Jonathan S. Marchant, MA, PhD

Marcus Professor & Chair

Locations

Cell Biology, Neurobiology & Anatomy, BSB4

Contact Information

jmarchant@mcw.edu

Education

PhD, Pharmacology, Cambridge University
Postdoctoral, Neurobiology & Behavior, UC Irvine, CA

Biography

Dr. Marchant received his PhD in Pharmacology from the University of Cambridge in the laboratory of Colin Taylor, and then performed post-doctoral training as a Wellcome Trust Training Fellow in Ian Parker’s laboratory in the Department of Neurobiology and Behavior at the University of California-Irvine. He was a Faculty Member in the Department of Pharmacology at the University of Minnesota from 2002-2017, until joining MCW as the Marcus Chair of Cell Biology, Neurobiology and Anatomy in 2017.

Connect with @MarchantLab on Twitter!

Research Areas of Interest

Antiparasitic Agents
Calcium Channels
Calcium Signaling
Endoplasmic Reticulum
Endosomes
Ion Channels
Lysosomes
Schistosomiasis

Research Experience

Fluorescent Dyes
Gene Silencing
High-Throughput Screening Assays
Membrane Proteins
Microinjections
Microscopy, Confocal
Planarians
RNA Interference
Signal Transduction

Research Interests

We are interested in the how cells respond to stimulation. Our focus is on signal transduction through Ca2+ signaling. Indeed, it is hard to think of any cellular process that is not regulated by Ca2+. Ca2+ signals can result from activation of intracellular Ca2+ channels and dysfunction of these same Ca2+ channels are involved in neurodegenerative disease and cancer. To appreciate how cell functions are controlled by Ca2+ signals, and how pathological cues subvert their function, we must understand how the distribution and the regulatory properties of intracellular Ca2+ channels control the genesis of Ca2+ signals.

NAADP-binding proteins find their identity.

(Marchant JS, Gunaratne GS, Cai X, Slama JT, Patel S.) Trends Biochem Sci. 2022 Mar;47(3):235-249 PMID: 34810081 PMCID: PMC8840967 SCOPUS ID: 2-s2.0-85119434188 11/24/2021
Activation of endo-lysosomal two-pore channels by NAADP and PI(3,5)P2. Five things to know.

(Patel S, Yuan Y, Gunaratne GS, Rahman T, Marchant JS.) Cell Calcium. May 2022;103 SCOPUS ID: 2-s2.0-85123908483 05/01/2022
The ins and outs of virus trafficking through acidic Ca2+ stores

(Gunaratne GS, Marchant JS.) Cell Calcium. March 2022;102 SCOPUS ID: 2-s2.0-85122655667 03/01/2022
Mechanism of praziquantel action at a parasitic flatworm ion channel.

(Park SK, Friedrich L, Yahya NA, Rohr CM, Chulkov EG, Maillard D, Rippmann F, Spangenberg T, Marchant JS.) Sci Transl Med. 2021 Dec 22;13(625):eabj5832 PMID: 34936384 PMCID: PMC8855674 SCOPUS ID: 2-s2.0-85122014054 12/23/2021
Genetic analysis of praziquantel response in schistosome parasites implicates a transient receptor potential channel.

(Le Clec'h W, Chevalier FD, Mattos ACA, Strickland A, Diaz R, McDew-White M, Rohr CM, Kinung'hi S, Allan F, Webster BL, Webster JP, Emery AM, Rollinson D, Djirmay AG, Al Mashikhi KM, Al Yafae S, Idris MA, Moné H, Mouahid G, LoVerde P, Marchant JS, Anderson TJC.) Sci Transl Med. 2021 Dec 22;13(625):eabj9114 PMID: 34936381 PMCID: PMC9491494 SCOPUS ID: 2-s2.0-85122006029 12/23/2021
Mechanisms of SARS-CoV-2 neutralization by shark variable new antigen receptors elucidated through X-ray crystallography.

(Ubah OC, Lake EW, Gunaratne GS, Gallant JP, Fernie M, Robertson AJ, Marchant JS, Bold TD, Langlois RA, Matchett WE, Thiede JM, Shi K, Yin L, Moeller NH, Banerjee S, Ferguson L, Kovaleva M, Porter AJ, Aihara H, LeBeau AM, Barelle CJ.) Nat Commun. 2021 Dec 16;12(1):7325 PMID: 34916516 PMCID: PMC8677774 SCOPUS ID: 2-s2.0-85121420979 12/18/2021
NAADP receptors: A one-two.

(Patel S, Gunaratne GS, Marchant JS, Biggin PC, Rahman T.) Cell Calcium. 2021 Dec;100:102478 PMID: 34600271 PMCID: PMC9552928 SCOPUS ID: 2-s2.0-85115958444 10/03/2021
Identification of novel modulators of a schistosome transient receptor potential channel targeted by praziquantel.

(Chulkov EG, Smith E, Rohr CM, Yahya NA, Park SK, Scampavia L, Spicer TP, Marchant JS.) PLoS Negl Trop Dis. 2021 Nov;15(11):e0009898 PMID: 34731172 PMCID: PMC8565742 SCOPUS ID: 2-s2.0-85120649827 11/04/2021
The sigma 1 receptor: A local media influencer.

(Rohr CM, Marchant JS.) Cell Calcium. 2021 Jun 01;97:102430 PMID: 34120081 SCOPUS ID: 2-s2.0-85107640347 06/14/2021
Mechanism of praziquantel action at a parasitic flatworm ion channel

(Park SK, Friedrich L, Yahya NA, Rohr CM, Chulkov EG, Maillard D, Rippmann F, Spangenberg T, Marchant JS.) Science Translational Medicine. 22 December 2021;13(625) SCOPUS ID: 2-s2.0-85122014054 12/22/2021
Genetic analysis of praziquantel response in schistosome parasites implicates a transient receptor potential channel

(Clec'h WL, Chevalier FD, Mattos ACA, Strickland A, Diaz R, McDew-White M, Rohr CM, Kinung'hi S, Allan F, Webster BL, Webster JP, Emery AM, Rollinson D, Djirmay AG, Al Mashikhi KM, Al Yafae S, Idris MA, Moné H, Mouahid G, LoVerde P, Marchant JS, Anderson TJC.) Science Translational Medicine. 22 December 2021;13(625) SCOPUS ID: 2-s2.0-85122006029 12/22/2021
Mechanisms of SARS-CoV-2 neutralization by shark variable new antigen receptors elucidated through X-ray crystallography

(Ubah OC, Lake EW, Gunaratne GS, Gallant JP, Fernie M, Robertson AJ, Marchant JS, Bold TD, Langlois RA, Matchett WE, Thiede JM, Shi K, Yin L, Moeller NH, Banerjee S, Ferguson L, Kovaleva M, Porter AJ, Aihara H, LeBeau AM, Barelle CJ.) Nature Communications. December 2021;12(1) SCOPUS ID: 2-s2.0-85121420979 12/01/2021

Cell Biology, Neurobiology and Anatomy (CBNA)