Research Programs
The research programs of the Asthma/Allergy and Clinical Immunology Division include investigations in rhinitis, asthma, hypersensitivity pneumonitis, aspergillus mediated allergic diseases, food allergy, and primary immunodeficiencies.
Current Research Studies
Pediatric and Adult Asthma Trials
- Phase IIIb Multi-center, Randomized, Double¬-Blind, Placebo-¬Controlled Study of Xolair® in Subjects with Moderate to Severe Persistent Asthma Who are Inadequately Controlled With High-Dose Inhaled Corticosteroids and Long-Acting Beta-Agonist
- Epidemiologic Study of Xolair® (Omalizumab): Evaluating Clinical Effectiveness and Long-Term Safety in Patients With Moderate to Severe Asthma (EXCELS)
- A 1 Year, Randomized, Double Blind, Parallel-Group, Placebo-Controlled, Multicenter Evaluation of Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of Omalizumab in Children (6 - <12 years) With Moderate-Severe, Persistent, Inadequately Controlled Allergic Asthma.
- Study of Acid Reflux in Children with Asthma (SARCA): The purpose of this NIH funded research is to test the hypothesis that children with symptomatic asthma will have improved asthma control with medical treatment of esophageal reflux with the proton-pump inhibitor, lansoprazole, as compared to children treated with placebo.
Food Allergy
We have ongoing clinical research projects in the area of food allergies. Current studies include:
- Detection of Peanut Protein in Serum and Saliva
- Determination Of Minimum And Non-Provoking Doses Of Soy Protein In Soy Allergic Individuals
Primary Immunodeficiency
- Pilot Program to Screen Newborns for Severe Combined Immune Deficiency (SCID) in Wisconsin: The purpose of this research is to develop a collaborative program with the WI State Department of Hygiene to screen all newborns in the State of WI for SCID. We will extract DNA from blood spots on newborn screening cards and use real time PCR to quantitate T cell receptor circles to screen for SCID.
- Lymphoproliferative Disorders in Primary Immunodeficiencies: the purpose of this research is to determine if transforming viral infections lead to lymphoproliferative disorders in patients with primary immune deficiencies.
Recent Department Publications
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A convenient synthesis of 5′-amino-5′-deoxythymidine and preparation of peptide-DNA hybrids
(Charles N. Tetzlaff, Ina Schwope, Colleen F. Bleczinski, Joshua A. Steinberg, Clemens Richert.) Tetrahedron Letters. Volume 39, Issue 24, 11 June 1998, Pages 4215–4218 08/06/1998
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All that Wheezes is not Asthma or Bronchiolitis.
(Chou EY, Pelz BJ, Chiu AM, Soung PJ.) Crit Care Clin. 2022 Apr;38(2):213-229 PMID: 35369944 SCOPUS ID: 2-s2.0-85127335877 04/05/2022
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Hereditary Angioedema: A Review.
(Zafra H.) WMJ. 2022 Apr;121(1):48-53 PMID: 35442579 SCOPUS ID: 2-s2.0-85128793938 04/21/2022
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(Wanat KA, Perelygina L, Chen MH, Hao L, Abernathy E, Bender NR, Shields BE, Wilson BD, Crosby D, Routes J, Samimi SS, Haun PL, Sokumbi O, Icenogle JP, Sullivan KE, Rosenbach M, Drolet BA.) JAMA Dermatol. 2022 Mar 26 PMID: 35338705 PMCID: PMC8957700 SCOPUS ID: 2-s2.0-85127719644 03/27/2022
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Assessment and feedback methods in competency-based medical education.
(Lee GB, Chiu AM.) Ann Allergy Asthma Immunol. 2022 03;128(3):256-262 PMID: 34929390 SCOPUS ID: 2-s2.0-85122299266 12/21/2021
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The effects of beta-lactam allergy relabeling on antibiotic prescribing practices.
(Gaberino CL, Chiu AM, Mahatme SS.) Ann Allergy Asthma Immunol. 2022 03;128(3):307-313 PMID: 34890777 SCOPUS ID: 2-s2.0-85122084422 12/11/2021
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Long-term prevention of hereditary angioedema attacks with lanadelumab: The HELP OLE Study.
(Banerji A, Bernstein JA, Johnston DT, Lumry WR, Magerl M, Maurer M, Martinez-Saguer I, Zanichelli A, Hao J, Inhaber N, Yu M, Riedl MA, HELP OLE Investigators.) Allergy. 2022 03;77(3):979-990 PMID: 34287942 SCOPUS ID: 2-s2.0-85112680925 07/22/2021
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Idiopathic Anaphylaxis: A Diagnosis of Exclusion.
(Mendez A, Pelz BJ.) Allergy Rhinol (Providence). 2021 Jan-Dec;12:21526567211041925 PMID: 34540335 PMCID: PMC8444276 09/21/2021
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(Steinberg JA.) J Allergy Clin Immunol. 2021 12;148(6):1473-1475 PMID: 34530018 SCOPUS ID: 2-s2.0-85116051600 09/17/2021
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(Nelson A, Singh A, Dasgupta M, Simpson PM, Chiu A, Brousseau DC, Panepinto JA.) J Asthma. 2021 Oct 12:1-8 PMID: 34570989 PMCID: PMC9001749 09/28/2021
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Assessment of pediatric asthma exacerbation with the use of new PROMIS measures.
(Nelson A, Ashima, Singh, Dasgupta M, Simpson PM, Chiu A, Brousseau DC, Panepinto JA.) J Asthma. 2021 10;58(10):1298-1306 PMID: 32576073 PMCID: PMC7794085 SCOPUS ID: 2-s2.0-85087818963 06/25/2020
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(Johnston DT, Busse PJ, Riedl MA, Maurer M, Anderson J, Nurse C, Inhaber N, Yu M, Banerji A, HELP Study Investigators.) Clin Exp Allergy. 2021 10;51(10):1391-1395 PMID: 34166549 SCOPUS ID: 2-s2.0-85113183008 06/25/2021
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Cephalosporin allergy symptoms in children presenting to a pediatric emergency department.
(Zembles T, Zhan Y, Chiu A, Brousseau DC, Vyles D.) Ann Allergy Asthma Immunol. 2021 08;127(2):259-260 PMID: 33940168 SCOPUS ID: 2-s2.0-85107440967 05/04/2021
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Constrained chromatin accessibility in PU.1-mutated agammaglobulinemia patients.
(Le Coz C, Nguyen DN, Su C, Nolan BE, Albrecht AV, Xhani S, Sun D, Demaree B, Pillarisetti P, Khanna C, Wright F, Chen PA, Yoon S, Stiegler AL, Maurer K, Garifallou JP, Rymaszewski A, Kroft SH, Olson TS, Seif AE, Wertheim G, Grant SFA, Vo LT, Puck JM, Sullivan KE, Routes JM, Zakharova V, Shcherbina A, Mukhina A, Rudy NL, Hurst ACE, Atkinson TP, Boggon TJ, Hakonarson H, Abate AR, Hajjar J, Nicholas SK, Lupski JR, Verbsky J, Chinn IK, Gonzalez MV, Wells AD, Marson A, Poon GMK, Romberg N.) J Exp Med. 2021 07 05;218(7) PMID: 33951726 PMCID: PMC8105723 SCOPUS ID: 2-s2.0-85105296806 05/06/2021
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(Lumry WR, Weller K, Magerl M, Banerji A, Longhurst HJ, Riedl MA, Lewis HB, Lu P, Devercelli G, Jain G, Maurer M, HELP Study Investigators.) Allergy. 2021 04;76(4):1188-1198 PMID: 33258114 PMCID: PMC8247292 SCOPUS ID: 2-s2.0-85098010100 12/02/2020
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Sustaining a nurse-led community partnership to promote environmental justice.
(Dressel A, Bell-Calvin J, Lee E, Hermanns L, Anderko L, Swaney V, Steinberg J, Hawkins M, Yeldell S.) Public Health Nurs. 2021 03;38(2):136-140 PMID: 33025643 SCOPUS ID: 2-s2.0-85092076160 10/08/2020
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(Harrison TW, Chanez P, Menzella F, Canonica GW, Louis R, Cosio BG, Lugogo NL, Mohan A, Burden A, McDermott L, Garcia Gil E, Zangrilli JG, ANDHI study investigators.) Lancet Respir Med. 2021 03;9(3):260-274 PMID: 33357499 SCOPUS ID: 2-s2.0-85099581025 12/29/2020
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(Anderson JT, Bonagura VR, Cowan J, Hsu C, Mustafa SS, Patel NC, Routes JM, Sriaroon P, Vinh DC, Hofmann JH, Praus M, Rojavin MA.) J Clin Immunol. 2021 02;41(2):458-469 PMID: 33409867 PMCID: PMC7858210 SCOPUS ID: 2-s2.0-85099072235 01/08/2021
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(Verbsky JW, Hintermeyer MK, Simpson PM, Feng M, Barbeau J, Rao N, Cool CD, Sosa-Lozano LA, Baruah D, Hammelev E, Busalacchi A, Rymaszewski A, Woodliff J, Chen S, Bausch-Jurken M, Routes JM.) J Allergy Clin Immunol. 2021 02;147(2):704-712.e17 PMID: 32745555 SCOPUS ID: 2-s2.0-85089870161 08/04/2020
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Germline IKAROS dimerization haploinsufficiency causes hematologic cytopenias and malignancies.
(Kuehn HS, Niemela JE, Stoddard J, Mannurita SC, Shahin T, Goel S, Hintermeyer M, Heredia RJ, Garofalo M, Lucas L, Singh S, Tondo A, Jacobs Z, Gahl WA, Latour S, Verbsky J, Routes J, Cunningham-Rundles C, Boztug K, Gambineri E, Fleisher TA, Chandrakasan S, Rosenzweig SD.) Blood. 2021 01 21;137(3):349-363 PMID: 32845957 PMCID: PMC7819759 SCOPUS ID: 2-s2.0-85098538966 08/28/2020
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(Anderson JT, Bonagura VR, Cowan J, Hsu C, Mustafa SS, Patel NC, Routes JM, Sriaroon P, Vinh DC, Hofmann JH, Praus M, Rojavin MA.) Journal of Clinical Immunology. February 2021;41(2):458-469 SCOPUS ID: 2-s2.0-85099072235 02/01/2021
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Granulomatous and lymphocytic interstitial lung disease diagnosed by transbronchial lung cryobiopsy.
(Doan J, Rao N, Kurman JS, Routes JM, Benn BS.) Cryobiology. 2020 12;97:231-234 PMID: 32810518 SCOPUS ID: 2-s2.0-85089727939 08/19/2020
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(Marsh RA, Leiding JW, Logan BR, Griffith LM, Arnold DE, Haddad E, Falcone EL, Yin Z, Patel K, Arbuckle E, Bleesing JJ, Sullivan KE, Heimall J, Burroughs LM, Skoda-Smith S, Chandrakasan S, Yu LC, Oshrine BR, Cuvelier GDE, Thakar MS, Chen K, Teira P, Shenoy S, Phelan R, Forbes LR, Martinez C, Chellapandian D, Dávila Saldaña BJ, Shah AJ, Weinacht KG, Joshi A, Boulad F, Quigg TC, Dvorak CC, Grossman D, Torgerson T, Graham P, Prasad V, Knutsen A, Chong H, Miller H, de la Morena MT, DeSantes K, Cowan MJ, Notarangelo LD, Kohn DB, Stenger E, Pai SY, Routes JM, Puck JM, Kapoor N, Pulsipher MA, Malech HL, Parikh S, Kang EM, submitted on behalf of the Primary Immune Deficiency Treatment Consortium.) J Clin Immunol. 2020 Nov;40(8):1211-1213 PMID: 32860171 SCOPUS ID: 2-s2.0-85089900632 08/30/2020
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Lanadelumab demonstrates rapid and sustained prevention of hereditary angioedema attacks.
(Riedl MA, Maurer M, Bernstein JA, Banerji A, Longhurst HJ, Li HH, Lu P, Hao J, Juethner S, Lumry WR, HELP Investigators.) Allergy. 2020 11;75(11):2879-2887 PMID: 32452549 PMCID: PMC7689768 SCOPUS ID: 2-s2.0-85087498118 05/27/2020
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All together to Fight COVID-19.
(Momtazmanesh S, Ochs HD, Uddin LQ, Perc M, Routes JM, Vieira DN, Al-Herz W, Baris S, Prando C, Rosivall L, Abdul Latiff AH, Ulrichs T, Roudenok V, Aldave Becerra JC, Salunke DB, Goudouris E, Condino-Neto A, Stashchak A, Kryvenko O, Stashchak M, Bondarenko A, Rezaei N.) Am J Trop Med Hyg. 2020 06;102(6):1181-1183 PMID: 32323644 PMCID: PMC7253116 SCOPUS ID: 2-s2.0-85086052683 04/24/2020
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Oral amoxicillin challenges in low-risk children during a pediatric emergency department visit.
(Vyles D, Chiu A, Routes J, Castells M, Phillips EJ, Visotcky A, Fraser R, Pezzin L, Brousseau DC.) J Allergy Clin Immunol Pract. 2020 03;8(3):1126-1128.e1 PMID: 31586667 PMCID: PMC7332348 SCOPUS ID: 2-s2.0-85073824604 10/07/2019
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Omenn Syndrome Identified by Newborn Screening
(Tallar M, Routes J.) Clinics in Perinatology. March 2020;47(1):77-86 SCOPUS ID: 2-s2.0-85076832448 03/01/2020
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Sustaining a nurse-led community partnership to promote environmental justice
(Dressel A, Bell‐Calvin J, Lee E, Hermanns L, Anderko L, Swaney V, Steinberg J, Hawkins M, Yeldell S..) Public Health Nursing. 09/19/2020
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(Steinberg JA.) Journal of Allergy and Clinical Immunology. (pending review, submitted) 05/11/2020
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When You Can't Find a Heartbeat.
(Buelow BJ, Buelow MW.) JAMA. 2019 Oct 15;322(15):1453-1454 PMID: 31613349 SCOPUS ID: 2-s2.0-85073179128 10/16/2019
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Reported Knowledge and Management of Potential Penicillin Allergy in Children.
(Vyles D, Mistry RD, Heffner V, Drayna P, Chiu A, Visotcky A, Fraser R, Brousseau DC.) Acad Pediatr. 2019 08;19(6):684-690 PMID: 30703582 SCOPUS ID: 2-s2.0-85063442775 02/01/2019
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Life-Threatening Allergies: Using a Patient-Engaged Approach.
(Gallagher JL, Rivera RD, Van Shepard K, Roushan T, Ahsan G, Ahamed SI, Chiu A, Jurken M, Simpson PM, Nugent M, Gobin KS, Wen CKF, Eldredge CE.) Telemed J E Health. 2019 04;25(4):319-325 PMID: 29969372 SCOPUS ID: 2-s2.0-85064382690 07/04/2018
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(Busse WW, Bleecker ER, FitzGerald JM, Ferguson GT, Barker P, Sproule S, Olsson RF, Martin UJ, Goldman M, BORA study investigators.) Lancet Respir Med. 2019 01;7(1):46-59 PMID: 30416083 SCOPUS ID: 2-s2.0-85056170947 11/13/2018
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Antibiotic Use After Removal of Penicillin Allergy Label.
(Vyles D, Chiu A, Routes J, Castells M, Phillips EJ, Kibicho J, Brousseau DC.) Pediatrics. 2018 05;141(5) PMID: 29678929 PMCID: PMC5914488 SCOPUS ID: 2-s2.0-85046484624 04/22/2018
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POL7085 or anti-CCL28 treatment inhibits development of post-paramyxoviral airway disease.
(Buelow BJ, Rohlfing M, Jung F, Douglas GJ, Grayson MH.) Immun Inflamm Dis. 2017 06;5(2):98-108 PMID: 28474501 PMCID: PMC5418136 SCOPUS ID: 2-s2.0-85044327542 05/06/2017
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IgE-associated food allergy alters the presentation of paediatric eosinophilic esophagitis.
(Pelz BJ, Wechsler JB, Amsden K, Johnson K, Singh AM, Wershil BK, Kagalwalla AF, Bryce PJ.) Clin Exp Allergy. 2016 11;46(11):1431-1440 PMID: 27388929 PMCID: PMC5085872 10/30/2016
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Hereditary angioedema presenting as compartment syndrome in a white girl.
(Chen WL, Gallagher J, Zafra H, Gedeit R.) Ann Allergy Asthma Immunol. 2016 Sep;117(3):321-2 PMID: 27397069 SCOPUS ID: 2-s2.0-84996565810 07/12/2016
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Newborn screening for SCID: lessons learned.
(Buelow BJ, Verbsky JW, Routes JM.) Expert Rev Hematol. 2016 Jun;9(6):579-84 PMID: 27139719 SCOPUS ID: 2-s2.0-84975263472 05/04/2016
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Pathophysiology of Food Allergy.
(Pelz BJ, Bryce PJ.) Pediatr Clin North Am. 2015 Dec;62(6):1363-75 PMID: 26456437 10/13/2015
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(Buelow BJ, Kelly BT, Zafra HT, Kelly KJ.) J Allergy Clin Immunol Pract. 2015 Jul-Aug;3(4):597-8 PMID: 25683924 SCOPUS ID: 2-s2.0-84943366931 02/17/2015
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Structure-function analysis of CCL28 in the development of post-viral asthma.
(Thomas MA, Buelow BJ, Nevins AM, Jones SE, Peterson FC, Gundry RL, Grayson MH, Volkman BF.) J Biol Chem. 2015 Feb 13;290(7):4528-36 PMID: 25556652 PMCID: PMC4326855 SCOPUS ID: 2-s2.0-84922787785 01/06/2015
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Coronin-1A: immune deficiency in humans and mice.
(Punwani D, Pelz B, Yu J, Arva NC, Schafernak K, Kondratowicz K, Makhija M, Puck JM.) J Clin Immunol. 2015 Feb;35(2):100-7 PMID: 25666293 PMCID: PMC4489527 02/11/2015
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Perception versus reality: the saga of inhaled asthma controller medication and fetal risk.
(Steinberg JA.) J Allergy Clin Immunol. 2015 Jan;135(1):131-2 PMID: 25445824 SCOPUS ID: 2-s2.0-84920603210 12/03/2014
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Newborn screening for SCID: where are we now?
(Buelow BJ, Routes JM, Verbsky JW.) Expert Rev Clin Immunol. 2014 Dec;10(12):1649-57 PMID: 25387596 SCOPUS ID: 2-s2.0-84911169687 11/13/2014
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(Miller EK, Avila PC, Khan YW, Word CR, Pelz BJ, Papadopoulos NG, Peebles RS Jr, Heymann PW, Microbes, Allergy, and Asthma Committee.) J Allergy Clin Immunol Pract. 2014 Sep-Oct;2(5):537-43 PMID: 25213046 PMCID: PMC4190166 09/13/2014
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Egg baked in product open oral food challenges are safe in selected egg-allergic patients.
(Buelow BJ, Lee C, Zafra HT, Dasgupta M, Hoffmann RG, Vasudev M.) Allergy Rhinol (Providence). 2014 Jul;5(2):110-2 PMID: 25198996 PMCID: PMC4124576 09/10/2014
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CD49d-expressing neutrophils differentiate atopic from nonatopic individuals.
(Sigua JA, Buelow B, Cheung DS, Buell E, Hunter D, Klancnik M, Grayson MH.) J Allergy Clin Immunol. 2014 Mar;133(3):901-4.e5 PMID: 24360325 SCOPUS ID: 2-s2.0-84896712652 12/24/2013
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Changes in Calcium Intake and Growth in Children With Multiple Food Allergies
(Walia CLS, Feuling MB, Baumler M, Gleason L, Tam JS, Zafra H, Goday PS.) Infant, Child, and Adolescent Nutrition. 2 December 2014;6(6):357-362 SCOPUS ID: 2-s2.0-84912129920 12/02/2014
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The value of an allergy and clinical immunology rotation at an academic tertiary medical center.
(Bauer CS, Chiu AM, Zafra HT, Gimenez LM, Nugent ML, Simpson PM, Vasudev M.) Ann Allergy Asthma Immunol. 2013 Jun;110(6):468-469.e9 PMID: 23706721 SCOPUS ID: 2-s2.0-84878216059 05/28/2013
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Vocal cord dysfunction: an update.
(Gimenez LM, Zafra H.) Ann Allergy Asthma Immunol. 2011 Apr;106(4):267-74; quiz 275 PMID: 21457874 SCOPUS ID: 2-s2.0-79953305644 04/05/2011
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Absence of mycobacterium avium subsp. paratuberculosis in Crohn's patients.
(Parrish NM, Radcliff RP, Brey BJ, Anderson JL, Clark DL Jr, Koziczkowski JJ, Ko CG, Goldberg ND, Brinker DA, Carlson RA, Dick JD, Ellingson JL.) Inflamm Bowel Dis. 2009 Apr;15(4):558-65 PMID: 19058231 12/06/2008
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Adverse reactions to orthodontic appliances in nickel-allergic patients.
(Volkman KK, Inda MJ, Reichl PG, Zacharisen MC.) Allergy Asthma Proc. 2007 Jul-Aug;28(4):480-4 PMID: 17883919 SCOPUS ID: 2-s2.0-34548610281 09/22/2007
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Yacht-maker's lung: A case of hypersensitivity pneumonitis in yacht manufacturing.
(Volkman KK, Merrick JG, Zacharisen MC.) WMJ. 2006 Oct;105(7):47-50 PMID: 17163087 SCOPUS ID: 2-s2.0-33750825075 12/14/2006
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(Brey BJ, Radcliff RP, Clark DL Jr, Ellingson JL.) Mol Cell Probes. 2006 Feb;20(1):51-9 PMID: 16337359 12/13/2005
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Progressive exercise-induced asthma in a 38-year-old man.
(Gimenez LM, Zacharisen MC, Nordness ME.) Ann Allergy Asthma Immunol. 2003 Aug;91(2):141-7 PMID: 12952107 09/04/2003
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5'-Peptidyl substituents allow a tuning of the affinity of oligodeoxyribonucleotides for RNA.
(Sarracino DA, Steinberg JA, Vergo MT, Woodworth GF, Tetzlaff CN, Richert C.) Bioorg Med Chem Lett. 1998 Sep 22;8(18):2511-6 PMID: 9873571 SCOPUS ID: 2-s2.0-0032558529 01/05/1999
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A convenient synthesis of 5'-amino-5'-deoxythymidine and preparation of peptide-DNA hybrids
(Tetzlaff CN, Schwope I, Bleczinski CF, Steinberg JA, Richert C.) Tetrahedron Letters. 11 June 1998;39(24):4215-4218 SCOPUS ID: 2-s2.0-0032508016 06/11/1998
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(Erin Lee, Anne Dressel, Jean Bell-Calvin, Zhuping Garacci, Joshua Steinberg.) Journal of Allergy and Clinical Immunology. https://doi.org/10.1016/j.jaci.2019.12.684 02/01/2020
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Asthma: Comorbidities, Coexisting Conditions, and Differential Diagnosis
(Lockey RF and Ledford DK, ed..) Oxford University Press. ISBN: 9780199918065 02/21/2014