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Asthma/Allergy and Clinical Immunology

Medical College of Wisconsin Asthma/Allergy and Clinical Immunology Research Programs

The Division of Asthma, Allergy, and Immunology has a robust clinical trial portfolio. Clinical trials include studies related to Asthma, Hereditary Angioedema (HAE), Hypereosinophilic Syndrome (HES) and Primary Immunodeficiency. In addition, the Division also has funded asthma and primary immunodeficiency disease research.

Children's Research Institute

Current Research Studies

Pediatric and Adult Asthma Trials

Pediatric and Adult Asthma Trials

  • Phase IIIb Multi-center, Randomized, Double¬-Blind, Placebo-¬Controlled Study of Xolair® in Subjects with Moderate to Severe Persistent Asthma Who are Inadequately Controlled With High-Dose Inhaled Corticosteroids and Long-Acting Beta-Agonist
  • Epidemiologic Study of Xolair® (Omalizumab): Evaluating Clinical Effectiveness and Long-Term Safety in Patients With Moderate to Severe Asthma (EXCELS)
  • A 1 Year, Randomized, Double Blind, Parallel-Group, Placebo-Controlled, Multicenter Evaluation of Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of Omalizumab in Children (6 - <12 years) With Moderate-Severe, Persistent, Inadequately Controlled Allergic Asthma.
  • Study of Acid Reflux in Children with Asthma (SARCA): The purpose of this NIH funded research is to test the hypothesis that children with symptomatic asthma will have improved asthma control with medical treatment of esophageal reflux with the proton-pump inhibitor, lansoprazole, as compared to children treated with placebo.
Food Allergy

Food Allergy

We have ongoing clinical research projects in the area of food allergies. Current studies include:

  • Detection of Peanut Protein in Serum and Saliva
  • Determination Of Minimum And Non-Provoking Doses Of Soy Protein In Soy Allergic Individuals
Primary Immunodeficiency

Primary Immunodeficiency

  • Pilot Program to Screen Newborns for Severe Combined Immune Deficiency (SCID) in Wisconsin: The purpose of this research is to develop a collaborative program with the WI State Department of Hygiene to screen all newborns in the State of WI for SCID. We will extract DNA from blood spots on newborn screening cards and use real time PCR to quantitate T cell receptor circles to screen for SCID.
  • Lymphoproliferative Disorders in Primary Immunodeficiencies: the purpose of this research is to determine if transforming viral infections lead to lymphoproliferative disorders in patients with primary immune deficiencies.

Recent Department Publications

Publications of Asriani M. Chiu MD, Leslie M. Gimenez MD, Barry Joel Pelz MD, Joshua A. Steinberg MD and Heidi T. Zafra MD from the Faculty Collaboration Database

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