Research Collaborate Lab Bench

Medical Scientist Training Program

Kelsey Meacham

Kelsey Meacham

G3 Student

Faculty Advisor

  • Blake Hill, PhD, Biochemistry

Locations

  • Medical Scientist Training Program

Contact Information

Education

BS, Biological Sciences, University of Alaska-Anchorage, 2016

Research Interests

Protein structure and function, structure-based drug design, mitochondrial dynamics, and cellular metabolism

Research Experience

Medical College of Wisconsin, 2019-present
Advisor: Blake Hill, PhD
Project: Determining the role of Fis1 in stress-induced mitochondrial fission – TL1 funded

University of Alaska-Anchorage, 2014-2016
Advisor: Jason Burkhead, PhD
Project: Altered zinc ion levels and transporter expression indicate that high liver copper disrupts zinc metabolism in the Atp7b -/- mouse model of Wilson Disease.

University of Alaska-Anchorage, 2015-2016
Advisor: Jason Burkhead, PhD
Project: The prevalence and role of copper deficiency in clinical liver disease

Publications

Ihenacho UK, Meacham KA, Harwig MC, Widlansky ME, Hill RB. Mitochondrial Fission Protein 1: Emerging Roles in Organellar Form and Function in Health and Disease. Front Endocrinol (Lausanne). 2021 Mar 25;12:660095. doi: 10.3389/fendo.2021.660095. PMID: 33841340; PMCID: PMC8027123.

Meacham, K. A., Cortes, M. P., Wiggins, E. M., Maass, A., Latorre, M., Ralle, M., & Burkhead, J. L. (2018). Altered zinc balance in the Atp7b−/− mouse reveals a mechanism of copper toxicity in Wilson disease. Metallomics, 2018(11), 1595-1606. doi: 10.1039/C8MT00199E

Meeting Abstracts

Meacham, KA, Egner, JM, Harwig, MC, Tessmer., MH, Noey, EL, Ihenacho, UK, Peterson, FP, Widlansky, ME, Hill, RB Structural studies of human Fis1 reveals a dynamic region important for Drp1 recruitment and mitochondrial fission. PDB50: A Special Symposium Celebrating the 50th Anniversary of the Protein Data Bank, Virtual, May 2021.

Meacham, KA, Paintsil, E, Egner, JM, Wang, J, Puppala, V, Hofeld, B, Hill, RB, Widlansky, ME Suppressing or blocking Fis1 reverses diabetic endothelial dysfunction in human resistance arteries. 2021 Association for Clinical and Translational Science, Virtual, March 2021.

Meacham, KA, Paintsil, E, Egner, JM, Wang, J, Puppala, V, Hofeld, B, Hill, RB, Widlansky, ME Suppressing or blocking Fis1 reverses diabetic endothelial dysfunction in human resistance arteries. 2021 Annual Graduate School Research Poster Session, Milwaukee, WI, February 2021

Meacham KA, Egner JM, Harwig MC, Widlansky ME, Hill RB. (2019, November). Fis1 regulation of mitochondrial fission. 2019 Annual Graduate School Research Poster Session, Milwaukee, WI.

Meacham KA, Posey A, Bagheri M, Harwig M, Kennedy N, Hilser V, Harden J, Hill B. (2019, September). The variable domain of the mitochondrial fission mechanoenzyme Drp1 promotes liquid-liquid phase separation. NHLBI Mitochondrial Biology Symposium, Bethesda, MD.

Meacham KA, Cortes MP, Maass A, Latorre M, Ralle M, Burkhead J L. (2016, July). Multi-metal dyshomeostasis in the Atp7b -/- mouse model of Wilson disease. St. Jude National Undergraduate Research Symposium, Memphis, TN, July 2016

Altered zinc ion levels and transporter expression indicate that high liver copper disrupts zinc metabolism in the Atp7b -/- mouse model of Wilson Disease. Kelsey Meacham and Jason Burkhead American Society for Biochemistry and Molecular Biology Annual Meeting, April 2016 San Diego, CA

General Interests

Cooking, baking, home-brewing and gardening