Daisy Sahoo, PhD

Vice Chair for Research, Division of Endocrinology and Molecular Medicine; Professor, Medicine (Endocrinology); Secondary Faculty in Biochemistry and Pharmacology and Toxicology

Locations

Health Research Center
H4930

Contact Information

General Interests

Endocrine Pharmacology

Education

PhD, Biochemistry, University of Alberta, 2001

Learn more about the Daisy Sahoo Laboratory

Biography

Dr. Sahoo received her Bachelor of Science (Honors) degree in Biochemistry from the University of Ottawa (Canada) in 1995 and her Doctorate degree in Biochemistry from the University of Alberta (Canada) in 2001, where she applied fluorescence methodologies to study protein conformation. She pursued her postdoctoral work at Stony Brook University where she began her studies of SR-BI, the receptor for high density lipoprotein, HDL, or the “good cholesterol”. Dr. Sahoo joined the MCW faculty in 2007 and is currently Professor and Vice Chair for Research in the Department of Medicine. She also holds secondary appointments in the Departments of Biochemistry and Pharmacology & Toxicology. Dr. Sahoo is a member of MCW’s Cardiovascular Center, and is actively involved with the activities and leadership of the American Heart Association. Dr. Sahoo has had a long-standing interest in the role that scavenger receptors play in lipoprotein metabolism and diseases that include atherosclerosis, diabetes and obesity.

Leadership Positions

External

Chair, ATVB Irvine H. Page Young Investigator Award Selection Committee, ATVB Council of the American Heart Association
Vice Chair, Gordon Research Conference on Lipoprotein Metabolism
Member, Organizing Committee, 9th Annual HDL Workshop

MCW Internal

Vice Chair, Research, Department of Medicine
Member, Department of Medicine Research Committee
Member, Editorial Board of Biochemistry and Cell Biology
President, Faculty Council
Chair, Faculty Governance Committee
Member, Mentoring Committee, Interdisciplinary Program of Biomedical Sciences
Member, Women in Science Advisory Committee

SR-B1's Next Top Model: Structural Perspectives on the Functions of the HDL Receptor.

(Powers HR, Sahoo D.) Curr Atheroscler Rep. 2022 04;24(4):277-288 PMID: 35107765 PMCID: PMC8809234 SCOPUS ID: 2-s2.0-85124168322 02/03/2022
Pcpe2, a Novel Extracellular Matrix Protein, Regulates Adipocyte SR-BI-Mediated High-Density Lipoprotein Uptake.

(Xu H, Thomas MJ, Kaul S, Kallinger R, Ouweneel AB, Maruko E, Oussaada SM, Jongejan A, Cense HA, Nieuwdorp M, Serlie MJ, Goldberg IJ, Civelek M, Parks BW, Lusis AJ, Knaack D, Schill RL, May SC, Reho JJ, Grobe JL, Gantner B, Sahoo D, Sorci-Thomas MG.) Arterioscler Thromb Vasc Biol. 2021 11;41(11):2708-2725 PMID: 34551590 PMCID: PMC8551036 SCOPUS ID: 2-s2.0-85118592107 09/24/2021
Low-Density Lipoprotein Receptor Suppresses the Endogenous Cholesterol Synthesis Pathway To Oppose Gammaherpesvirus Replication in Primary Macrophages.

(Aurubin CA, Knaack DA, Sahoo D, Tarakanova VL.) J Virol. 2021 08 10;95(17):e0064921 PMID: 34105999 PMCID: PMC8354329 SCOPUS ID: 2-s2.0-85112335753 06/10/2021
FFAR4: A New Player in Cardiometabolic Disease?

(Stuttgen GM, Sahoo D.) Endocrinology. 2021 08 01;162(8) PMID: 34043793 PMCID: PMC8218936 SCOPUS ID: 2-s2.0-85109115515 05/28/2021
Now in 3D! Novel insights into CD36 structure and function

(May SC, Sahoo D.) Annals of Blood. December 2021;6 SCOPUS ID: 2-s2.0-85122564281 12/01/2021
Human variant of scavenger receptor BI (R174C) exhibits impaired cholesterol transport functions.

(May SC, Dron JS, Hegele RA, Sahoo D.) J Lipid Res. 2021;62:100045 PMID: 33577783 PMCID: PMC7985710 SCOPUS ID: 2-s2.0-85104445414 02/13/2021
Modification of HDL by reactive aldehydes alters select cardioprotective functions of HDL in macrophages.

(Schill RL, Knaack DA, Powers HR, Chen Y, Yang M, Schill DJ, Silverstein RL, Sahoo D.) FEBS J. 2020 02;287(4):695-707 PMID: 31386799 PMCID: PMC7002295 SCOPUS ID: 2-s2.0-85070750063 08/07/2019
Mitochondrial Metabolic Reprogramming by CD36 Signaling Drives Macrophage Inflammatory Responses.

(Chen Y, Yang M, Huang W, Chen W, Zhao Y, Schulte ML, Volberding P, Gerbec Z, Zimmermann MT, Zeighami A, Demos W, Zhang J, Knaack DA, Smith BC, Cui W, Malarkannan S, Sodhi K, Shapiro JI, Xie Z, Sahoo D, Silverstein RL.) Circ Res. 2019 12 06;125(12):1087-1102 PMID: 31625810 PMCID: PMC6921463 SCOPUS ID: 2-s2.0-85076330129 10/19/2019
Proceedings of the Ninth HDL (High-Density Lipoprotein) Workshop: Focus on Cardiovascular Disease.

(Rodriguez A, Trigatti BL, Mineo C, Knaack D, Wilkins JT, Sahoo D, Asztalos BF, Mora S, Cuchel M, Pownall HJ, Rosales C, Bernatchez P, Ribeiro Martins da Silva A, Getz GS, Barber JL, Shearer GC, Zivkovic AM, Tietge UJF, Sacks FM, Connelly MA, Oda MN, Davidson WS, Sorci-Thomas MG, Vaisar T, Ruotolo G, Vickers KC, Martel C.) Arterioscler Thromb Vasc Biol. 2019 12;39(12):2457-2467 PMID: 31597448 PMCID: PMC6937204 SCOPUS ID: 2-s2.0-85075813183 10/11/2019
Proline residues in scavenger receptor-BI's C-terminal region support efficient cholesterol transport.

(Proudfoot SC, Sahoo D.) Biochem J. 2019 03 22;476(6):951-963 PMID: 30837308 PMCID: PMC6430181 SCOPUS ID: 2-s2.0-85063681808 03/07/2019
Liver X Receptors Suppress Activity of Cholesterol and Fatty Acid Synthesis Pathways To Oppose Gammaherpesvirus Replication.

(Lange PT, Schorl C, Sahoo D, Tarakanova VL.) mBio. 2018 07 17;9(4) PMID: 30018108 PMCID: PMC6050960 SCOPUS ID: 2-s2.0-85055540133 07/19/2018
Effect of adiposity on tissue-specific adiponectin secretion.

(Reneau J, Goldblatt M, Gould J, Kindel T, Kastenmeier A, Higgins R, Rengel LR, Schoyer K, James R, Obi B, Moosreiner A, Nicholson K, Sahoo D, Kidambi S.) PLoS One. 2018;13(6):e0198889 PMID: 29924824 PMCID: PMC6010237 SCOPUS ID: 2-s2.0-85048771061 06/21/2018

Endocrinology and Molecular Medicine