Endocrinology and Molecular Medicine

Recent Publications

• Targeting PIM1-Mediated Metabolism in Myeloid Suppressor Cells to Treat Cancer.

  (Xin G, Chen Y, Topchyan P, Kasmani MY, Burns R, Volberding PJ, Wu X, Cohn A, Chen Y, Lin CW, Ho PC, Silverstein R, Dwinell MB, Cui W.) Cancer Immunol Res. 2021 Feb 12 PMID: 33579728 02/14/2021

• Regulation of Na/K-ATPase expression by cholesterol: isoform specificity and the molecular mechanism.

  (Zhang J, Li X, Yu H, Larre I, Dube PR, Kennedy DJ, Tang WHW, Westfall K, Pierre SV, Xie Z, Chen Y.) Am J Physiol Cell Physiol. 2020 12 01;319(6):C1107-C1119 PMID: 32997514 PMCID: PMC7792677 SCOPUS ID: 2-s2.0-85098226317 10/01/2020

• A caveolin binding motif in Na/K-ATPase is required for stem cell differentiation and organogenesis in mammals and C.elegans.

  (Wang X, Cai L, Xie JX, Cui X, Zhang J, Wang J, Chen Y, Larre I, Shapiro JI, Pierre SV, Wu D, Zhu GZ, Xie Z.) Sci Adv. 2020 May;6(22):eaaw5851 PMID: 32537485 PMCID: PMC7253156 SCOPUS ID: 2-s2.0-85086625763 06/17/2020

• Epithelial and Endothelial Adhesion of Immune Cells Is Enhanced by Cardiotonic Steroid Signaling Through Na+/K+-ATPase-α-1.

  (Khalaf FK, Tassavvor I, Mohamed A, Chen Y, Malhotra D, Xie Z, Tian J, Haller ST, Westfall K, Tang WHW, Kennedy DJ.) J Am Heart Assoc. 2020 02 04;9(3):e013933 PMID: 32013704 PMCID: PMC7033897 SCOPUS ID: 2-s2.0-85078888113 02/06/2020

• Modification of HDL by reactive aldehydes alters select cardioprotective functions of HDL in macrophages.

  (Schill RL, Knaack DA, Powers HR, Chen Y, Yang M, Schill DJ, Silverstein RL, Sahoo D.) FEBS J. 2020 02;287(4):695-707 PMID: 31386799 PMCID: PMC7002295 SCOPUS ID: 2-s2.0-85070750063 08/07/2019

• Mitochondrial Metabolic Reprogramming by CD36 Signaling Drives Macrophage Inflammatory Responses.

  (Chen Y, Yang M, Huang W, Chen W, Zhao Y, Schulte ML, Volberding P, Gerbec Z, Zimmermann MT, Zeighami A, Demos W, Zhang J, Knaack DA, Smith BC, Cui W, Malarkannan S, Sodhi K, Shapiro JI, Xie Z, Sahoo D, Silverstein RL.) Circ Res. 2019 12 06;125(12):1087-1102 PMID: 31625810 PMCID: PMC6921463 SCOPUS ID: 2-s2.0-85076330129 10/19/2019

• Platelet metabolism meets thrombosis.

  (Chen Y, Silverstein RL.) Blood. 2018 09 13;132(11):1089-1091 PMID: 30213838 SCOPUS ID: 2-s2.0-85053125219 09/15/2018

• Cardiotonic Steroids Stimulate Macrophage Inflammatory Responses Through a Pathway Involving CD36, TLR4, and Na/K-ATPase.

  (Chen Y, Huang W, Yang M, Xin G, Cui W, Xie Z, Silverstein RL.) Arterioscler Thromb Vasc Biol. 2017 08;37(8):1462-1469 PMID: 28619997 PMCID: PMC5532064 SCOPUS ID: 2-s2.0-85020518621 06/18/2017

• Platelet CD36 promotes thrombosis by activating redox sensor ERK5 in hyperlipidemic conditions.

  (Yang M, Cooley BC, Li W, Chen Y, Vasquez-Vivar J, Scoggins NO, Cameron SJ, Morrell CN, Silverstein RL.) Blood. 2017 05 25;129(21):2917-2927 PMID: 28336528 PMCID: PMC5445574 SCOPUS ID: 2-s2.0-85019661296 03/25/2017

• Diet-induced obesity links to ER positive breast cancer progression via LPA/PKD-1-CD36 signaling-mediated microvascular remodeling.

  (Dong L, Yuan Y, Opansky C, Chen Y, Aguilera-Barrantes I, Wu S, Yuan R, Cao Q, Cheng YC, Sahoo D, Silverstein RL, Ren B.) Oncotarget. 2017 Apr 04;8(14):22550-22562 PMID: 28186980 PMCID: PMC5410244 SCOPUS ID: 2-s2.0-85016933174 02/12/2017

• Extracellular Vesicles Activate a CD36-Dependent Signaling Pathway to Inhibit Microvascular Endothelial Cell Migration and Tube Formation.

  (Ramakrishnan DP, Hajj-Ali RA, Chen Y, Silverstein RL.) Arterioscler Thromb Vasc Biol. 2016 Mar;36(3):534-44 PMID: 26821945 PMCID: PMC4767682 SCOPUS ID: 2-s2.0-84959464380 01/30/2016

• Oxidized LDL-bound CD36 recruits an Na⁺/K⁺-ATPase-Lyn complex in macrophages that promotes atherosclerosis.

  (Chen Y, Kennedy DJ, Ramakrishnan DP, Yang M, Huang W, Li Z, Xie Z, Chadwick AC, Sahoo D, Silverstein RL.) Sci Signal. 2015 Sep 08;8(393):ra91 PMID: 26350901 PMCID: PMC4852751 SCOPUS ID: 2-s2.0-84941034207 09/10/2015