Medical College of Wisconsin
Medical College of Wisconsin Medical College of Wisconsin
Visitors, including guests, contractors and vendors, to any MCW campus are asked to refrain from coming to campus. Badge-access is required to enter any campus building. All MCW-sponsored site visits or gatherings of more than 10 individuals are cancelled and/or must be rescheduled for a later date. For MCW updates on the COVID-19 pandemic, visit covid19.mcw.edu.
Staff Collaborate Conference Room

Candice S. Klug, PhD

Candice Klug

Candice S. Klug, PhD

Professor; Director, National Biomedical EPR Center; Program Director, Biophysics Graduate Program

Locations

  • Biophysics
    MFRC 2026

Contact Information

Education

Postdoctoral Fellow in Ophthalmic Biophysical Chemistry, UCLA School of Medicine, Jules Stein Eye Institute, Los Angeles, CA, 1999-2001
PhD, Biophysics, Medical College of Wisconsin, Milwaukee, WI, 1999
BS, Chemistry, Massachusetts Institute of Technology, Cambridge, MA, 1994

Biography

My research interests currently focus on protein structure and dynamics. I use the site-directed spin labeling (SDSL) EPR spectroscopy technique to study the functional dynamics of soluble and membrane proteins essential to bacterial viability.

Methodologies and Techniques

  • Adenosine Triphosphatases
  • Amino Acid Motifs
  • ArnT
  • Arrestin
  • Arrestins
  • ATP-Binding Cassette Transporters
  • Bacterial Proteins
  • electron paramagnetic resonance spectroscopy
  • Electron Spin Resonance Spectroscopy
  • Escherichia coli Proteins
  • Lipid A
  • Lipopolysaccharides

Leadership Positions

  • Associate Director, National Biomedical EPR Center, 2014-2016
  • Chair, Graduate School Curriculum and Programs Committee, 2010-2013
  • Chair, Women in Science Advisory Committee, 2011 - 2016
  • Chair, Women's Faculty Council, 2006-2007
  • Director, National Biomedical EPR Center, 2016 - present
  • President, MCW Faculty Council, 2016-2017
  • Program Director, Biophysics Graduate Program, 2013 - present
  • Training Program Director, National Biomedical EPR Center, 2003-present

MCW Program / Core Facilities

  • Biophysics Graduate Program
  • Interdisciplinary Program in the Biomedical Sciences
  • National Biomedical EPR Center

Research Interests

LptA-Mediated Transport of LPS is an R01 award from the National Institute of General Medical Sciences to study how LptA transports LPS. Genetic screenings, laser light scattering analyses, EPR spectroscopy studies, and isothermal titration calorimetry measurements are used to provide detailed insights into the mechanisms of LPS transport across the periplasm of Gram-negative bacteria.

National Biomedical EPR Center is a P41 award from the National Institute of Biomedical Imaging and Bioengineering. The mission of the EPR Center is to serve the community of EPR spectroscopists by development of advanced EPR instrumentation and new EPR methodology.

Lab Members
Malory Mueller, Research Technologist I
Kathryn Schultz, Research Scientist I

Publications

Publications of Candice S. Klug PhD from the Faculty Collaboration Database