Roy Silverstein, MD

Publications

• A CD36 transmembrane domain peptide interrupts CD36 interactions with membrane partners on macrophages and inhibits atherogenic functions.

  (Huang W, Li R, Zhang J, Cheng Y, Ramakrishnan DP, Silverstein RL.) Transl Res. 2023 Apr;254:68-76 PMID: 36377115 SCOPUS ID: 2-s2.0-85143169438 11/16/2022

• Contribution of adipocyte Na/K-ATPase α1/CD36 signaling induced exosome secretion in response to oxidized LDL.

  (Pillai SS, Pereira DG, Zhang J, Huang W, Beg MA, Knaack DA, de Souza Goncalves B, Sahoo D, Silverstein RL, Shapiro JI, Sodhi K, Chen Y.) Front Cardiovasc Med. 2023;10:1046495 PMID: 37180782 PMCID: PMC10174328 05/14/2023

• Na/K-ATPase suppresses LPS-induced pro-inflammatory signaling through Lyn.

  (Zhang J, Chang J, Beg MA, Huang W, Zhao Y, Dai W, Wu X, Cui W, Pillai SS, Lakhani HV, Sodhi K, Shapiro JI, Sahoo D, Zheng Z, Silverstein RL, Chen Y.) iScience. 2022 Sep 16;25(9):104963 PMID: 36072548 PMCID: PMC9442361 SCOPUS ID: 2-s2.0-85137074779 09/09/2022

• CD36, a signaling receptor and fatty acid transporter that regulates immune cell metabolism and fate.

  (Chen Y, Zhang J, Cui W, Silverstein RL.) J Exp Med. 2022 Jun 06;219(6) PMID: 35438721 PMCID: PMC9022290 SCOPUS ID: 2-s2.0-85128794972 04/20/2022

• Plasma Membrane Localization of CD36 Requires Vimentin Phosphorylation; A Mechanism by Which Macrophage Vimentin Promotes Atherosclerosis.

  (Kim SY, Jeong SJ, Park JH, Cho W, Ahn YH, Choi YH, Oh GT, Silverstein RL, Park YM.) Front Cardiovasc Med. 2022;9:792717 PMID: 35656400 PMCID: PMC9152264 06/04/2022

• AMPK-deficiency forces metformin-challenged cancer cells to switch from carbohydrate metabolism to ketogenesis to support energy metabolism.

  (Palma FR, Ratti BA, Paviani V, Coelho DR, Miguel R, Danes JM, Zaichik SV, de Abreu AL, Silva SO, Chen Y, Silverstein RL, Karan U, Jones DP, Bonini MG.) Oncogene. 2021 Sep;40(36):5455-5467 PMID: 34290400 PMCID: PMC8669831 SCOPUS ID: 2-s2.0-85110982210 07/23/2021

• PCSK9 (Proprotein Convertase Subtilisin/Kexin 9) Goes DAMP.

  (Silverstein RL.) Circulation. 2021 Jan 05;143(1):62-64 PMID: 33378238 PMCID: PMC8006907 SCOPUS ID: 2-s2.0-85099206085 12/31/2020

• Development of an arteriolar niche and self-renewal of breast cancer stem cells by lysophosphatidic acid/protein kinase D signaling

  (Jiang Y, Guo Y, Hao J, Guenter R, Lathia J, Beck AW, Hattaway R, Hurst D, Wang QJ, Liu Y, Cao Q, Krontiras H, Chen H, Silverstein R, Ren B.) Communications Biology. December 2021;4(1) SCOPUS ID: 2-s2.0-85108778647 12/01/2021

• Hypertriglyceridemia during hospitalization independently associates with mortality in patients with COVID-19.

  (Dai W, Lund H, Chen Y, Zhang J, Osinski K, Jones SZ, Kreuziger LB, López JA, Benjamin IJ, Silverstein RL, Zheng Z.) J Clin Lipidol. 2021;15(5):724-731 PMID: 34470719 PMCID: PMC8353976 SCOPUS ID: 2-s2.0-85114047849 09/03/2021

• Cysteine sulfenylation by CD36 signaling promotes arterial thrombosis in dyslipidemia.

  (Yang M, Li W, Harberg C, Chen W, Yue H, Ferreira RB, Wynia-Smith SL, Carroll KS, Zielonka J, Flaumenhaft R, Silverstein RL, Smith BC.) Blood Adv. 2020 Sep 22;4(18):4494-4507 PMID: 32946569 PMCID: PMC7509873 SCOPUS ID: 2-s2.0-85092260584 09/19/2020

• Oxidant-induced alterations in the adipocyte transcriptome: Role of the na,k-atpase oxidant amplification loop

  (Sodhi K, Denvir J, Liu J, Sanabria JR, Chen Y, Silverstein R, Xie Z, Abraham NG, Shapiro JI.) International Journal of Molecular Sciences. 2 August 2020;21(16):1-25 SCOPUS ID: 2-s2.0-85089702929 08/02/2020

• Mitochondrial Metabolic Reprogramming by CD36 Signaling Drives Macrophage Inflammatory Responses.

  (Chen Y, Yang M, Huang W, Chen W, Zhao Y, Schulte ML, Volberding P, Gerbec Z, Zimmermann MT, Zeighami A, Demos W, Zhang J, Knaack DA, Smith BC, Cui W, Malarkannan S, Sodhi K, Shapiro JI, Xie Z, Sahoo D, Silverstein RL.) Circ Res. 2019 Dec 06;125(12):1087-1102 PMID: 31625810 PMCID: PMC6921463 SCOPUS ID: 2-s2.0-85076330129 10/19/2019