Yiliang Chen, PhD
- Versiti Blood Research Institute,
MS, National University of Singapore, Singapore, 2004
BS, Fudan University, China, 2001
Dr. Chen received his Bachelor of Science degree in Genetics from Fudan University (China) in 2001 and his Doctorate degree from the University of Toledo (USA) in 2009, where he studied cholesterol metabolisms and signal transduction. He pursued his postdoctoral work at Blood Center of Wisconsin, Blood Research Institute, where he worked on the functions of a scavenger receptor CD36 and its role in chronic inflammation and atherosclerosis. Dr. Chen joined the MCW faculty in 2020 as an Assistant Professor in the Department of Medicine. He is also a member of MCW’s Cardiovascular Center. Dr. Chen has a life-long passion in the study of metabolic diseases that are often associated with oxidative stress, abnormal lipid metabolism and chronic inflammation.
Honors and Awards
2012 Travel Award for Young Investigators
2008 Retiree’s Scholarship Award Winner, University of Toledo
2004-2009 Pre-Doctoral Fellowship, University of Toledo
2002-2004 Research Fellowship, National University of Singapore, Singapore
We are interested in a chronic inflammatory disease called atherosclerosis, which is the leading cause of death in the developed countries. Atherosclerosis is characterized by atherosclerotic plaques in the medium and large arteries and the major components of the plaques are lipid-laden innate immune cells called macrophages. Using a variety of genetically modified mice as in vivo animal models together with in vitro cell culture model and many biochemical techniques, we study the molecular mechanisms underlying the pro-atherogenic functions of the macrophages.
We are also using novel state-of-the-art technologies including single cell RNA sequencing, high resolution confocal microscopy, Seahorse extracellular flux metabolic assays, GC-MS, and so on to explore cell expression network that are linked to immune activation and metabolic status. With these novel tools, we are able to study not only the macrophage functions but also the cross talk between macrophage and other cell types.
- How CD36-mediated signaling and the fatty acid trafficking influence macrophage immune activation?
- How does mitochondria integrate lipid signals and other metabolic signals to determine its function (e.g. oxidative phosphorylation vs. ROS production)?
- How does macrophage communicate with adipocytes under atherogenic conditions, which facilitate chronic inflammation?
(Khalaf FK, Tassavvor I, Mohamed A, Chen Y, Malhotra D, Xie Z, Tian J, Haller ST, Westfall K, Tang WHW, Kennedy DJ.) J Am Heart Assoc. 2020 02 04;9(3):e013933 PMID: 32013704 PMCID: PMC7033897 SCOPUS ID: 2-s2.0-85078888113 02/06/2020
(Schill RL, Knaack DA, Powers HR, Chen Y, Yang M, Schill DJ, Silverstein RL, Sahoo D.) FEBS J. 2020 02;287(4):695-707 PMID: 31386799 PMCID: PMC7002295 SCOPUS ID: 2-s2.0-85070750063 08/07/2019
(Chen Y, Yang M, Huang W, Chen W, Zhao Y, Schulte ML, Volberding P, Gerbec Z, Zimmermann MT, Zeighami A, Demos W, Zhang J, Knaack DA, Smith BC, Cui W, Malarkannan S, Sodhi K, Shapiro JI, Xie Z, Sahoo D, Silverstein RL.) Circ Res. 2019 12 06;125(12):1087-1102 PMID: 31625810 PMCID: PMC6921463 SCOPUS ID: 2-s2.0-85076330129 10/19/2019
(Chen Y, Silverstein RL.) Blood. 2018 09 13;132(11):1089-1091 PMID: 30213838 SCOPUS ID: 2-s2.0-85053125219 09/15/2018
(Chen Y, Huang W, Yang M, Xin G, Cui W, Xie Z, Silverstein RL.) Arterioscler Thromb Vasc Biol. 2017 08;37(8):1462-1469 PMID: 28619997 PMCID: PMC5532064 SCOPUS ID: 2-s2.0-85020518621 06/18/2017
(Yang M, Cooley BC, Li W, Chen Y, Vasquez-Vivar J, Scoggins NO, Cameron SJ, Morrell CN, Silverstein RL.) Blood. 2017 05 25;129(21):2917-2927 PMID: 28336528 PMCID: PMC5445574 SCOPUS ID: 2-s2.0-85019661296 03/25/2017
(Dong L, Yuan Y, Opansky C, Chen Y, Aguilera-Barrantes I, Wu S, Yuan R, Cao Q, Cheng YC, Sahoo D, Silverstein RL, Ren B.) Oncotarget. 2017 Apr 04;8(14):22550-22562 PMID: 28186980 PMCID: PMC5410244 SCOPUS ID: 2-s2.0-85016933174 02/12/2017
(Ramakrishnan DP, Hajj-Ali RA, Chen Y, Silverstein RL.) Arterioscler Thromb Vasc Biol. 2016 Mar;36(3):534-44 PMID: 26821945 PMCID: PMC4767682 SCOPUS ID: 2-s2.0-84959464380 01/30/2016
(Chen Y, Kennedy DJ, Ramakrishnan DP, Yang M, Huang W, Li Z, Xie Z, Chadwick AC, Sahoo D, Silverstein RL.) Sci Signal. 2015 Sep 08;8(393):ra91 PMID: 26350901 PMCID: PMC4852751 SCOPUS ID: 2-s2.0-84941034207 09/10/2015
(Chadwick AC, Holme RL, Chen Y, Thomas MJ, Sorci-Thomas MG, Silverstein RL, Pritchard KA Jr, Sahoo D.) PLoS One. 2015;10(4):e0123138 PMID: 25849485 PMCID: PMC4388475 SCOPUS ID: 2-s2.0-84927672521 04/08/2015
(Chen Y, Ramakrishnan DP, Ren B.) Front Biosci (Landmark Ed). 2013 Jun 01;18:852-61 PMID: 23747852 SCOPUS ID: 2-s2.0-84880398679 06/12/2013
(Kennedy DJ, Chen Y, Huang W, Viterna J, Liu J, Westfall K, Tian J, Bartlett DJ, Tang WH, Xie Z, Shapiro JI, Silverstein RL.) Hypertension. 2013 Jan;61(1):216-24 PMID: 23172921 PMCID: PMC3521864 SCOPUS ID: 2-s2.0-84871620197 11/23/2012