Ryan Brown

CD8 T cells, T cell receptor, high throughput sequencing, cancer immunology, bioinformatics

Research Experience

Medical College of Wisconsin, 2022-present
Advisor: Weiguo Cui, PhD
Project: BCG-CAR empowers adoptive cell therapy to treat bladder cancer

UW-Madison, 2017 – 2020
Advisor: Zach Morris, MD/PhD and Ravi Patel, MD/PhD
Project: Examining the efficacy of bempegaldesleukin and anti-CTLA-4 at metastatic sites after combination with high dose radiation therapy in a preclinical non-small cell lung cancer model

Cambridge University, 2019
Advisor: Emma Rawlins, PhD
Project: Exploring human embryo stem cell alveolar differentiation

Publications

Kharel A, Shen J, Brown R, Chen Y, Nguyen C, Alson D, Bluemn T, Fan J, Gai K, Zhang B, Kudek M, Zhu N, Cui W. Loss of PBAF promotes expansion and effector differentiation of CD8+ T cells during chronic viral infection and cancer. Cell Rep. 2023 Jun 16;42(6):112649. doi: 10.1016/j.celrep.2023.112649. Epub ahead of print. PMID: 37330910.

Thareja SK, Anfinson M, Cavanaugh M, Kim MS, Lamberton P, Radandt J, Brown R, Liang HL, Stamm K, Afzal MZ, Strande J, Frommelt MA, Lough JW, Fitts RH, Mitchell ME, Tomita-Mitchell A. Altered contractility, Ca2+ transients, and cell morphology seen in a patient-specific iPSC-CM model of Ebstein's anomaly with left ventricular noncompaction. Am J Physiol Heart Circ Physiol. 2023 Jul 1;325(1):H149-H162. doi: 10.1152/ajpheart.00658.2022. Epub 2023 May 19. PMID: 37204873; PMCID: PMC10312315.

Bates AM, Brown RJ, Pieper AA, Zangl LM, et al. Combination of Bempegaldesleukin and Anti-CTLA-4 Prevents Metastatic Dissemination After Primary Resection or Radiotherapy in a Preclinical Model of Non-Small Cell Lung Cancer. Front Oncol. 2021 Apr 15;11:645352. doi: 10.3389/fonc.2021.645352. PMID: 33937052; PMCID: PMC8083981. 

Meeting Abstracts

Brown RJ, Amber Bates, Zangl L, et al. Combination of bempegaldesleukin and anti-CTLA-4 prevents metastatic dissemination after primary surgery or radiation therapy in a preclinical model of non-small cell lung cancer. Poster Presentation at: AACR, June 2020, San Diego CA.

Brown RJ, Hernandez R, Grudzinski JJ, Zangl L, Arthur I, Pieper A, Marsh IR, Bednarz B, Weichert J, Sondel PM, Morris ZS, and Patel R. Molecular radionucleotide therapy and anti-CTLA-4 prevent spontaneous metastases in a preclinical Lewis lung carcinoma model. Poster Presentation at: ASTRO, September 2019, Chicago IL.

General Interests

Movies, lifting weights, news