TRE Lab Research
The team at the Tissue Regenerative Engineering Laboratory develops biomaterials and nanotechnology for regenerative engineering, tissue engineering, and drug delivery applications. Ongoing projects are outlined below.
Developing Small-Diameter Vascular Grafts with Human Amniotic Membrane
From Bone to Nanoparticles
Developing a Novel Generation of Nanoparticles with Acellular Porcine Bone for Potential Orthopedic Regeneration and Imaging
Cleft Palate Repair
Developing an amnion-based construction for dental and bone repair
Guided bone regeneration is a new concept in large bone defect therapy that employs a barrier membrane to afford a protected room for osteogenesis and prevents the invasion of fibroblasts. The TRE Lab is developing a novel barrier membrane made from human amnion membranes that can act as a shield to invading fibrous tissues, stabilize the bone grafts and induce the necessary massive bone growth required for repairing dental or bone defects.
Image: Cleft palate repair of control, cleft, DAM and DAM-POC (left to right) at 6 weeks in gross, CT and H&E views (top to bottom)
- Polymer Integrated Amnion Scaffold Significantly Improves Cleft Palate Repair
- Spatial and temporal changes of palatal cell proliferation and cell apoptosis of retinoic-acid-induced mouse cleft palate in different embryonic stages
- The study of palatal cell proliferation and apoptosis in retinoic-acid-induced mouse cleft palate varied with different developmental stages