Yiliang Chen Laboratory
Location
Versiti Blood Research Institute
Room 235
General Interests
Metabolism, Immunology
View Yiliang Chen, PhD BioResearch Areas
Project 1: Study of CD36 and its signaling partners such as Na/K-ATPase in signal transduction for macrophage activation
Project 2: Study of fatty acid trafficking and regulation that is coupled with mitochondria functions
Project 3: Study of mitochondrial ROS production and their influence in efferocytosis
Project 4: Study of CD36/Pim1 pathway in foam cell formation and development of atherosclerosis
Current Members

Jue Zhang, PhD
Postdoctoral Fellow
Recent Publications
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Na/K-ATPase suppresses LPS-induced pro-inflammatory signaling through Lyn.
(Zhang J, Chang J, Beg MA, Huang W, Zhao Y, Dai W, Wu X, Cui W, Pillai SS, Lakhani HV, Sodhi K, Shapiro JI, Sahoo D, Zheng Z, Silverstein RL, Chen Y.) iScience. 2022 Sep 16;25(9):104963 PMID: 36072548 PMCID: PMC9442361 SCOPUS ID: 2-s2.0-85137074779 09/09/2022
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(Palma FR, Ratti BA, Paviani V, Coelho DR, Miguel R, Danes JM, Zaichik SV, de Abreu AL, Silva SO, Chen Y, Silverstein RL, Karan U, Jones DP, Bonini MG.) Oncogene. 2021 Sep;40(36):5455-5467 PMID: 34290400 PMCID: PMC8669831 SCOPUS ID: 2-s2.0-85110982210 07/23/2021
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(Hou Y, Wang Q, Han B, Chen Y, Qiao X, Wang L.) Cell Death Dis. 2021 May 21;12(6):523 PMID: 34021126 PMCID: PMC8140121 SCOPUS ID: 2-s2.0-85106615244 05/23/2021
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Targeting PIM1-Mediated Metabolism in Myeloid Suppressor Cells to Treat Cancer.
(Xin G, Chen Y, Topchyan P, Kasmani MY, Burns R, Volberding PJ, Wu X, Cohn A, Chen Y, Lin CW, Ho PC, Silverstein R, Dwinell MB, Cui W.) Cancer Immunol Res. 2021 Apr;9(4):454-469 PMID: 33579728 PMCID: PMC8137571 SCOPUS ID: 2-s2.0-85104420312 02/14/2021
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(Zhang J, Li X, Yu H, Larre I, Dube PR, Kennedy DJ, Tang WHW, Westfall K, Pierre SV, Xie Z, Chen Y.) Am J Physiol Cell Physiol. 2020 Dec 01;319(6):C1107-C1119 PMID: 32997514 PMCID: PMC7792677 SCOPUS ID: 2-s2.0-85098226317 10/01/2020
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(Wang X, Cai L, Xie JX, Cui X, Zhang J, Wang J, Chen Y, Larre I, Shapiro JI, Pierre SV, Wu D, Zhu GZ, Xie Z.) Sci Adv. 2020 May;6(22):eaaw5851 PMID: 32537485 PMCID: PMC7253156 SCOPUS ID: 2-s2.0-85086625763 06/17/2020
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(Khalaf FK, Tassavvor I, Mohamed A, Chen Y, Malhotra D, Xie Z, Tian J, Haller ST, Westfall K, Tang WHW, Kennedy DJ.) J Am Heart Assoc. 2020 Feb 04;9(3):e013933 PMID: 32013704 PMCID: PMC7033897 SCOPUS ID: 2-s2.0-85078888113 02/06/2020
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(Schill RL, Knaack DA, Powers HR, Chen Y, Yang M, Schill DJ, Silverstein RL, Sahoo D.) FEBS J. 2020 Feb;287(4):695-707 PMID: 31386799 PMCID: PMC7002295 SCOPUS ID: 2-s2.0-85070750063 08/07/2019
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Mitochondrial Metabolic Reprogramming by CD36 Signaling Drives Macrophage Inflammatory Responses.
(Chen Y, Yang M, Huang W, Chen W, Zhao Y, Schulte ML, Volberding P, Gerbec Z, Zimmermann MT, Zeighami A, Demos W, Zhang J, Knaack DA, Smith BC, Cui W, Malarkannan S, Sodhi K, Shapiro JI, Xie Z, Sahoo D, Silverstein RL.) Circ Res. 2019 Dec 06;125(12):1087-1102 PMID: 31625810 PMCID: PMC6921463 SCOPUS ID: 2-s2.0-85076330129 10/19/2019
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Platelet metabolism meets thrombosis.
(Chen Y, Silverstein RL.) Blood. 2018 Sep 13;132(11):1089-1091 PMID: 30213838 SCOPUS ID: 2-s2.0-85053125219 09/15/2018
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(Chen Y, Huang W, Yang M, Xin G, Cui W, Xie Z, Silverstein RL.) Arterioscler Thromb Vasc Biol. 2017 Aug;37(8):1462-1469 PMID: 28619997 PMCID: PMC5532064 SCOPUS ID: 2-s2.0-85020518621 06/18/2017
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Platelet CD36 promotes thrombosis by activating redox sensor ERK5 in hyperlipidemic conditions.
(Yang M, Cooley BC, Li W, Chen Y, Vasquez-Vivar J, Scoggins NO, Cameron SJ, Morrell CN, Silverstein RL.) Blood. 2017 May 25;129(21):2917-2927 PMID: 28336528 PMCID: PMC5445574 SCOPUS ID: 2-s2.0-85019661296 03/25/2017