Areas of Research
Cardiovascular PhysiologyThe Department of Physiology at MCW is working to understand fundamental principles of cardiovascular regulation and disease through a variety of...
Computational Biology and BioinformaticsThe department of Physiology's computational biology and bioinformatics research is about harnessing the power of the computer to understand biology...
Genetics and GenomicsThe department of Physiology is widely recognized as a leader in the development of genetic and genomic technologies and the application of these...
MetabolismThe department of Physiology's metabolism research emphasis is on the study of metabolic alterations in obesity and diabetes.
Molecular and Cellular PhysiologyThe department of Physiology's molecular and cellular physiology research focuses primarily on understanding basic signaling and ion transport systems...
NeurophysiologyThe department of Physiology's neurophysiology research focuses primarily on understanding the neural mechanisms involved in the control of breathing...
Renal PhysiologyThe department of Physiology's renal physiology research focuses primarily on the importance of renal blood flow and renal function in the regulation...
Respiratory PhysiologyThe department of Physiology's respiratory physiology research focuses primarily on understanding the neural mechanisms involved in the control of...
CVC researchers, working in one of the largest laboratory complexes in the U.S., have made significant accomplishments toward understanding and preventing diseases such as stroke, atherosclerosis, hypertension, and diabetes. The National Institutes of Health named the MCW CVC a Specialized Center for Research on Hypertension, one of only five in the U.S. Established in 1992, the Cardiovascular Center has more than 150 physicians and scientists from 23 departments at the Medical College of Wisconsin involved in multi-disciplinary research.
It has five major areas of focus: proteomics, genomics, computational biology, molecular imaging, and technology development, each with an emphasis on the application and transfer of technology. One of the major goals is to help create productive interfaces and synergy between the various academic departments at MCW, other universities both within Wisconsin and nationally, and with the biotechnology and pharmaceutical industries.
Founded in 1961, the General Clinical Research Center of the Medical College of Wisconsin is directed by Theodore Kotchen (Interim Director), and was one of the first National Institutes of Health-sponsored GCRC sites. The MCW GCRC includes an Adult Center located in the Lower Level Pavilion at Froedtert Hospital and an outpatient Pediatric and Transfusion Medicine Satellite located in Children's Wisconsin.
This PGA is focused on understanding the genetic basis of fundamental mechanistic pathways of the heart, lung, kidney, blood and vasculature through development of consomic rat panels and knockout models and physiological genomics, using environmental stressors. The dissemination of PhysGen data, animals, tissue slides, and bioinformatics resources to a large number of investigators is providing a valuable new tool to allow the linkage of genetic sequence information for the identification of gene function and the genetic basis of complex diseases.
Program Project Grants (PPGs)
The Program Project Grant in the department of Physiology is entitled Blood Pressure – Determinants & Controllers (funded by National Institutes of Health/National Heart Lung and Blood Institute grant 5 P01 HL29587-22, Allen J. Cowley, Jr., Principal Investigator). Ongoing for many years, this project was designed to explore the renal and vascular mechanisms involved in the long-term control of arterial pressure. We are currently focused on the interactions of the three important controllers of renal and peripheral vascular tone and arterial pressure: nitric oxide, 20-HETE and angiotensin II.
Part of what makes this program so strong is its position within a cluster of powerful, ongoing research programs supported by the within the department. Some of the most recent include:
Knock-out Rats for Physiological Genomics
(NIH/NHLBI grant 5 U01 HL66579-05, Howard J. Jacob, Principal Investigator)
The major goals of this project are to develop, phenotype, and distribute 56 consomic strains in the form of reciprocal chromosomal substitutions.
SCOR-Molecular Genetics of Hypertension
(NIH/NHLBI grant 5 P50 HL54998-09, Allen J. Cowley, Jr., Principal Investigator)
This project's goal is to determine the genetic loci and specific genes whose expression results in hypertension and in important phenotypic changes associated with hypertension.
P450 Eicosanoids and Altered Renal Function
(NIH/NHLBI grant 2 R01 HL36279-18, Richard J. Roman, Principal Investigator)
To study the role of the diminished production of 20-HETE in the thick ascending limb of Henle C1 - transport and in the development of hypertension in Dahl rats.
Physiological Genomics of Hypertensive Renal Disease
(NIH/NHLBI grant 1-R01 HL69321-02, Howard J. Jacob, Principal Investigator)
The major goal of this project is to define the genes on chromosome 1 responsible for the development of proteinuria and glomerular disease in Fawn-Hooded rats.
Mechanisms Regulating Nutritive Cerebral Blood Flow
(NIH/NHLBI grant 1-PO1 HL59996-05, David R. Harder, Principal Investigator)
Project 2: NO-20-HETE Interaction in the Control of Cerebral Vascular Tone
Core B: Biochemical and Molecular Core. This project was designed to study the role of 20-HETE in mediating the effects of nitric oxide on cerebral vascular tone.