Daisy Sahoo, PhD

Vice Chair for Research, Division of Endocrinology and Molecular Medicine; Professor, Medicine (Endocrinology); Secondary Faculty in Biochemistry and Pharmacology and Toxicology

Locations

Health Research Center
H4930

Contact Information

General Interests

Endocrine Pharmacology

Education

PhD, Biochemistry, University of Alberta, 2001

Learn more about the Daisy Sahoo Laboratory

Biography

Dr. Sahoo received her Bachelor of Science (Honors) degree in Biochemistry from the University of Ottawa (Canada) in 1995 and her Doctorate degree in Biochemistry from the University of Alberta (Canada) in 2001, where she applied fluorescence methodologies to study protein conformation. She pursued her postdoctoral work at Stony Brook University where she began her studies of SR-BI, the receptor for high density lipoprotein, HDL, or the “good cholesterol”. Dr. Sahoo joined the MCW faculty in 2007 and is currently Professor and Vice Chair for Research in the Department of Medicine. She also holds secondary appointments in the Departments of Biochemistry and Pharmacology & Toxicology. Dr. Sahoo is a member of MCW’s Cardiovascular Center, and is actively involved with the activities and leadership of the American Heart Association. Dr. Sahoo has had a long-standing interest in the role that scavenger receptors play in lipoprotein metabolism and diseases that include atherosclerosis, diabetes and obesity.

Leadership Positions

External

Chair, ATVB Irvine H. Page Young Investigator Award Selection Committee, ATVB Council of the American Heart Association
Vice Chair, Gordon Research Conference on Lipoprotein Metabolism
Member, Organizing Committee, 9th Annual HDL Workshop

MCW Internal

Vice Chair, Research, Department of Medicine
Member, Department of Medicine Research Committee
Member, Editorial Board of Biochemistry and Cell Biology
President, Faculty Council
Chair, Faculty Governance Committee
Member, Mentoring Committee, Interdisciplinary Program of Biomedical Sciences
Member, Women in Science Advisory Committee

Human variant of scavenger receptor BI (R174C) exhibits impaired cholesterol transport functions.

(May SC, Dron JS, Hegele RA, Sahoo D.) J Lipid Res. 2021 Feb 09;62:100045 PMID: 33577783 PMCID: PMC7985710 02/13/2021
Modification of HDL by reactive aldehydes alters select cardioprotective functions of HDL in macrophages.

(Schill RL, Knaack DA, Powers HR, Chen Y, Yang M, Schill DJ, Silverstein RL, Sahoo D.) FEBS J. 2020 02;287(4):695-707 PMID: 31386799 PMCID: PMC7002295 SCOPUS ID: 2-s2.0-85070750063 08/07/2019
Mitochondrial Metabolic Reprogramming by CD36 Signaling Drives Macrophage Inflammatory Responses.

(Chen Y, Yang M, Huang W, Chen W, Zhao Y, Schulte ML, Volberding P, Gerbec Z, Zimmermann MT, Zeighami A, Demos W, Zhang J, Knaack DA, Smith BC, Cui W, Malarkannan S, Sodhi K, Shapiro JI, Xie Z, Sahoo D, Silverstein RL.) Circ Res. 2019 12 06;125(12):1087-1102 PMID: 31625810 PMCID: PMC6921463 SCOPUS ID: 2-s2.0-85076330129 10/19/2019
Proceedings of the Ninth HDL (High-Density Lipoprotein) Workshop: Focus on Cardiovascular Disease.

(Rodriguez A, Trigatti BL, Mineo C, Knaack D, Wilkins JT, Sahoo D, Asztalos BF, Mora S, Cuchel M, Pownall HJ, Rosales C, Bernatchez P, Ribeiro Martins da Silva A, Getz GS, Barber JL, Shearer GC, Zivkovic AM, Tietge UJF, Sacks FM, Connelly MA, Oda MN, Davidson WS, Sorci-Thomas MG, Vaisar T, Ruotolo G, Vickers KC, Martel C.) Arterioscler Thromb Vasc Biol. 2019 12;39(12):2457-2467 PMID: 31597448 PMCID: PMC6937204 SCOPUS ID: 2-s2.0-85075813183 10/11/2019
Proline residues in scavenger receptor-BI's C-terminal region support efficient cholesterol transport.

(Proudfoot SC, Sahoo D.) Biochem J. 2019 03 22;476(6):951-963 PMID: 30837308 PMCID: PMC6430181 SCOPUS ID: 2-s2.0-85063681808 03/07/2019
Liver X Receptors Suppress Activity of Cholesterol and Fatty Acid Synthesis Pathways To Oppose Gammaherpesvirus Replication.

(Lange PT, Schorl C, Sahoo D, Tarakanova VL.) mBio. 2018 07 17;9(4) PMID: 30018108 PMCID: PMC6050960 SCOPUS ID: 2-s2.0-85055540133 07/19/2018
Effect of adiposity on tissue-specific adiponectin secretion.

(Reneau J, Goldblatt M, Gould J, Kindel T, Kastenmeier A, Higgins R, Rengel LR, Schoyer K, James R, Obi B, Moosreiner A, Nicholson K, Sahoo D, Kidambi S.) PLoS One. 2018;13(6):e0198889 PMID: 29924824 PMCID: PMC6010237 SCOPUS ID: 2-s2.0-85048771061 06/21/2018
Diet-induced obesity links to ER positive breast cancer progression via LPA/PKD-1-CD36 signaling-mediated microvascular remodeling.

(Dong L, Yuan Y, Opansky C, Chen Y, Aguilera-Barrantes I, Wu S, Yuan R, Cao Q, Cheng YC, Sahoo D, Silverstein RL, Ren B.) Oncotarget. 2017 Apr 04;8(14):22550-22562 PMID: 28186980 PMCID: PMC5410244 SCOPUS ID: 2-s2.0-85016933174 02/12/2017
NMR Structure of the C-Terminal Transmembrane Domain of the HDL Receptor, SR-BI, and a Functionally Relevant Leucine Zipper Motif.

(Chadwick AC, Jensen DR, Hanson PJ, Lange PT, Proudfoot SC, Peterson FC, Volkman BF, Sahoo D.) Structure. 2017 03 07;25(3):446-457 PMID: 28162952 PMCID: PMC5575897 SCOPUS ID: 2-s2.0-85011284406 02/07/2017
Domain Mapping of Heat Shock Protein 70 Reveals That Glutamic Acid 446 and Arginine 447 Are Critical for Regulating Superoxide Dismutase 2 Function.

(Afolayan AJ, Alexander M, Holme RL, Michalkiewicz T, Rana U, Teng RJ, Zemanovic S, Sahoo D, Pritchard KA Jr, Konduri GG.) J Biol Chem. 2017 02 10;292(6):2369-2378 PMID: 28028182 PMCID: PMC5313107 SCOPUS ID: 2-s2.0-85012108909 12/29/2016
Tryptophan 415 Is Critical for the Cholesterol Transport Functions of Scavenger Receptor BI.

(Holme RL, Miller JJ, Nicholson K, Sahoo D.) Biochemistry. 2016 Jan 12;55(1):103-13 PMID: 26652912 PMCID: PMC5428993 SCOPUS ID: 2-s2.0-84954457161 12/15/2015
Oxidized LDL-bound CD36 recruits an Na⁺/K⁺-ATPase-Lyn complex in macrophages that promotes atherosclerosis.

(Chen Y, Kennedy DJ, Ramakrishnan DP, Yang M, Huang W, Li Z, Xie Z, Chadwick AC, Sahoo D, Silverstein RL.) Sci Signal. 2015 Sep 08;8(393):ra91 PMID: 26350901 PMCID: PMC4852751 SCOPUS ID: 2-s2.0-84941034207 09/10/2015

Endocrinology and Molecular Medicine