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MSTP students in the Sahoo lab

Medical Scientist Training Program

Matthew Brown

M2 Student

Locations

Medical Scientist Training Program

Contact Information

maabrown@mcw.edu

Education

BA, Biochemistry, University of Colorado Boulder, 2020

Research Interests

Infectious Diseases, Virology, and Immunology

Research Experience

HIV Dynamics and Replication Program, National Cancer Institute, 2021- 2022
Advisor: Wei-Shau Hu, PhD
Projects: 1) Using HIV-1 frameshifting to improve methods to study HIV-1 genome packaging and particle formation, 2) Developing a platform for high-throughput screening of compounds antagonistic to coronavirus proteases

University of Colorado Boulder, 2018-2020
Advisor: Marcelo Sousa, PhD
Project: Determining dynamics of the BamA beta-barrel seam in Gram-negative bacteria

Publications

Duchon A, Santos S, Chen J, Brown M, Nikolaitchik OA, Tai S, Chao JA, Freed EO, Pathak VK, Hu WS. Plasma Membrane Anchoring and Gag:Gag Multimerization on Viral RNA Are Critical Properties of HIV-1 Gag Required To Mediate Efficient Genome Packaging. mBio. 2021 Dec 21;12(6):e0325421. doi: 10.1128/mbio.03254-21. Epub 2021 Dec 7. PMID: 34872357; PMCID: PMC8649766.

Meeting Abstracts

Brown MA. Development of a system to simultaneously express two forms of Gag using HIV-1 frameshifting. Presented at National Cancer Institute's Center for Cancer Research Fellows and Young Investigators Seminar Series, Virtual, February 2022.

Brown MA, Doerner PA, and Sousa MC. A Comparison of in vivo and in vitro BamA Barrel Seam Dynamics. Presented at Biophysical Society Annual Meeting, San Diego, CA, February 2020.

General Interests

I enjoy activities outdoors like skiing, hiking, and camping. I also enjoy reading good books and playing chess.