Medical College of Wisconsin Liu Laboratory Research
What does it take to regenerate a heart?
Direct Cardiac Reprogramming
Molecular mechanisms of angiogenesis
Publications
2024
24. Liu Z, Tanke NT, Neal AG, Yu T, Branch T, Sharma A, Cook JG, Bautch VL (2024). Differential endothelial cell cycle status in post-natal retinal vessels revealed using a novel PIP-FUCCI reporter. Angiogenesis. (2024).
23. Tanke NT, Liu Z, Gore MT, Bougaran P, Linares MB, Marvin AP, Sharma A, Oatley M, Yu T, Quigley KM, Vest S, Cook JG and Bautch VL (2024). Endothelial Cell Flow-Mediated Quiescence Is Temporally Regulated and Utilizes the Cell Cycle Inhibitor p27. Arteriosclerosis, Thrombosis, and Vascular Biology. 11 Apr 2024:ATVBAHA.124.320671.
2023
22. Kulikauskas MR, Oatley M, Yu T, Liu Z, Matsumura L, Kidder EJ, Ruter DL, Bautch VL (2023). Endothelial Cell SMAD6 Balances ACVRL1/Alk1 Function to Regulate Adherens Junctions And Hepatic Vascular Development. Development. 2023 Oct 3:dev.201811.
21. Buglak DB, Bougaran P, Kulikauskas MR, Liu Z, Monaghan-Benson E, Gold AL, Marvin AP, Burciu A, Tanke NT, Oatley M, Ricketts SN, Kinghorn K, Johnson BN, Shiau CE, Rogers S, Guilluy C, Bautch VL (2023). Nuclear SUN1 stabilizes endothelial cell junctions via microtubules to regulate blood vessel formation. eLife 12:e83652.
2021
20. Liu Z, Ruter DL, Quigley KM, Tanke N, Jiang Y, Bautch VL (2021). Single-Cell RNA Sequencing Reveals Endothelial Cell Transcriptome Heterogeneity under Homeostatic Laminar Flow. Arteriosclerosis, Thrombosis, and Vascular Biology. 2021 Aug 26: ATVBAHA121316797. Featured article of the issue.
19. Ruter DL, Liu Z, Ngo KM, X S, Marvin A, Buglak DB, Kidder EJ, Bautch VL (2021). SMAD6 Integrates Endothelial Cell Homeostatic Flow Responses Downstream of Notch. Angiogenesis. 2021 May;24(2):387-398.
18. Ma H*, Liu Z*, Yang Y*, Feng D, Dong Y, Garbutt T, Hu Z, Wang L, Luan H, Cooper C, Li Y, Welch J, Qian L, Liu J (2021). Functional Coordination of Non-myocytes Plays a Key Role in Adult Zebrafish Heart Regeneration. EMBO Reports. 2021 e52901 https://doi.org/10.15252/embr.202152901. *co-first author.
2020
17. Wang L, Ma H, Huang P, Xie Y, Near D, Wang H, Xu J, Yang Y, Xu Y, Garbutt T, Zhou Y, Liu Z, Yin C, Bressan M, Taylor JM, Liu JD Qian L (2020). Downregulation of Beclin1 Promotes Direct Cardiac Reprogramming. Sci Transl Med 12(566): eaay7856.2019
16. Zhou Y*, Liu Z*, Welch JD, Gao X, Wang L, Garbutt T, Keepers B, Ma H, Prins JF, Shen WN, Liu JD, Qian L (2019). Single-Cell Transcriptomic Analyses of Cell Fate Transitions during Human Cardiac Reprogramming. Cell Stem Cell 25 (1), 149-164. *co-first author.
15. Ma H, Yu S, Liu X, Zhang Y, Fakadej T, Liu Z, Yin CY, Shen WN, Locasale JW, Taylor JM, Qian L, Liu JD (2019). Lin28a Regulates Pathological Cardiac Hypertrophic Growth through Pck2-Mediated Enhancement of Anabolic Synthesis. Circulation 139 (14), 1725-1740.
2018
14. Zhou Y, Alimohamadi S, Wang L, Liu Z, Wall JB, Yin C, Liu J, Qian L (2018). A Loss of Function Screen of Epigenetic Modifiers and Splicing Factors during Early Stage of Cardiac Reprogramming. Stem Cells International.2017
13. Liu Z*, Wang L*, Welch JD*, Ma H, Zhou Y, Vaseghi HR, Yu S, Wall JB, Alimohamadi S, Zheng M, Yin CY, Shen WN, Prins JF, Liu JD, Qian L (2017). Single Cell Transcriptomics Reconstructs Lineage Conversion from Fibroblast to Cardiomyocyte. Nature 551, 100-104 *co-first author.
12. Zhou Y, Wang L, Liu Z, Alimohamadi S, Yin CY, Liu JD, Qian L (2017). Comparative Gene Expression Analyses Reveal Distinct Molecular Signature between Induced Cardiomyocytes and Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Cell Reports 20 (13), 3014-3024.
11. Liu Z, Chen O, Wall JB, Zheng M, Zhou Y, Wang L, Vaseghi HR, Qian L, Liu JD (2017). Systematic Comparison of 2A Peptides for Cloning Multi-Genes in a Polycistronic Vector. Scientific Reports 7: 2193.
2016
10. Liu Z, Chen O, Zheng M, Wang L, Zhou Y, Yin CY, Liu JD, Qian L (2016). Re-Patterning of H3k27me3, H3k4me3 and DNA Methylation during Fibroblast Conversion into Induced Cardiomyocytes. Stem Cell Research 16 (2), 507–518.
9. Zhou Y, Wang L, Vaseghi HR, Liu Z, Lu R, Alimohamadi S, Yin CY, Fu JD, Wang GG, Liu JD, Qian L (2016). Bmi1 Functions as a Critical Epigenetic Modulator during Early Phase of Direct Cardiac Reprogramming. Cell Stem Cell 18 (3), 382-95. Commentary: Herrer D and Benard A. Bmi1-Mediated Epigenetic Signature Acts as a Critical Barrier for Direct Reprogramming to Mature Cardiomyocytes. Stem Cell Investigation.
2015
8. Wang L, Liu Z, Yin C, Zhou Y, Liu J, Qian L (2015). Improved Generation of Induced Cardiomyocytes Using a Polycistronic Construct Expressing Optimal Ratio of Gata4, Mef2c and Tbx5. JoVE (Journal of Visualized Experiments) e53426-e53426.2014
7. Wang L*, Liu Z*, Yin C, Asfour H, Chen O, Li Y, Bursac N, Liu J, Qian L (2014). Stoichiometry of Gata4, Mef2c, and Tbx5 Influences the Efficiency and Quality of Induced Cardiac Myocyte Reprogramming. Circulation Research 116 (2), 237-244. *co-first author. Editorial’s pick of the issue. Editorial: Muraoka N, Ieda M. Stoichiometry of Transcription Factors Is Critical for Cardiac Reprogramming. Circulation Research.
6. Liu Z, F Zhao, He JJ (2014). Hepatitis C Virus (HCV) Interaction with Astrocytes: Non-Productive Infection and Induction of IL-18. Journal of Neurovirology 20 (3), 278-293
5. Liu Z, X Zhang, Q Yu, He JJ (2014). Exosome-Associated Hepatitis C Virus in Cell Cultures and Patient Plasma. Biochemical and biophysical research communications 455 (3), 218-22218.
2013
4. Liu Z, He JJ (2013). Cell-Cell Contact-Mediated Hepatitis C Virus (HCV) Transfer, Productive Infection and Replication and Its Requirement for HCV Receptors. Journal of Virology 87 (15), 8545-58.
3. Park IW, Ndjomou J, Wen Y, Liu Z, Ridgway ND, Kao CC, He JJ (2013). Inhibition of HCV Replication by Oxysterol-Binding Protein-Related Protein 4 (ORP4) through Interaction with HCV NS5B and Alteration of Lipid Droplet Formation. Plos One 8 (9), e75648.20.