Daisy Sahoo, PhD
Vice Chair for Research, Division of Endocrinology and Molecular Medicine; Professor, Medicine (Endocrinology); Secondary Faculty in Biochemistry and Pharmacology and Toxicology
- Health Research Center
Dr. Sahoo received her Bachelor of Science (Honors) degree in Biochemistry from the University of Ottawa (Canada) in 1995 and her Doctorate degree in Biochemistry from the University of Alberta (Canada) in 2001, where she applied fluorescence methodologies to study protein conformation. She pursued her postdoctoral work at Stony Brook University where she began her studies of SR-BI, the receptor for high density lipoprotein, HDL, or the “good cholesterol”. Dr. Sahoo joined the MCW faculty in 2007 and is currently Professor and Vice Chair for Research in the Department of Medicine. She also holds secondary appointments in the Departments of Biochemistry and Pharmacology & Toxicology. Dr. Sahoo is a member of MCW’s Cardiovascular Center, and is actively involved with the activities and leadership of the American Heart Association. Dr. Sahoo has had a long-standing interest in the role that scavenger receptors play in lipoprotein metabolism and diseases that include atherosclerosis, diabetes and obesity.
- Chair, ATVB Irvine H. Page Young Investigator Award Selection Committee, ATVB Council of the American Heart Association
- Vice Chair, Gordon Research Conference on Lipoprotein Metabolism
- Member, Organizing Committee, 9th Annual HDL Workshop
- Vice Chair, Research, Department of Medicine
- Member, Department of Medicine Research Committee
- Member, Editorial Board of Biochemistry and Cell Biology
- President, Faculty Council
- Chair, Faculty Governance Committee
- Member, Mentoring Committee, Interdisciplinary Program of Biomedical Sciences
- Member, Women in Science Advisory Committee
Na/K-ATPase suppresses LPS-induced pro-inflammatory signaling through Lyn.
(Zhang J, Chang J, Beg MA, Huang W, Zhao Y, Dai W, Wu X, Cui W, Pillai SS, Lakhani HV, Sodhi K, Shapiro JI, Sahoo D, Zheng Z, Silverstein RL, Chen Y.) iScience. 2022 Sep 16;25(9):104963 PMID: 36072548 PMCID: PMC9442361 SCOPUS ID: 2-s2.0-85137074779 09/09/2022
A short amphipathic alpha helix in scavenger receptor BI facilitates bidirectional HDL-cholesterol transport.
(May SC, Sahoo D.) J Biol Chem. 2022 Sep;298(9):102333 PMID: 35926711 PMCID: PMC9436806 SCOPUS ID: 2-s2.0-85136562503 08/05/2022
Regulation of Adipocyte Metabolic Homeostasis by SR-BI and PCPE2.
(Knaack DA, Sorci-Thomas MG, Thomas MJ, Chen Y, Sahoo D.) FASEB J. 2022 May;36 Suppl 1 PMID: 35553852 SCOPUS ID: 2-s2.0-85130030599 05/14/2022
A Tale of Two Scavenger Receptors: Structure-Function Relationships of Purified SR-B1 and CD36.
(Powers HR, Jenjak SE, Volkman BF, Sahoo D.) FASEB J. 2022 May;36 Suppl 1 PMID: 35552332 SCOPUS ID: 2-s2.0-85130046210 05/14/2022
Novel Roles of FFAR4 in Macrophage Foam Cell Formation
(Stuttgen GM, Sahoo D.) FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 1 May 2022;36 PMID: 35553911 SCOPUS ID: 2-s2.0-85130053642 05/01/2022
SR-B1's Next Top Model: Structural Perspectives on the Functions of the HDL Receptor.
(Powers HR, Sahoo D.) Curr Atheroscler Rep. 2022 Apr;24(4):277-288 PMID: 35107765 PMCID: PMC8809234 SCOPUS ID: 2-s2.0-85124168322 02/03/2022
Pcpe2, a Novel Extracellular Matrix Protein, Regulates Adipocyte SR-BI-Mediated High-Density Lipoprotein Uptake.
(Xu H, Thomas MJ, Kaul S, Kallinger R, Ouweneel AB, Maruko E, Oussaada SM, Jongejan A, Cense HA, Nieuwdorp M, Serlie MJ, Goldberg IJ, Civelek M, Parks BW, Lusis AJ, Knaack D, Schill RL, May SC, Reho JJ, Grobe JL, Gantner B, Sahoo D, Sorci-Thomas MG.) Arterioscler Thromb Vasc Biol. 2021 Nov;41(11):2708-2725 PMID: 34551590 PMCID: PMC8551036 SCOPUS ID: 2-s2.0-85118592107 09/24/2021
Low-Density Lipoprotein Receptor Suppresses the Endogenous Cholesterol Synthesis Pathway To Oppose Gammaherpesvirus Replication in Primary Macrophages.
(Aurubin CA, Knaack DA, Sahoo D, Tarakanova VL.) J Virol. 2021 Aug 10;95(17):e0064921 PMID: 34105999 PMCID: PMC8354329 SCOPUS ID: 2-s2.0-85112335753 06/10/2021
FFAR4: A New Player in Cardiometabolic Disease?
(Stuttgen GM, Sahoo D.) Endocrinology. 2021 Aug 01;162(8) PMID: 34043793 PMCID: PMC8218936 SCOPUS ID: 2-s2.0-85109115515 05/28/2021
Now in 3D! Novel insights into CD36 structure and function
(May SC, Sahoo D.) Annals of Blood. December 2021;6 SCOPUS ID: 2-s2.0-85122564281 12/01/2021
Human variant of scavenger receptor BI (R174C) exhibits impaired cholesterol transport functions.
(May SC, Dron JS, Hegele RA, Sahoo D.) J Lipid Res. 2021;62:100045 PMID: 33577783 PMCID: PMC7985710 SCOPUS ID: 2-s2.0-85104445414 02/13/2021
Mitochondrial Metabolic Reprogramming by CD36 Signaling Drives Macrophage Inflammatory Responses.
(Chen Y, Yang M, Huang W, Chen W, Zhao Y, Schulte ML, Volberding P, Gerbec Z, Zimmermann MT, Zeighami A, Demos W, Zhang J, Knaack DA, Smith BC, Cui W, Malarkannan S, Sodhi K, Shapiro JI, Xie Z, Sahoo D, Silverstein RL.) Circ Res. 2019 Dec 06;125(12):1087-1102 PMID: 31625810 PMCID: PMC6921463 SCOPUS ID: 2-s2.0-85076330129 10/19/2019