Pharmacology and Toxicology

Welcome to the Department of Pharmacology and Toxicology at the Medical College of Wisconsin is dedicated to quality in research, graduate and postdoctoral training and medical education. The research interests of our faculty are broadly based in cardiovascular pharmacology, neuropharmacology, cancer pharmacology, toxicology and molecular pharmacology. The research programs in the Department of Pharmacology and Toxicology are also multidisciplinary in nature and have strong associations with researchers of other basic science and clinical departments. Read more about Pharmacology and Toxicology

John D. Imig, PhD

John D. Imig, PhD

Professor, Pharmacology and Toxicology

Can a research laboratory make major breakthroughs and develop novel therapeutics for cardiovascular and kidney diseases? The answer is a resounding, YES!

Dr. Imig’s research has focused on a class of fatty acids, arachidonic acid metabolites that have been targeted by drugs for the treatment of pain, fever, blood clotting, and asthma. Utilizing animal models of cardiovascular and kidney diseases his laboratory has demonstrated that arachidonic acid metabolites called epoxyeicosatrienoic acids (EETs) and the enzyme soluble epoxide hydrolase are not properly regulated during disease states. Over the past decade his laboratory was a major driving force in the development of drugs that inhibit the soluble epoxide hydrolase enzyme and one of these drugs is currently being tested in humans for the treatment of chronic obstructive pulmonary disease (COPD). More recently, the laboratory has focused on developing EET-based drugs for the treatment of hypertension, acute renal failure, and chronic kidney disease. These novel small molecule EET analogs are demonstrating great potential and could one day in the near future be used to treat cardiovascular and kidney diseases in humans.

Earn a graduate degree from Pharmacology and Toxicology

Our graduate degree program includes dynamically changing disciplines such as neuropharmacology and molecular pharmacology. This program receives many students from the Interdisciplinary Program of Neuroscience and Biomedical Science. Learn more

Career Opportunities

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  MCW Presidential Postdoctoral Scholar

Position Purpose

Perform intravital multiphoton imaging for neuroscience studies. The project will use in vivo multiphoton imaging and activity-dependent reporters to investigate neural ensembles engaged by drug and non-drug motivated behavior.

The successful candidate will have published proficiency in intravital imaging and motivation to develop techniques to image superficial and subcortical structures. Candidates should have strong communication skills, a record of scientific productivity, and a desire to work both independently and as part of a team.

The Neuroscience Research Center is home to over 100 neuroscientists and the Medical College of Wisconsin has numerous core facilities and other resources to promote scientific training and multidisciplinary research.

 

Essential Duties

  1. Develop and conduct experiments to study neural ensembles in mesocorticolimbic circuitry engaged by self-administration of drugs of abuse and/or non-drug rewards. Develop protocols to enable long-term studies involving repeated in vivo multiphoton imaging.
     
  2. Perform experiments under the direction of the Principle Investigator, including other studies involving drug and non-drug motivated behaviors.
     
  3. Develop and conduct laboratory procedures including timely data analysis and archiving of data obtained in one or more areas of laboratory investigation.
     
  4. Adapt to general laboratory procedures to accomplish specific experimental goals of the laboratory, working closely in team setting with other members of the lab team.
     
  5. Participate in meetings with PI and other laboratory personnel to discuss and evaluate research being undertaken and in progress.
     
  6. Perform surgical procedures and behavioral experiments.

Other Duties

Perform other duties as assigned. Some experiments may require work on the weekends, although this is not routine.

Qualifications | Minimum Position Qualifications

Required background: PhD in Neuroscience, Cell Biology, Engineering or other relevant field. Experience with intravital imaging.

Contact Us

Pharmacology and Toxicology
Medical College of Wisconsin
8701 Watertown Plank Road
Milwaukee, WI 53226-0509

(414) 955-8267 | (414) 955-6545 (fax)

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