Research Programs
The research programs of the Asthma/Allergy and Clinical Immunology Division include investigations in rhinitis, asthma, hypersensitivity pneumonitis, aspergillus mediated allergic diseases, food allergy, and primary immunodeficiencies.
Current Research Studies
Pediatric and Adult Asthma Trials
- Phase IIIb Multi-center, Randomized, Double¬-Blind, Placebo-¬Controlled Study of Xolair® in Subjects with Moderate to Severe Persistent Asthma Who are Inadequately Controlled With High-Dose Inhaled Corticosteroids and Long-Acting Beta-Agonist
- Epidemiologic Study of Xolair® (Omalizumab): Evaluating Clinical Effectiveness and Long-Term Safety in Patients With Moderate to Severe Asthma (EXCELS)
- A 1 Year, Randomized, Double Blind, Parallel-Group, Placebo-Controlled, Multicenter Evaluation of Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of Omalizumab in Children (6 - <12 years) With Moderate-Severe, Persistent, Inadequately Controlled Allergic Asthma.
- Study of Acid Reflux in Children with Asthma (SARCA): The purpose of this NIH funded research is to test the hypothesis that children with symptomatic asthma will have improved asthma control with medical treatment of esophageal reflux with the proton-pump inhibitor, lansoprazole, as compared to children treated with placebo.
Food Allergy
We have ongoing clinical research projects in the area of food allergies. Current studies include:
- Detection of Peanut Protein in Serum and Saliva
- Determination Of Minimum And Non-Provoking Doses Of Soy Protein In Soy Allergic Individuals
Primary Immunodeficiency
- Pilot Program to Screen Newborns for Severe Combined Immune Deficiency (SCID) in Wisconsin: The purpose of this research is to develop a collaborative program with the WI State Department of Hygiene to screen all newborns in the State of WI for SCID. We will extract DNA from blood spots on newborn screening cards and use real time PCR to quantitate T cell receptor circles to screen for SCID.
- Lymphoproliferative Disorders in Primary Immunodeficiencies: the purpose of this research is to determine if transforming viral infections lead to lymphoproliferative disorders in patients with primary immune deficiencies.
Recent Department Publications
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When You Can't Find a Heartbeat.
(Buelow BJ, Buelow MW.) JAMA. 2019 Oct 15;322(15):1453-1454.
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Oral amoxicillin challenges in low-risk children during a pediatric emergency department visit.
(Vyles D, Chiu A, Routes J, Castells M, Phillips EJ, Visotcky A, Fraser R, Pezzin L, Brousseau DC.) J Allergy Clin Immunol Pract. 2019 Oct 03.
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(Marsh RA, Leiding JW, Logan BR, Griffith LM, Arnold DE, Haddad E, Falcone EL, Yin Z, Patel K, Arbuckle E, Bleesing JJ, Sullivan KE, Heimall J, Burroughs LM, Skoda-Smith S, Chandrakasan S, Yu LC, Oshrine BR, Cuvelier GDE, Thakar MS, Chen K, Teira P, Shenoy S, Phelan R, Forbes LR, Chellapandian D, Dávila Saldaña BJ, Shah AJ, Weinacht KG, Joshi A, Boulad F, Quigg TC, Dvorak CC, Grossman D, Torgerson T, Graham P, Prasad V, Knutsen A, Chong H, Miller H, de la Morena MT, DeSantes K, Cowan MJ, Notarangelo LD, Kohn DB, Stenger E, Pai SY, Routes JM, Puck JM, Kapoor N, Pulsipher MA, Malech HL, Parikh S, Kang EM, submitted on behalf of the Primary Immune Deficiency Treatment Consortium.) J Clin Immunol. 2019 Oct;39(7):653-667.
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(Yang C, Siebert JR, Burns R, Gerbec ZJ, Bonacci B, Rymaszewski A, Rau M, Riese MJ, Rao S, Carlson KS, Routes JM, Verbsky JW, Thakar MS, Malarkannan S.) Nat Commun. 2019 Sep 02;10(1):3931.
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Reported Knowledge and Management of Potential Penicillin Allergy in Children.
(Vyles D, Mistry RD, Heffner V, Drayna P, Chiu A, Visotcky A, Fraser R, Brousseau DC.) Acad Pediatr. 2019 Aug;19(6):684-690.
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Life-Threatening Allergies: Using a Patient-Engaged Approach.
(Gallagher JL, Rivera RD, Van Shepard K, Roushan T, Ahsan G, Ahamed SI, Chiu A, Jurken M, Simpson PM, Nugent M, Gobin KS, Wen CKF, Eldredge CE.) Telemed J E Health. 2019 04;25(4):319-325.
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E1A oncogene induced sensitization to NK cell induced apoptosis requires PIDD and Caspase-2.
(Radke JR, Routes JM, Cook JL.) Cell Death Discov. 2019;5:110.
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CTLA4 Message Reflects Pathway Disruption in Monogenic Disorders and Under Therapeutic Blockade.
(Garcia-Perez JE, Baxter RM, Kong DS, Tobin R, McCarter M, Routes JM, Verbsky J, Jordan MB, Dutmer CM, Hsieh EWY.) Front Immunol. 2019;10:998.
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X-linked agammaglobulinemia (XLA):Phenotype, diagnosis, and therapeutic challenges around the world.
(El-Sayed ZA, Abramova I, Aldave JC, Al-Herz W, Bezrodnik L, Boukari R, Bousfiha AA, Cancrini C, Condino-Neto A, Dbaibo G, Derfalvi B, Dogu F, Edgar JDM, Eley B, El-Owaidy RH, Espinosa-Padilla SE, Galal N, Haerynck F, Hanna-Wakim R, Hossny E, Ikinciogullari A, Kamal E, Kanegane H, Kechout N, Lau YL, Morio T, Moschese V, Neves JF, Ouederni M, Paganelli R, Paris K, Pignata C, Plebani A, Qamar FN, Qureshi S, Radhakrishnan N, Rezaei N, Rosario N, Routes J, Sanchez B, Sediva A, Seppanen MR, Serrano EG, Shcherbina A, Singh S, Siniah S, Spadaro G, Tang M, Vinet AM, Volokha A, Sullivan KE.) World Allergy Organ J. 2019;12(3):100018.
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(Bausch-Jurken MT, Hintermeyer M, Woodliff J, Chen S, Rymaszewski A, Verbsky J, Routes J.) J Clin Immunol. 2019 01;39(1):23-25.
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Newborn Screening for Severe Combined Immunodeficiency.
(Routes J, Verbsky J.) Curr Allergy Asthma Rep. 2018 05 10;18(6):34.
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Antibiotic Use After Removal of Penicillin Allergy Label.
(Vyles D, Chiu A, Routes J, Castells M, Phillips EJ, Kibicho J, Brousseau DC.) Pediatrics. 2018 05;141(5).
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(Radke JR, Figueroa I, Routes JM, Cook JL.) Cell Death Discov. 2018;4:35.
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The Lung in Primary Immunodeficiencies: New Concepts in Infection and Inflammation.
(Baumann U, Routes JM, Soler-Palacín P, Jolles S.) Front Immunol. 2018;9:1837.
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Allergy Testing in Children With Low-Risk Penicillin Allergy Symptoms.
(Vyles D, Adams J, Chiu A, Simpson P, Nimmer M, Brousseau DC.) Pediatrics. 2017 Aug;140(2).
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POL7085 or anti-CCL28 treatment inhibits development of post-paramyxoviral airway disease.
(Buelow BJ, Rohlfing M, Jung F, Douglas GJ, Grayson MH.) Immun Inflamm Dis. 2017 06;5(2):98-108.
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Parent-Reported Penicillin Allergy Symptoms in the Pediatric Emergency Department.
(Vyles D, Chiu A, Simpson P, Nimmer M, Adams J, Brousseau DC.) Acad Pediatr. 2017 04;17(3):251-255.
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IgE-associated food allergy alters the presentation of paediatric eosinophilic esophagitis.
(Pelz BJ, Wechsler JB, Amsden K, Johnson K, Singh AM, Wershil BK, Kagalwalla AF, Bryce PJ.) Clin Exp Allergy. 2016 11;46(11):1431-1440.
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Newborn screening for SCID: lessons learned.
(Buelow BJ, Verbsky JW, Routes JM.) Expert Rev Hematol. 2016 Jun;9(6):579-84.
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Pathophysiology of Food Allergy.
(Pelz BJ, Bryce PJ.) Pediatr Clin North Am. 2015 Dec;62(6):1363-75.
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(Buelow BJ, Kelly BT, Zafra HT, Kelly KJ.) J Allergy Clin Immunol Pract. 2015 Jul-Aug;3(4):597-8.
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Structure-function analysis of CCL28 in the development of post-viral asthma.
(Thomas MA, Buelow BJ, Nevins AM, Jones SE, Peterson FC, Gundry RL, Grayson MH, Volkman BF.) J Biol Chem. 2015 Feb 13;290(7):4528-36.
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Coronin-1A: immune deficiency in humans and mice.
(Punwani D, Pelz B, Yu J, Arva NC, Schafernak K, Kondratowicz K, Makhija M, Puck JM.) J Clin Immunol. 2015 Feb;35(2):100-7.
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Perception versus reality: the saga of inhaled asthma controller medication and fetal risk.
(Steinberg JA.) J Allergy Clin Immunol. 2015 Jan;135(1):131-2.
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Newborn screening for SCID: where are we now?
(Buelow BJ, Routes JM, Verbsky JW.) Expert Rev Clin Immunol. 2014 Dec;10(12):1649-57.
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(Miller EK, Avila PC, Khan YW, Word CR, Pelz BJ, Papadopoulos NG, Peebles RS Jr, Heymann PW, Microbes, Allergy, and Asthma Committee.) J Allergy Clin Immunol Pract. 2014 Sep-Oct;2(5):537-43.
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Egg baked in product open oral food challenges are safe in selected egg-allergic patients.
(Buelow BJ, Lee C, Zafra HT, Dasgupta M, Hoffmann RG, Vasudev M.) Allergy Rhinol (Providence). 2014 Jul;5(2):110-2.
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CD49d-expressing neutrophils differentiate atopic from nonatopic individuals.
(Sigua JA, Buelow B, Cheung DS, Buell E, Hunter D, Klancnik M, Grayson MH.) J Allergy Clin Immunol. 2014 Mar;133(3):901-4.e5.
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The changing face of allergy/immunology fellowship programs.
(Zafra H, Chiu A.) Ann Allergy Asthma Immunol. 2013 Nov;111(5):313-5.
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The value of an allergy and clinical immunology rotation at an academic tertiary medical center.
(Bauer CS, Chiu AM, Zafra HT, Gimenez LM, Nugent ML, Simpson PM, Vasudev M.) Ann Allergy Asthma Immunol. 2013 Jun;110(6):468-469.e9.
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Vocal cord dysfunction: an update.
(Gimenez LM, Zafra H.) Ann Allergy Asthma Immunol. 2011 Apr;106(4):267-74; quiz 275.
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Absence of mycobacterium avium subsp. paratuberculosis in Crohn's patients.
(Parrish NM, Radcliff RP, Brey BJ, Anderson JL, Clark DL Jr, Koziczkowski JJ, Ko CG, Goldberg ND, Brinker DA, Carlson RA, Dick JD, Ellingson JL.) Inflamm Bowel Dis. 2009 Apr;15(4):558-65.
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Nasal airway obstruction: allergy and otolaryngology perspectives.
(Shemirani NL, Rhee JS, Chiu AM.) Ann Allergy Asthma Immunol. 2008 Dec;101(6):593-8.
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Adverse reactions to orthodontic appliances in nickel-allergic patients.
(Volkman KK, Inda MJ, Reichl PG, Zacharisen MC.) Allergy Asthma Proc. 2007 Jul-Aug;28(4):480-4.
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Yacht-maker's lung: A case of hypersensitivity pneumonitis in yacht manufacturing.
(Volkman KK, Merrick JG, Zacharisen MC.) WMJ. 2006 Oct;105(7):47-50.
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(Brey BJ, Radcliff RP, Clark DL Jr, Ellingson JL.) Mol Cell Probes. 2006 Feb;20(1):51-9.
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Anaphylaxis: drug allergy, insect stings, and latex.
(Chiu AM, Kelly KJ.) Immunol Allergy Clin North Am. 2005 May;25(2):389-405, viii.
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Progressive exercise-induced asthma in a 38-year-old man.
(Gimenez LM, Zacharisen MC, Nordness ME.) Ann Allergy Asthma Immunol. 2003 Aug;91(2):141-7.
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5'-Peptidyl substituents allow a tuning of the affinity of oligodeoxyribonucleotides for RNA.
(Sarracino DA, Steinberg JA, Vergo MT, Woodworth GF, Tetzlaff CN, Richert C.) Bioorg Med Chem Lett. 1998 Sep 22;8(18):2511-6.
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Asthma: Comorbidities, Coexisting Conditions, and Differential Diagnosis
(Lockey RF and Ledford DK, ed..) Oxford University Press. ISBN: 9780199918065.
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A convenient synthesis of 5′-amino-5′-deoxythymidine and preparation of peptide-DNA hybrids
(Charles N. Tetzlaff, Ina Schwope, Colleen F. Bleczinski, Joshua A. Steinberg, Clemens Richert.) Tetrahedron Letters. Volume 39, Issue 24, 11 June 1998, Pages 4215–4218.