Caitlin O'Meara, PhD

Assistant Professor

Locations

Cardiovascular Center

Contact Information

Education

PhD, Medical College of Wisconsin, 2011
Postdoctoral Training, Harvard Medical School, 2016

Research Interests

Higher organisms such as zebrafish and neonatal mice are capable of complete heart regeneration following partial amputation. Although adult humans and adult mice lack this regeneration response, there is great interest in understanding how heart regeneration can occur in lower organisms so that we can activate this process in humans to better treat patients following myocardial infarction. My lab is interested in understanding the cell biology and molecular pathways that facilitate heart regeneration and cardiomyocyte cell cycle activity. Factors that we find to mediate cardiac regeneration in zebrafish or neonatal mice are then tested in adult non-regenerative mammalian models to identify potential therapeutic targets for promoting cardiac healing.

Reperfused vs. nonreperfused myocardial infarction: when to use which model.

(Lindsey ML, de Castro Brás LE, DeLeon-Pennell KY, Frangogiannis NG, Halade GV, O'Meara CC, Spinale FG, Kassiri Z, Kirk JA, Kleinbongard P, Ripplinger CM, Brunt KR.) Am J Physiol Heart Circ Physiol. 2021 07 01;321(1):H208-H213 PMID: 34114891 PMCID: PMC8321810 06/12/2021
Llgl1 regulates zebrafish cardiac development by mediating Yap stability in cardiomyocytes.

(Flinn MA, Otten C, Brandt ZJ, Bostrom JR, Kenarsary A, Wan TC, Auchampach JA, Abdelilah-Seyfried S, O'Meara CC, Link BA.) Development. 2020 08 25;147(16) PMID: 32843528 PMCID: PMC7473637 SCOPUS ID: 2-s2.0-85089923843 08/28/2020
Upstream regulation of the Hippo-Yap pathway in cardiomyocyte regeneration.

(Flinn MA, Link BA, O'Meara CC.) Semin Cell Dev Biol. 2020 04;100:11-19 PMID: 31606277 PMCID: PMC7263368 SCOPUS ID: 2-s2.0-85073003673 10/14/2019
Steps toward therapeutically targeting the activin type II receptor for treating heart failure.

(Paddock SJ, O'Meara CC.) Am J Physiol Heart Circ Physiol. 2020 02 01;318(2):H326-H328 PMID: 31922889 PMCID: PMC7052619 01/11/2020
Yap is required for scar formation but not myocyte proliferation during heart regeneration in zebrafish.

(Flinn MA, Jeffery BE, O'Meara CC, Link BA.) Cardiovasc Res. 2019 03 01;115(3):570-577 PMID: 30295714 SCOPUS ID: 2-s2.0-85061983162 10/09/2018
IL-13 promotes in vivo neonatal cardiomyocyte cell cycle activity and heart regeneration.

(Wodsedalek DJ, Paddock SJ, Wan TC, Auchampach JA, Kenarsary A, Tsaih SW, Flister MJ, O'Meara CC.) Am J Physiol Heart Circ Physiol. 2019 01 01;316(1):H24-H34 PMID: 30339498 SCOPUS ID: 2-s2.0-85060194313 10/20/2018
Soluble interleukin-13rα1: a circulating regulator of glucose.

(Rachmin I, O'Meara CC, Ricci-Blair EM, Feng Y, Christensen EM, Duffy JF, Zitting KM, Czeisler CA, Pancoast JR, Cannon CP, O'Donoghue ML, Morrow DA, Lee RT.) Am J Physiol Endocrinol Metab. 2017 12 01;313(6):E663-E671 PMID: 28874358 PMCID: PMC5814599 09/07/2017
Nerves Regulate Cardiomyocyte Proliferation and Heart Regeneration.

(Mahmoud AI, O'Meara CC, Gemberling M, Zhao L, Bryant DM, Zheng R, Gannon JB, Cai L, Choi WY, Egnaczyk GF, Burns CE, Burns CG, MacRae CA, Poss KD, Lee RT.) Dev Cell. 2015 Aug 24;34(4):387-99 PMID: 26256209 PMCID: PMC4550513 08/11/2015
Peering Into the Cardiomyocyte Nuclear Epigenetic State.

(O'Meara CC, Lee RT.) Circ Res. 2015 Aug 14;117(5):392-4 PMID: 26271534 PMCID: PMC4538702 08/15/2015
Cardiac myosin binding protein C regulates postnatal myocyte cytokinesis.

(Jiang J, Burgon PG, Wakimoto H, Onoue K, Gorham JM, O'Meara CC, Fomovsky G, McConnell BK, Lee RT, Seidman JG, Seidman CE.) Proc Natl Acad Sci U S A. 2015 Jul 21;112(29):9046-51 PMID: 26153423 PMCID: PMC4517252 07/15/2015
Response to Comment to the article 'A systematic analysis of neonatal mouse heart regeneration after apical resection'.

(Bryant DM, O'Meara CC, Ho NN, Gannon J, Cai L, Lee RT.) J Mol Cell Cardiol. 2015 May;82:184-5 PMID: 25771145 03/17/2015
SH2B3 Is a Genetic Determinant of Cardiac Inflammation and Fibrosis.

(Flister MJ, Hoffman MJ, Lemke A, Prisco SZ, Rudemiller N, O'Meara CC, Tsaih SW, Moreno C, Geurts AM, Lazar J, Adhikari N, Hall JL, Jacob HJ.) Circ Cardiovasc Genet. 2015 Apr;8(2):294-304 PMID: 25628389 SCOPUS ID: 2-s2.0-84942919523 01/30/2015

O'Meara Lab Staff

Santiago Alvarez, MD

Graduate Student

salvarez@mcw.edu

My research interest focuses on cardiac recovering, tissue remodeling and heart failure development after acute cardiac injury, looking particularly at the role of interleukin 4 and 13 in cardiac macrophages in promoting cardiac regeneration and improving outcome.