
Jonathan S. Marchant, MA, PhD
Marcus Professor & Chair
Locations
- Cell Biology, Neurobiology & Anatomy
Contact Information
Education
Postdoctoral, Department of Pharmacology, Cambridge University & Department of Neurobiology & Behavior, UC Irvine, CA
Biography
Dr. Marchant received his PhD in Pharmacology from the University of Cambridge in England in 1996, following which he was a Wellcome Trust Training Fellow in the Department of Pharmacology at the University of Cambridge from 1996 to 1998, and a Wellcome Trust International Training Fellow in the Department of Neurobiology and Behavior at the University of California-Irvine from 1998-2001.
He has been a faculty member at the University of Minnesota Medical School since 2002 and most recently served as a tenured professor in the Department of Pharmacology and Stem Cell Institute there. At the University of Minnesota Medical School’s Department of Pharmacology, Dr. Marchant held the positions of assistant professor, associate professor, director of graduate studies in pharmacology, interim head and vice head. He also has been a faculty member of the University’s Stem Cell Institute since 2008, where he serves on the executive leadership team and as Program Director of the T32 Graduate Training Program in Stem Cell Biology.
Research Experience
- Anthelmintics
- Calcium
- Calcium Channels
- Calcium Signaling
- Endoplasmic Reticulum
- Inositol 1,4,5-Trisphosphate Receptors
- Lysosomes
- Microscopy, Confocal
- Planarians
- Receptors, G-Protein-Coupled
- Regeneration
- Schistosomiasis
Research Interests
Dr. Marchant received training in leading laboratories that provided him with biochemical, molecular and imaging skill sets to probe the functional architecture of cell signaling events. As an independent principal investigator at the University of Minnesota, Dr. Marchant’s interests diversified to utilize these skill sets to advance a variety of projects in cellular and regenerative biology. He has been the recipient of more than a dozen grants from the National Institutes of Health (NIH) and the National Science Foundation (NSF), as well as numerous research awards and seed grants from the University of Minnesota.
He has been significantly involved in undergraduate, medical, graduate and postdoctoral education. He has mentored over 30 PhD, MS, Undergrad students and Postdoctoral Fellows. Dr. Marchant has also served on over 20 thesis committees in the past decade.
Dr. Marchant has published more than 80 articles, original papers, book chapters and reviews, and presented at nearly 20 local, regional, national and international lectures and workshops during the past five years. He has served as a panelist on numerous NSF and NIH Study Sections and as an ad hoc reviewer for national and international journals and granting bodies.
Publications
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The Journey to Discovering a Flatworm Target of Praziquantel: A Long TRP.
(Park SK, Marchant JS.) Trends Parasitol. 2020 02;36(2):182-194 PMID: 31787521 PMCID: PMC6937385 SCOPUS ID: 2-s2.0-85075830633 12/04/2019
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The anthelmintic drug praziquantel activates a schistosome transient receptor potential channel.
(Park SK, Gunaratne GS, Chulkov EG, Moehring F, McCusker P, Dosa PI, Chan JD, Stucky CL, Marchant JS.) J Biol Chem. 2019 12 06;294(49):18873-18880 PMID: 31653697 PMCID: PMC6901322 SCOPUS ID: 2-s2.0-85075816525 10/28/2019
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The synthesis and characterization of a clickable-photoactive NAADP analog active in human cells.
(Asfaha TY, Gunaratne GS, Johns ME, Marchant JS, Walseth TF, Slama JT.) Cell Calcium. 2019 11;83:102060 PMID: 31442840 PMCID: PMC6774857 SCOPUS ID: 2-s2.0-85070876728 08/24/2019
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Ca2+ Signaling and Regeneration.
(Marchant JS.) Cold Spring Harb Perspect Biol. 2019 11 01;11(11) PMID: 31308144 PMCID: PMC6824241 SCOPUS ID: 2-s2.0-85074378851 07/17/2019
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(Gunaratne GS, Su P, Marchant JS, Slama JT, Walseth TF.) Biochim Biophys Acta Mol Cell Res. 2019 07;1866(7):1180-1188 PMID: 30521871 SCOPUS ID: 2-s2.0-85057588907 12/07/2018
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TMEM33 regulates intracellular calcium homeostasis in renal tubular epithelial cells.
(Arhatte M, Gunaratne GS, El Boustany C, Kuo IY, Moro C, Duprat F, Plaisant M, Duval H, Li D, Picard N, Couvreux A, Duranton C, Rubera I, Pagnotta S, Lacas-Gervais S, Ehrlich BE, Marchant JS, Savage AM, van Eeden FJM, Wilkinson RN, Demolombe S, Honoré E, Patel A.) Nat Commun. 2019 05 02;10(1):2024 PMID: 31048699 PMCID: PMC6497644 SCOPUS ID: 2-s2.0-85065183745 05/03/2019
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(Subramanian VS, Sabui S, Marchant JS, Said HM.) J Nutr Biochem. 2019 03;65:46-53 PMID: 30616065 PMCID: PMC6420349 SCOPUS ID: 2-s2.0-85059472038 01/08/2019
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The synthesis and characterization of a clickable-photoactive NAADP analog active in human cells
(Asfaha TY, Gunaratne GS, Johns ME, Marchant JS, Walseth TF, Slama JT.) Cell Calcium. November 2019;83 SCOPUS ID: 2-s2.0-85070876728 11/01/2019
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Probing Ca2+ release mechanisms using sea urchin egg homogenates.
(Yuan Y, Gunaratne GS, Marchant JS, Patel S.) Methods Cell Biol. 2019;151:445-458 PMID: 30948025 SCOPUS ID: 2-s2.0-85061704699 04/06/2019
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The Journey to Discovering a Flatworm Target of Praziquantel: A Long TRP
(Park SK, Marchant JS.) Trends in Parasitology. 2019 SCOPUS ID: 2-s2.0-85075830633 01/01/2019
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(Subramenium GA, Sabui S, Marchant JS, Said HM, Subramanian VS.) Am J Physiol Gastrointest Liver Physiol. 2019 Jan 01;316(1):G55-G63 PMID: 30561232 SCOPUS ID: 2-s2.0-85058765526 12/19/2018
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(Marchant JS, Harding WW, Chan JD.) Int J Parasitol Drugs Drug Resist. 2018 12;8(3):550-558 PMID: 30297303 PMCID: PMC6287472 SCOPUS ID: 2-s2.0-85054495610 10/10/2018