Raul A. Urrutia, MD

Publications

• Cancer-associated polybromo-1 bromodomain 4 missense variants variably impact bromodomain ligand binding and cell growth suppression.

  (Bursch KL, Goetz CJ, Jiao G, Nuñez R, Olp MD, Dhiman A, Khurana M, Zimmermann MT, Urrutia RA, Dykhuizen EC, Smith BC.) J Biol Chem. 2024 Mar 07;300(4):107146 PMID: 38460939 PMCID: PMC11002309 SCOPUS ID: 2-s2.0-85189184192 03/10/2024

• Enhancing prognostic power in multiple myeloma using a plasma cell signature derived from single-cell RNA sequencing.

  (Li JR, Arsang-Jang S, Cheng Y, Sun F, D'Souza A, Dhakal B, Hari P, Huang Q, Auer P, Li Y, Urrutia R, Zhan F, Shaughnessy JD Jr, Janz S, Dong J, Cheng C.) Blood Cancer J. 2024 Mar 06;14(1):38 PMID: 38443358 PMCID: PMC10915134 SCOPUS ID: 2-s2.0-85186929795 03/06/2024

• Targeting NUPR1-dependent stress granules formation to induce synthetic lethality in KrasG12D-driven tumors.

  (Santofimia-Castaño P, Fraunhoffer N, Liu X, Bessone IF, di Magliano MP, Audebert S, Camoin L, Estaras M, Brenière M, Modesti M, Lomberk G, Urrutia R, Soubeyran P, Neira JL, Iovanna J.) EMBO Mol Med. 2024 Mar;16(3):475-505 PMID: 38360999 PMCID: PMC10940650 SCOPUS ID: 2-s2.0-85185320484 02/16/2024

• Verteporfin induces lipid peroxidation and ferroptosis in pancreatic cancer cells.

  (Zhou W, Lim A, Elmadbouh OHM, Edderkaoui M, Osipov A, Mathison AJ, Urrutia R, Liu T, Wang Q, Pandol SJ.) Free Radic Biol Med. 2024 Feb 20;212:493-504 PMID: 38184120 PMCID: PMC10906657 SCOPUS ID: 2-s2.0-85182384342 01/07/2024

• Identification of novel loci for multiple myeloma when comparing with its precursor condition monoclonal gammopathy of unknown significance.

  (Buradagunta CS, Arsang-Jang S, Massat B, Thapa B, Patek V, D'Souza A, Auer P, Urrutia R, Janz S, Dhakal B, Hari P, Dong J.) Leukemia. 2024 Feb;38(2):383-385 PMID: 37919604 SCOPUS ID: 2-s2.0-85175540732 11/03/2023

• An EMR-Based Approach to Determine Frequency, Prescribing Pattern, and Characteristics of Patients Receiving Drugs with Pharmacogenomic Guidelines.

  (MacKinnon GE 3rd, Mills M, Stoddard A, Urrutia RA, Broeckel U.) Pharmacy (Basel). 2023 Nov 17;11(6) PMID: 37987388 PMCID: PMC10661282 11/21/2023

• Writers and readers of H3K9me2 form distinct protein networks during the cell cycle that include candidates for H3K9 mimicry.

  (Pollin G, De Assuncao TM, Doria Jorge S, Chi YI, Charlesworth MC, Madden B, Iovanna J, Zimmermann MT, Urrutia R, Lomberk G.) Biosci Rep. 2023 Oct 31;43(10) PMID: 37782747 PMCID: PMC10611923 SCOPUS ID: 2-s2.0-85175273435 10/02/2023

• Advanced computational analysis of CD40LG variants in atypical X-linked hyper-IgM syndrome.

  (Pazhanisamy A, Jorge SD, Zimmermann MT, Kitcharoensakkul M, Abdalgani M, Khojah A, Victor C, Rueda C, Urrutia R, Abraham RS.) Clin Immunol. 2023 Aug;253:109692 PMID: 37433422 SCOPUS ID: 2-s2.0-85164736502 07/12/2023

• KLF5 and p53 comprise an incoherent feed-forward loop directing cell-fate decisions following stress.

  (Yang Y, Bhargava D, Chen X, Zhou T, Dursuk G, Jiang W, Wang J, Zong Z, Katz SI, Lomberk GA, Urrutia RA, Katz JP.) Cell Death Dis. 2023 May 02;14(5):299 PMID: 37130837 PMCID: PMC10154356 SCOPUS ID: 2-s2.0-85157983058 05/03/2023

• Prognostic landscape of mitochondrial genome in myelodysplastic syndrome after stem-cell transplantation.

  (Dong J, Buradagunta CS, Zhang T, Spellman S, Bolon YT, DeZern AE, Gadalla SM, Deeg HJ, Nazha A, Cutler C, Cheng C, Urrutia R, Auer P, Saber W.) J Hematol Oncol. 2023 Mar 10;16(1):21 PMID: 36899395 PMCID: PMC9999628 SCOPUS ID: 2-s2.0-85149930611 03/11/2023

• Deep computational phenotyping of genomic variants impacting the SET domain of KMT2C reveal molecular mechanisms for their dysfunction.

  (Jorge SD, Chi YI, Mazaba JL, Haque N, Wagenknecht J, Smith BC, Volkman BF, Mathison AJ, Lomberk G, Zimmermann MT, Urrutia R.) Front Genet. 2023;14:1291307 PMID: 38090150 PMCID: PMC10715303 SCOPUS ID: 2-s2.0-85179362461 12/13/2023

• Priming therapy by targeting enhancer-initiated pathways in patient-derived pancreatic cancer cells

  (Fraunhoffer NA, Moreno Vega AI, Abuelafia AM, Morvan M, Lebarbier E, Mary-Huard T, Zimmermann M, Lomberk G, Urrutia R, Dusetti N, Blum Y, Nicolle R, Iovanna J.) eBioMedicine. June 2023;92 SCOPUS ID: 2-s2.0-85154565512 06/01/2023