About our Research Programs

The research programs of the Asthma/Allergy and Clinical Immunology Division include investigations in rhinitis, asthma, hypersensitivity pneumonitis, aspergillus mediated allergic diseases, food allergy, and primary immunodeficiencies.

View our Allergy and Clinical Immunology Specialists

Children's Research Institute

Current Research Studies

  1. Pediatric and Adult Asthma Trials:
    • Phase IIIb Multi-center, Randomized, Double¬-Blind, Placebo-¬Controlled Study of Xolair® in Subjects with Moderate to Severe Persistent Asthma Who are Inadequately Controlled With High-Dose Inhaled Corticosteroids and Long-Acting Beta-Agonist
    • Epidemiologic Study of Xolair® (Omalizumab): Evaluating Clinical Effectiveness and Long-Term Safety in Patients With Moderate to Severe Asthma (EXCELS)
    • A 1 Year, Randomized, Double Blind, Parallel-Group, Placebo-Controlled, Multicenter Evaluation of Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of Omalizumab in Children (6 - <12 years) With Moderate-Severe, Persistent, Inadequately Controlled Allergic Asthma.
    • Study of Acid Reflux in Children with Asthma (SARCA): The purpose of this NIH funded research is to test the hypothesis that children with symptomatic asthma will have improved asthma control with medical treatment of esophageal reflux with the proton-pump inhibitor, lansoprazole, as compared to children treated with placebo.
  2. Food Allergy: We have ongoing clinical research projects in the area of food allergies. Current studies include:
    • Detection of Peanut Protein in Serum and Saliva
    • Determination Of Minimum And Non-Provoking Doses Of Soy Protein In Soy Allergic Individuals
  3. Primary Immunodeficiency
    • Pilot Program to Screen Newborns for Severe Combined Immune Deficiency (SCID) in Wisconsin: The purpose of this research is to develop a collaborative program with the WI State Department of Hygiene to screen all newborns in the State of WI for SCID. We will extract DNA from blood spots on newborn screening cards and use real time PCR to quantitate T cell receptor circles to screen for SCID.
    • Lymphoproliferative Disorders in Primary Immunodeficiencies: the purpose of this research is to determine if transforming viral infections lead to lymphoproliferative disorders in patients with primary immune deficiencies.

Recent Department Publications

  • BMJ Best Practice: Point of Care. Severe Combined Immune Deficiency. Verbsky J and Routes JM. 2015.
  • Routes JM. Pulmonary complications of primary immunodeficiencies. Textbook of Respiratory Medicine, 6th Edition. Mason RJ, Broaddus VC, Martin T, King Jr. T, Schraufnagel DMD, Murray JF, Nadel JA (editors). 2015.
  • Rao N, Mackinnon AC, Routes JM. Granulomatous and lymphocytic interstitial lung disease: a spectrum of pulmonary histopathologic lesions in common variable immunodeficiency--histologic and immunohistochemical analyses of 16 cases. Hum Pathol. 2015 Sep;46(9):1306-14. doi: 10.1016/j.humpath.2015.05.011. Epub 2015 Jun 1. PMID: 26138782
  • Buelow BJ, Verbsky JW, Routes JM. Newborn Screening for SCID: Lessons Learned. Expert Rev Hematol. Epub 2016 May 9. PMID: 27139719
  • Marshall GD Jr, Grayson MH, Ellis AK, Hsieh FH, Oppenheimer J, Desai M, Lieberman JA, Greenhawt M, Montanaro A, Bielory L. The year in review: the best of 2015 in the Annals. Ann Allergy Asthma Immunol. 2016 Jan;116(1):2-8. PMID: 26707769
  • Bonilla FA, Barlan I, Chapel H, Costa-Carvalho BT, Cunningham-Rundles C, de la Morena MT, Espinosa-Rosales FJ, Hammarstrom L, Nonoyama S, Quinti I, Routes JM, Tang ML, Warnatz K. International Consensus Document (ICON): Common Variable Immunodeficiency Disorders. J Allergy Clin Immunol Pract. 2016 Jan-Feb;4(1):38-59. doi: 10.1016/j.jaip.2015.07.025. PMID: 26563668
  • Kelly BT, Grayson MH. Immunoglobulin E, what is it good for? Ann Allergy Asthma Immunol. 2016 Mar;116(3):183-7 PMID: 26945494
  • Korrer MJ, Zhang Y, Routes JM. Correction: Possible Role of Arginase-1 in Concomitant Tumor Immunity. PLoS One. 2016 Mar 31;11(3)e0153122. doi: 10.1371/journal.pone.0153122. PMID: 27031640
  • Routes JM, Costa-Carvalho BT, Grimbacher B, Paris K, Ochs HD, Filipovich A, Hintermeyer M, de Melo KM, Worman S, Ito D, Ye X, Bonnet P, Li-McLeod J. Health-Related Quality of Life and Health Resource Utilization in Patients with Primary Immunodeficiency Disease Prior to and Following 12 Months of Immunoglobulin G Treatment. J Clin Immunol. 2016 Apr 18. PMID: 27091140
  • Gallagher K, Adams J, Hintermeyer M, Torgerson TR, Lopez-Guisa J, Ochs HD, Szabo S, Salib M, Verbsky J, Routes J. X-linked Hyper IgM Syndrome Presenting as Pulmonary Alveolar Proteinosis. J Clin Immunol. 2016 Aug;36(6):564-70. doi: 10.1007/s10875-016-0307-0. Epub 2016 Jun 20. PMID: 27324886
  • de la Morena MT, Leonard D, Torgerson TR, Cabral-Marques O, Slatter M, Aghamohammadi A, Chandra S, Murguia-Favela L, Bonilla FA, Kanariou M, Damrongwatanasuk R, Kuo CY, Dvorak CC, Meyts I, Chen K, Kobrynski L, Kapoor N, Richter D, DiGiovanni D, Dhalla F, Farmaki E, Speckmann C, Español T, Shcherbina A, Hanson IC, Litzman J, Routes JM, Wong M, Fuleihan R, Seneviratne SL, Small TN, Janda A, Bezrodnik L, Seger R, Raccio AG, Edgar JD, Chou J, Abbott JK, van Montfrans J, González-Granado LI, Bunin N, Kutukculer N, Gray P, Seminario G, Pasic S, Aquino V, Wysocki C, Abolhassani H, Dorsey M, Cunningham-Rundles C, Knutsen AP, Sleasman J, Costa Carvalho BT, Condino-Neto A, Grunebaum E, Chapel H, Ochs HD, Filipovich A, Cowan M, Gennery A, Cant A, Notarangelo LD, Roifman CM. Long-term outcomes of 176 patients with X-linked hyper-IgM syndrome treated with or without hematopoietic cell transplantation. J Allergy Clin Immunol. 2016 Sep 30. pii: S0091-6749(16)30964-2. doi: 10.1016/j.jaci.2016.07.039. [Epub ahead of print] PMID: 27697500
  • Bonilla FA, Chapel H, Costa-Carvalho BT, Cunningham-Rundles C, de la Morena MT, Espinosa-Rosales FJ, Hammarström L, Nonoyama S, Quinti I, Routes JM, Tang ML, Warnatz K. Reply. J Allergy Clin Immunol Pract. 2016 Sep-Oct;4(5):1019-20.
  • Hartman H, Schneider K, Hintermeyer M, Bausch-Jurken M, Fuleihan R, Sullivan KE, Cunningham-Rundles C, Bonilla FA; USIDNET Consortium., Verbsky J, Routes J. Lack of Clinical Hypersensitivity to Penicillin Antibiotics in Common Variable Immunodeficiency. J Clin Immunol. 2016 Nov 22; Epub ahead of print. PMID: 27873106.
  • Perelygina L, Plotkin S, Russo P, Hautala T, Bonilla F, Ochs HD, Joshi A, Routes J, Patel K, Wehr C, Icenogle J, Sullivan KE. Rubella persistence in epidermal keratinocytes and granuloma M2 macrophages in patients with primary immunodeficiencies. J Allergy Clin Immunol. 2016 Nov;138(5):1436-1439.e11.
  • Routes JM, Verbsky JW. Immunodeficiency Presenting as an Undiagnosed Disease. Pediatr Clin North Am. 2017 Feb;64(1):27-37. doi: 10.1016/j.pcl.2016.08.007. Review. PMID: 27894450
  • Vyles D, Chiu A, Simpson P, Nimmer M, Adams J, Brousseau DC. Parent Reported Penicillin Allergy Symptoms in the Pediatric Emergency Department. Acad Pediatrics. Apr;17(3):251-255.
  • Vyles D, Adams J, Chiu A, Simpson Pippa, Nimmer M, Brousseau DC. Testing in Children with Low Risk Penicillin Allergy. Pediatrics. 2017, in press.
  • Bausch-Jurken MT, Verbsky JW, Gonzaga KA, Elms NP, Hintermeyer MK, Gauld SB, Routes JM. The Use of Salmonella Typhim Vaccine to Diagnose Antibody Deficiency. J Clin Immunol. 2017 Jun 7. doi: 10.1007/s10875-017-0406-6. [Epub ahead of print] PMID: 28589420
  • Chiu, A. and Volkman, K. Allergy chapter, Nelson Essentials of Pediatrics, 8th edition, Marcdante KJ, Kliegman RM, Jenson HG, Berhman RE (editors). Saunders Elsevier, in press.
  • Bausch-Jurken MT, Verbsky JW, Gonzaga KA, Elms NP, Hintermeyer MK, Gauld SB, Routes JM. J Clin Immunol. 2017 Jun 7. doi: 10.1007/s10875-017-0406-6. [Epub ahead of print] PMID:28589420