Shi-Jiang Li, PhD |Professor | Medical College of Wisconsin

Shi-Jiang Li, PhD

Professor

Locations

Biophysics
MFRC 2040A

Contact Information

Biography

After receiving my engineering degree from Tsinghua University, I worked for eight years as a communication engineer and later as a graduate student in the Biophysics Research Institute, Chinese Academy of Science. My multidisciplinary education and experiences have provided me with a broad background to conduct sophisticated biophysics research.

Education

Postdoctoral in MRI/MRS, John Hopkins School of Medicine, Baltimore, MD, 1988-1991
PhD, Biochemistry, Ohio State University, Columbus, OH, 1985
MS program, Biophysics, Biophysics Research Institute, Chinese Academy of Science, Beijing, China, 1980
BS, Electronics, Tsinghua University, Beijing, China, 1970

Research Interests

My research focuses on improving and developing advanced MRI acquisition and data analysis techniques to measure brain functional and structural network organizations.

Research Projects
I have the following NIH-funded research projects:

Alzheimer's Disease Connectome Project
NIH/NIA (MPI study with Barbara Bendlin, University of Wisconsin-Madison)
The long-term goal of this project is to apply the Human Connectome Project data collection protocol and develop robust technology to accurately stage Alzheimer's disease across the full spectrum of its progression on an individual subject basis. Interested in participating?
Network-Level Mechanisms for Preclinical Alzheimer’s Disease Development
NIH/NIA
The overall goal of this project is to examine the neural-network-damaging processes during AD progression to yield insights into the APOE–Age–AD relationships by mathematically modeling the Age–AD two-dimensional space.

Lab Members
Gang Chen, PhD, Research Scientist II
Guangyu Chen, PhD, Research Scientist

Collaborators
Piero G. Antuono, MD, Professor, Neurology, Pharmacology, and Toxicology, MCW
Arash Babaei, MD, Assistant Professor, Gastroenterology and Hepatology, MCW
Malgorzata B. Franczak, MD, Professor, Neurology, MCW
Joseph Goveas, MD, Associate Professor, Psychiatry and Behavioral Medicine, MCW
Anthony Hudetz, PhD, Professor, Anesthesiology, University of Michigan
Kathryn K. Lauer, MD, Professor, Anesthesiology, MCW
Xiaolin Liu, PhD, Assistant Professor, Radiology, MCW
Yang Wang, MD, PhD, Associate Professor, Radiology, MCW
B. Doug Ward, Senior Statistician, Biophysics, MCW

Disrupted Interactions Between Arousal and Cortical Awareness Networks in MCS and VS/UWS Patients: Evidence from Resting-state Functional Imaging Connectivity.

(Chen S, Wu X, Wang L, Wang Y, Wu B, Ge M, Xu Z, Ward BD, Li SJ, Liu X, Yang Z.) Neuroscience. 2018 Jul 01;382:115-124.
Regional entropy of functional imaging signals varies differently in sensory and cognitive systems during propofol-modulated loss and return of behavioral responsiveness.

(Liu X, Lauer KK, Ward BD, Roberts CJ, Liu S, Gollapudy S, Rohloff R, Gross W, Xu Z, Chen S, Wang L, Yang Z, Li SJ, Binder JR, Hudetz AG.) Brain Imaging Behav. 2018 May 08.
Distinct neural correlates of episodic memory among apolipoprotein E alleles in cognitively normal elderly.

(Shu H, Shi Y, Chen G, Wang Z, Liu D, Yue C, Ward BD, Li W, Xu Z, Chen G, Guo QH, Xu J, Li SJ, Zhang Z.) Brain Imaging Behav. 2018 Feb 02.
Reduced Functional Connectivity Between the Hypothalamus and High-order Cortical Regions in Adolescent Patients With Irritable Bowel Syndrome.

(Liu X, Li SJ, Shaker R, Silverman A, Kern M, Ward DB, Li W, Xu Z, Chelimsky G, Sood MR.) J Pediatr Gastroenterol Nutr. 2017 Nov;65(5):516-519.
Large-Scale Network Analysis of Whole-Brain Resting-State Functional Connectivity in Spinal Cord Injury: A Comparative Study.

(Kaushal M, Oni-Orisan A, Chen G, Li W, Leschke J, Ward D, Kalinosky B, Budde M, Schmit B, Li SJ, Muqeet V, Kurpad S.) Brain Connect. 2017 09;7(7):413-423.
The Effect of Apolipoprotein E ε4 (APOE ε4) on Visuospatial Working Memory in Healthy Elderly and Amnestic Mild Cognitive Impairment Patients: An Event-Related Potentials Study.

(Gu LH, Chen J, Gao LJ, Shu H, Wang Z, Liu D, Yan YN, Li SJ, Zhang ZJ.) Front Aging Neurosci. 2017;9:145.
Fine-Grained Parcellation of Brain Connectivity Improves Differentiation of States of Consciousness During Graded Propofol Sedation.

(Liu X, Lauer KK, Ward BD, Roberts CJ, Liu S, Gollapudy S, Rohloff R, Gross W, Xu Z, Chen G, Binder JR, Li SJ, Hudetz AG.) Brain Connect. 2017 08;7(6):373-381.
Intrinsic inter-network brain dysfunction correlates with symptom dimensions in late-life depression.

(Li W, Wang Y, Ward BD, Antuono PG, Li SJ, Goveas JS.) J Psychiatr Res. 2017 04;87:71-80.
Propofol attenuates low-frequency fluctuations of resting-state fMRI BOLD signal in the anterior frontal cortex upon loss of consciousness.

(Liu X, Lauer KK, Douglas Ward B, Roberts C, Liu S, Gollapudy S, Rohloff R, Gross W, Chen G, Xu Z, Binder JR, Li SJ, Hudetz AG.) Neuroimage. 2017 02 15;147:295-301.
Evaluation of Whole-Brain Resting-State Functional Connectivity in Spinal Cord Injury: A Large-Scale Network Analysis Using Network-Based Statistic.

(Kaushal M, Oni-Orisan A, Chen G, Li W, Leschke J, Ward BD, Kalinosky B, Budde MD, Schmit BD, Li SJ, Muqeet V, Kurpad SN.) J Neurotrauma. 2017 Mar 15;34(6):1278-1282.
Staging Alzheimer's Disease Risk by Sequencing Brain Function and Structure, Cerebrospinal Fluid, and Cognition Biomarkers.

(Chen G, Shu H, Chen G, Ward BD, Antuono PG, Zhang Z, Li SJ, Alzheimer’s Disease Neuroimaging Initiative.) J Alzheimers Dis. 2016 10 04;54(3):983-993.
Alterations in Cortical Sensorimotor Connectivity following Complete Cervical Spinal Cord Injury: A Prospective Resting-State fMRI Study.

(Oni-Orisan A, Kaushal M, Li W, Leschke J, Ward BD, Vedantam A, Kalinosky B, Budde MD, Schmit BD, Li SJ, Muqeet V, Kurpad SN.) PLoS One. 2016;11(3):e0150351.