Heather Himburg, PhD

Associate Professor, Radiation Oncology

Locations

Radiation Oncology

Contact Information

hhimburg@mcw.edu

Education

PhD, Biomedical Engineering, Duke University, Durham, NC, 2005
MS, Biomedical Engineering, Ohio State University, Columbus, OH, 2001
BS Physics, Miami University, Oxford, OH, 1998

Visit the Himburg Laboratory website

Biography

Training

Postdoctoral Fellow, Medicine, Cellular Therapy, Duke University, Durham, NC

Research Interests

Mitigation of hematopoietic acute radiation toxicity, role of the bone marrow microenvironment in regulating normal and malignant hematopoiesis, cancer stem cell biology

Mitigation of Multi-Organ Radiation Injury with ACE2 Agonist Diminazene Aceturate.

(Gasperetti T, Sharma GP, Frei AC, Pierce L, Veley D, Szalewski N, Narayanan J, Fish BL, Himburg HA.) Radiat Res. 2022 Oct 01;198(4):325-335 PMID: 35904437 PMCID: PMC9641750 SCOPUS ID: 2-s2.0-85139804264 07/30/2022
Chronic stress promotes an immunologic inflammatory state and head and neck cancer growth in a humanized murine model.

(Zenga J, Awan MJ, Frei A, Petrie E, Sharma GP, Shreenivas A, Shukla M, Himburg HA.) Head Neck. 2022 Jun;44(6):1324-1334 PMID: 35261119 PMCID: PMC9081149 SCOPUS ID: 2-s2.0-85125920861 03/10/2022
Pharmacologic ACE-Inhibition Mitigates Radiation-Induced Pneumonitis by Suppressing ACE-Expressing Lung Myeloid Cells.

(Sharma GP, Fish BL, Frei AC, Narayanan J, Gasperetti T, Scholler D, Pierce L, Szalewski N, Blue N, Medhora M, Himburg HA.) Int J Radiat Oncol Biol Phys. 2022 May 01;113(1):177-191 PMID: 35093482 PMCID: PMC9018504 SCOPUS ID: 2-s2.0-85125928392 01/31/2022
Neuropilin 1 regulates bone marrow vascular regeneration and hematopoietic reconstitution.

(Termini CM, Pang A, Fang T, Roos M, Chang VY, Zhang Y, Setiawan NJ, Signaevskaia L, Li M, Kim MM, Tabibi O, Lin PK, Sasine JP, Chatterjee A, Murali R, Himburg HA, Chute JP.) Nat Commun. 2021 Nov 30;12(1):6990 PMID: 34848712 PMCID: PMC8635308 SCOPUS ID: 2-s2.0-85120176028 12/02/2021
Rat Models of Partial-body Irradiation with Bone Marrow-sparing (Leg-out PBI) Designed for FDA Approval of Countermeasures for Mitigation of Acute and Delayed Injuries by Radiation.

(Fish BL, MacVittie TJ, Gao F, Narayanan J, Gasperetti T, Scholler D, Sheinin Y, Himburg HA, Hart B, Medhora M.) Health Phys. 2021 Oct 01;121(4):419-433 PMID: 34546222 PMCID: PMC8577554 SCOPUS ID: 2-s2.0-85117425987 09/22/2021
Brain-derived neurotrophic factor promotes immune reconstitution following radiation injury via activation of bone marrow mesenchymal stem cells.

(Sharma GP, Frei AC, Narayanan J, Gasperetti T, Veley D, Amjad A, Albano K, Fish BL, Himburg HA.) PLoS One. 2021;16(10):e0259042 PMID: 34695155 PMCID: PMC8544859 SCOPUS ID: 2-s2.0-85117930366 10/26/2021
Epidermal growth factor receptor-dependent DNA repair promotes murine and human hematopoietic regeneration.

(Fang T, Zhang Y, Chang VY, Roos M, Termini CM, Signaevskaia L, Quarmyne M, Lin PK, Pang A, Kan J, Yan X, Javier A, Pohl K, Zhao L, Scott P, Himburg HA, Chute JP.) Blood. 2020 Jul 23;136(4):441-454 PMID: 32369572 PMCID: PMC7378456 SCOPUS ID: 2-s2.0-85088499146 05/06/2020
Chronic myeloid leukemia stem cells require cell-autonomous pleiotrophin signaling.

(Himburg HA, Roos M, Fang T, Zhang Y, Termini CM, Schlussel L, Kim M, Pang A, Kan J, Zhao L, Suh H, Sasine JP, Sapparapu G, Bowers PM, Schiller G, Chute JP.) J Clin Invest. 2020 Jan 02;130(1):315-328 PMID: 31613796 PMCID: PMC6934217 SCOPUS ID: 2-s2.0-85077404546 10/16/2019
PTPσ inhibitors promote hematopoietic stem cell regeneration.

(Zhang Y, Roos M, Himburg H, Termini CM, Quarmyne M, Li M, Zhao L, Kan J, Fang T, Yan X, Pohl K, Diers E, Jin Gim H, Damoiseaux R, Whitelegge J, McBride W, Jung ME, Chute JP.) Nat Commun. 2019 Aug 14;10(1):3667 PMID: 31413255 PMCID: PMC6694155 SCOPUS ID: 2-s2.0-85070740613 08/16/2019
Dickkopf-1 Treatment Stimulates Hematopoietic Regenerative Function in Infused Endothelial Progenitor Cells.

(Kim MM, Schlussel L, Zhao L, Himburg HA.) Radiat Res. 2019 Jul;192(1):53-62 PMID: 31081743 PMCID: PMC6668624 SCOPUS ID: 2-s2.0-85068359875 05/14/2019
Distinct Bone Marrow Sources of Pleiotrophin Control Hematopoietic Stem Cell Maintenance and Regeneration.

(Himburg HA, Termini CM, Schlussel L, Kan J, Li M, Zhao L, Fang T, Sasine JP, Chang VY, Chute JP.) Cell Stem Cell. 2018 Sep 06;23(3):370-381.e5 PMID: 30100167 PMCID: PMC6482945 SCOPUS ID: 2-s2.0-85056484773 08/14/2018
Wild-type Kras expands and exhausts hematopoietic stem cells.

(Sasine JP, Himburg HA, Termini CM, Roos M, Tran E, Zhao L, Kan J, Li M, Zhang Y, de Barros SC, Rao DS, Counter CM, Chute JP.) JCI Insight. 2018 Jun 07;3(11) PMID: 29875320 PMCID: PMC6124423 SCOPUS ID: 2-s2.0-85056627323 06/08/2018