Daisy Sahoo, PhD

Professor; Vice Chair Research; Secondary Faculty in Biochemistry and Pharmacology and Toxicology

Locations

Health Research Center
H4930

Contact Information

General Interests

Endocrine Pharmacology

Education

PhD, Biochemistry, University of Alberta, 2001

Learn more about the Daisy Sahoo Laboratory

Biography

Dr. Sahoo received her Bachelor of Science (Honors) degree in Biochemistry from the University of Ottawa (Canada) in 1995 and her Doctorate degree in Biochemistry from the University of Alberta (Canada) in 2001, where she applied fluorescence methodologies to study protein conformation. She pursued her postdoctoral work at Stony Brook University where she began her studies of SR-BI, the receptor for high density lipoprotein, HDL, or the “good cholesterol”. Dr. Sahoo joined the MCW faculty in 2007 and is currently Professor and Vice Chair for Research in the Department of Medicine. She also holds secondary appointments in the Departments of Biochemistry and Pharmacology & Toxicology. Dr. Sahoo is a member of MCW’s Cardiovascular Center, and is actively involved with the activities and leadership of the American Heart Association. Dr. Sahoo has had a long-standing interest in the role that scavenger receptors play in lipoprotein metabolism and diseases that include atherosclerosis, diabetes and obesity.

Leadership Positions

External

Chair, ATVB Irvine H. Page Young Investigator Award Selection Committee, ATVB Council of the American Heart Association
Vice Chair, Gordon Research Conference on Lipoprotein Metabolism
Member, Organizing Committee, 9th Annual HDL Workshop

MCW Internal

Vice Chair, Research, Department of Medicine
Member, Department of Medicine Research Committee
Member, Editorial Board of Biochemistry and Cell Biology
President, Faculty Council
Chair, Faculty Governance Committee
Member, Mentoring Committee, Interdisciplinary Program of Biomedical Sciences
Member, Women in Science Advisory Committee

Development and validation of a purification system for functional full-length human SR-B1 and CD36.

(Powers HR, Jenjak SE, Volkman BF, Sahoo D.) J Biol Chem. 2023 Oct;299(10):105187 PMID: 37625590 PMCID: PMC10509710 SCOPUS ID: 2-s2.0-85171377774 08/26/2023
Intracellular tPA-PAI-1 interaction determines VLDL assembly in hepatocytes.

(Dai W, Zhang H, Lund H, Zhang Z, Castleberry M, Rodriguez M, Kuriakose G, Gupta S, Lewandowska M, Powers HR, Valmiki S, Zhu J, Shapiro AD, Hussain MM, López JA, Sorci-Thomas MG, Silverstein RL, Ginsberg HN, Sahoo D, Tabas I, Zheng Z.) Science. 2023 Sep;381(6661):eadh5207 PMID: 37651538 PMCID: PMC10697821 SCOPUS ID: 2-s2.0-85169348601 08/31/2023
Scavenger receptor class B type I is required for efficient glucose uptake and metabolic homeostasis in adipocytes.

(Knaack DA, Chang J, Thomas MJ, Sorci-Thomas MG, Chen Y, Sahoo D.) bioRxiv. 2023 Aug 22 PMID: 37662321 PMCID: PMC10473602 09/04/2023
Contribution of adipocyte Na/K-ATPase α1/CD36 signaling induced exosome secretion in response to oxidized LDL.

(Pillai SS, Pereira DG, Zhang J, Huang W, Beg MA, Knaack DA, de Souza Goncalves B, Sahoo D, Silverstein RL, Shapiro JI, Sodhi K, Chen Y.) Front Cardiovasc Med. 2023;10:1046495 PMID: 37180782 PMCID: PMC10174328 SCOPUS ID: 2-s2.0-85159873988 05/14/2023
Na/K-ATPase suppresses LPS-induced pro-inflammatory signaling through Lyn.

(Zhang J, Chang J, Beg MA, Huang W, Zhao Y, Dai W, Wu X, Cui W, Pillai SS, Lakhani HV, Sodhi K, Shapiro JI, Sahoo D, Zheng Z, Silverstein RL, Chen Y.) iScience. 2022 Sep 16;25(9):104963 PMID: 36072548 PMCID: PMC9442361 SCOPUS ID: 2-s2.0-85137074779 09/09/2022
A short amphipathic alpha helix in scavenger receptor BI facilitates bidirectional HDL-cholesterol transport.

(May SC, Sahoo D.) J Biol Chem. 2022 Sep;298(9):102333 PMID: 35926711 PMCID: PMC9436806 SCOPUS ID: 2-s2.0-85136562503 08/05/2022
SR-B1's Next Top Model: Structural Perspectives on the Functions of the HDL Receptor.

(Powers HR, Sahoo D.) Curr Atheroscler Rep. 2022 Apr;24(4):277-288 PMID: 35107765 PMCID: PMC8809234 SCOPUS ID: 2-s2.0-85124168322 02/03/2022
Pcpe2, a Novel Extracellular Matrix Protein, Regulates Adipocyte SR-BI-Mediated High-Density Lipoprotein Uptake.

(Xu H, Thomas MJ, Kaul S, Kallinger R, Ouweneel AB, Maruko E, Oussaada SM, Jongejan A, Cense HA, Nieuwdorp M, Serlie MJ, Goldberg IJ, Civelek M, Parks BW, Lusis AJ, Knaack D, Schill RL, May SC, Reho JJ, Grobe JL, Gantner B, Sahoo D, Sorci-Thomas MG.) Arterioscler Thromb Vasc Biol. 2021 Nov;41(11):2708-2725 PMID: 34551590 PMCID: PMC8551036 SCOPUS ID: 2-s2.0-85118592107 09/24/2021
Low-Density Lipoprotein Receptor Suppresses the Endogenous Cholesterol Synthesis Pathway To Oppose Gammaherpesvirus Replication in Primary Macrophages.

(Aurubin CA, Knaack DA, Sahoo D, Tarakanova VL.) J Virol. 2021 Aug 10;95(17):e0064921 PMID: 34105999 PMCID: PMC8354329 SCOPUS ID: 2-s2.0-85112335753 06/10/2021
FFAR4: A New Player in Cardiometabolic Disease?

(Stuttgen GM, Sahoo D.) Endocrinology. 2021 Aug 01;162(8) PMID: 34043793 PMCID: PMC8218936 SCOPUS ID: 2-s2.0-85109115515 05/28/2021
Now in 3D! Novel insights into CD36 structure and function

(May SC, Sahoo D.) Annals of Blood. December 2021;6 SCOPUS ID: 2-s2.0-85122564281 12/01/2021
Human variant of scavenger receptor BI (R174C) exhibits impaired cholesterol transport functions.

(May SC, Dron JS, Hegele RA, Sahoo D.) J Lipid Res. 2021;62:100045 PMID: 33577783 PMCID: PMC7985710 SCOPUS ID: 2-s2.0-85104445414 02/13/2021