Research Collaborate Lab Bench

Medical Scientist Training Program

Michael Olp

Michael Olp, PhD

M4 Student

Faculty Advisor

  • Brian Smith, PhD, Biochemistry

Locations

  • Medical Scientist Training Program

Contact Information

Education

PhD, Medical College of Wisconsin, 2019
BA, Chemistry, Washington University, St. Louis, MO, 2013

Research Interests

Applying biochemical, chemical biological, biophysical, and computational methods toward understanding and manipulating the causes and effects of human disease.

Research Experience

Medical College of Wisconsin, 2015-2019
Advisor: Brian Smith, PhD
Project: Investigated the role of physical interactions between chromatin and bromodomain and extraterminal domain (BET) proteins in epigenetic regulation of gene transcription

Washington University in St. Louis, 2011-2013
Advisor: Joshua Maurer, PhD
Project: Used supported lipid bilayers to study mechanisms of antimicrobial peptide insertion into cellular membranes

Publications

Olp MD, Kalous KS, Smith BC. ICEKAT: an interactive online tool for calculating initial rates from continuous enzyme kinetic traces. BMC Bioinformatics. 2020; 21(1):186. Published 2020 May 14. doi:10.1186/s12859-020-3513-y

Olp MD, Sprague DJ, Goetz CJ, Kathman SG, Wynia-Smith SL, Shishodia S, Summers SB, Xu Z, Statsyuk AV, Smith BC. Covalent-Fragment Screening of BRD4 Identifies a Ligandable Site Orthogonal to the Acetyl-Lysine Binding Sites. ACS Chem Biol. 2020; 15(4):10361049. doi:10.1021/acschembio.0c00058

McCusker P, Mian MY, Li G, Olp MD, Tiruveedhula VVNPB, Rashid F, Golani LK, Verma RS, Smith BC, Cook JM, Chan JD. Non-sedating benzodiazepines cause paralysis and tissue damage in the parasitic blood fluke Schistosoma mansoni. PLoS Negl Trop Dis. 2019; 13(11):e0007826

Egner JM, Jensen DR, Olp MD, Kennedy NW, Volkman BF, Peterson FC, Smith BC, Hill RB. Development and Validation of 2D Difference Intensity Analysis for Chemical Library Screening by Protein-Detected NMR Spectroscopy. Chembiochem. 2018; 19(5):448458. doi:10.1002/cbic.201700386

Olp MD, Zhu N, Smith BC. Metabolically Derived Lysine Acylations and Neighboring Modifications Tune the Binding of the BET Bromodomains to Histone H4. Biochemistry. 2017; 56(41):54855495.doi:10.1021/acs.biochem.7b00595

Kalous KS, Wynia-Smith SL, Olp MD, Smith BC. Mechanism of Sirt1 NAD+-dependent Protein Deacetylase Inhibition by Cysteine S-Nitrosation. J Biol Chem. 2016; 291(49):2539825410. doi:10.1074/jbc.M116.754655

Meeting Abstracts

Olp MD, Sprague DJ, Kathman SG, Statsyuk AV, Smith BC. (July 2018). Discovering BRD4-Selective Inhibitors Using a Novel Fragment Screening Strategy. Presented at: Keystone National MD/PhD Student Conference; Keystone, CO

Olp MD, Zhu N, Smith BC. (April 2017). Discovering Selectivity in BET Bromodomain Epigenetic Regulation. Presented at: American Society for Biochemistry and Molecular Biology Annual Meeting. Chicago, IL

Olp MD, Kathman SG, Statsyuk AV, Smith BC. (Nov 2016). Engineering Selective Chemical Probesto Modulate BRD4 Epigenetic Function. Presented at: Chicago Area NMR Discussion Group Meeting. Milwaukee, WI

General Interests

Live music, physical fitness, programming and computational modelling