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Medical Scientist Training Program

Medical Scientist Training Program

Karina Bursch

G2 Student

Faculty Advisor

Brian Smith, PhD, Biochemistry

Locations

Medical Scientist Training Program

Contact Information

kbursch@mcw.edu

Education

BS, Biochemistry, The Catholic University of America, 2019

Research Interests

Cancer Biology, Immunology, Biochemistry

Research Experience

Medical College of Wisconsin, 2021-present
Advisor: Brian Smith, PhD
Project: Polybromo-1 (PBRM1) bromodomain missense mutations in clear cell renal cell carcinoma (ccRCC) vascular signaling pathways

The Catholic University of America, January 2017- May 2019
Advisor: Byung Min (Justin) Chung, PhD
Project: Elucidating the role of Keratin 19 (K19) in the proliferation and migration of MCF7 breast cancer cells.

MD Anderson Cancer Center, June 2018-August 2018
Advisor: Powel Brown, MD, PhD
Project: Determining the effect of the rexinoid IRX 4204 on the proliferation of a panel of breast cancer cell lines.

University of Minnesota, June 2017-August 2017
Advisor: Gregory Vercellotti, MD, FACP
Project: Characterizing the heme binding site on the MD-2/TLR4 transmembrane protein complex.

Publications

Khan M, Roddy JT, Hernandez JR, Bursch K, et al. Revisiting biochemistry: severe euglycemic ketoacidosis in the setting of IDH-inhibitor therapy for AML. Br J Haematol. 2021 Jun 7. doi: 10.1111/bjh.17576. Epub ahead of print. PMID: 34101165.

Alsharif S, Sharma P, Bursch K, et al. Keratin 19 maintains E-cadherin localization at the cell surface and stabilizes cell-cell adhesion of MCF7 cells. Cell Adh Migr. 2021 Dec;15(1):1-17. doi: 10.1080/19336918.2020.1868694. PMID: 33393839; PMCID: PMC7801129.

Sharma P, Alsharif S, Bursch K, Parvathaneni S, Anastasakis DG, Chahine J, Fallatah A, Nicolas K, Sharma S, Hafner M, Kallakury B & Chung BM. Keratin 19 regulates cell cycle pathway and sensitivity of breast cancer cells to CDK inhibitors. Scientific Reports 9, 14650 (2019).

General Interests

Playing cello and piano, traveling, running, and baking