiscs to Model Membrane Interactions with SR-BI [Poster presentation]. Cardiovascular Center Research Retreat, Milwaukee, WI, United States.

Powers HR. Selected abstract of excellence. Utilizing Nanodiscs to Model Membrane Interactions with SR-BI. Oral presentation at Vascular Discovery, Virtual, Mat 2020. https://doi.org/10.1161/atvb.41.suppl_1.P115

Powers HR, Breunig A, Verissimo F, Silvamen T, Oliveira A, De Oliveira M, De Araujo Lima S, Maher, M. Serum Advanced Glycation End Products (AGE) of Humans before and after Consumption of an AGE-Rich Meal. Poster presentation at Experimental Biology, San Diego, CA April 2016. https://faseb.onlinelibrary.wiley.com/doi/abs/10.1096/fasebj.30.1_supplement.907.16  

General Interests

Social justice, traveling, tennis, concerts, weightlifting, and reading