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Dr. Candice Klug Receives Grant to Investigate Bacterial Proteins and Develop EPR Instrumentation

September 1, 2025

Candice Klug, PhD, James S. Hyde Professor of Biophysics, was awarded a five-year $2.22 million Maximizing Investigators’ Research Award (R35) grant titled "Functional dynamics of essential bacterial proteins and EPR technology development" from the National Institute of General Medical Sciences.Candice Klug, PhD

Detailed knowledge of protein structure and dynamics is critical to understanding their function so that effective and directed therapeutics can be developed to improve human health. For example, society is in dire need of novel antibiotics against drug-resistant bacteria. This proposal integrates Dr. Klug’s expertise in and current research on protein structure and functional dynamics related to antibiotic resistance in Gram-negative bacteria and the development of transformative electron paramagnetic resonance (EPR) spectroscopy technologies for biomedically relevant structural biology applications.

For this project, Dr. Klug’s lab will apply an array of biophysical, computational, and microbiological approaches to obtain a better understanding of essential bacterial proteins as a foundation for the future development of inventive antibiotics against important pathogenic bacteria such as Escherichia coli. In addition, the Klug lab will develop state-of-the-art biomedical EPR spectroscopy instrumentation to provide a transformative increase in research throughput that will enable a wide range of new applications including structural biology, metalloprotein research, redox biology, rational drug design, and clinical diagnostics for a range of human diseases.

Tagged: Biophysics National Biomedical EPR Center Research – Basic Sciences

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