One focus where we continue to make great strides is in understanding cartilage biology. Cartilage is certainly a crucial structure within the joints. Damage to the cartilage leads to loss of function and considerable discomfort. We continue to educate future generations of clinical rheumatologists and researchers in the arthritis arena.
The Rosenthal Laboratory has continued this important work. The laboratory is situated at the Zablocki VA Medical Center and has been federally funded since 1996. Dr. Rosenthal has focused most of her work on studies of calcium pyrophosphate crystal formation. She began by identifying mechanisms and modulators of pyrophosphate production by cartilage cells. More recently she has been using genetic abnormalities responsible for familial CPDD to study novel pathogenic mechanisms of crystal formation. These studies involve in-vitro experiments with bone and cartilage tissues, as well as work with novel mouse models. Dr. Rosenthal has also worked with data from the national VA Health Care system to characterize CPDD and its sequelae in the US veteran population. She collaborates with investigators at Washington University in St. Louis, Brigham and Women’s Hospital and Harvard Medical School, and Cooper Medical School of Rowan University. Her laboratory is well-staffed with expert research associates and has served as a training ground for numerous rheumatology fellows, residents, and medical students. Dr. Rosenthal is the author of over 100 papers, chapters and invited reviews and frequently speaks on CPDD at national and international meetings.