Ze Zheng, MBBS, PhD
- Health Research Center
Versiti Blood Research Institute
PhD, The Center for Molecular Medicine and Genetics, Wayne State University
Postdoctoral Fellowship, Division of Molecular Medicine, Columbia University Medical Center
Dr. Ze Zheng is an Assistant Professor of Medicine at the Medical College of Wisconsin, and an Associate Investigator at the Versiti Blood Research Institute, where her research laboratory is located. She received her MBBS in clinical medicine from Jiamusi University, and her PhD in molecular biology and genetics of liver metabolism from Wayne State University (mentor Kezhong Zhang, PhD). She completed her postdoctoral fellowship in cardiometabolism research at Columbia University Medical Center (mentor Ira Tabas, MD, PhD). She has published in leading journals on a broad range of topics, including fibrinolysis, thrombosis, lipid and glucose metabolism, atherosclerosis, circadian rhythm, nonalcoholic steatohepatitis (NASH), and air pollution-associated liver injuries.
Her recent studies focus on the role of hepatocyte-derived fibrinolytic enzymes in obesity-associated atherosclerosis, thrombosis and hemostasis. Her research has been funded by a Berrie Scholar Award from Russell Berrie Foundation, an NIH T32 training grant, an ASH Scholar Award from American Society of Hematology, a Career Development Award from American Heart Association, a Career Development Award from National Hemophilia Foundation, a Cullen Scholar Award from Steve Cullen Run Foundation through MCW Cardiovascular Center, a Joan Gill Pilot Award from the Versiti Blood Center of Wisconsin, Startup Fund from MCW and Versiti, and a recently awarded R01 from NHLBI. She serves as a member of the American Society of Hematology Task Force for PhD Careers, and the International Society of Thrombosis and Haemostasis (ISTH) Ethics Committee and the Co-Chair of ISTH Fibrinolysis Subcommittee.
- Associate Investigator, Versiti Blood Research Institute, Blood Center of Wisconsin
- Member, Cardiovascular Center, Medical College of Wisconsin
- Assistant Professor, Department of Physiology, Medical College of Wisconsin
- Member, Task Force for PhD Careers, American Society of Hematology
- Co-chair, Fibrinolysis Subcommittee, International Society on Thrombosis and Haemostasias (ISTH)
- Member, Ethics Committee, International Society on Thrombosis and Haemostasias (ISTH)
- Member, Conflict of Interest Policy and Process Focus Group, International Society on Thrombosis and Haemostasis (ISTH)
- Board Member, Fredrickson Lipid Research Conference Board of Directors
- Co-chair, Planning Committee for 2024 Fredrickson Lipid Research Conference to be held in Milwaukee, WI
- Member, Planning Committee Member, American Heart Association Committee for Scientific Sessions Programming, representing the Council on Arteriosclerosis, Thrombosis and Vascular Biology (ATVB)
- Member, Interdisciplinary Doctoral Program in Biomedical Sciences (IDP) Recruiting Committee, Medical College of Wisconsin
- Member, Seminar Series Committee, Versiti Blood Research Institute
- Circadian Rhythm
- Fatty Liver
- Liver Cirrhosis
- Metabolic Syndrome
- A new link between fibrinolytic proteins and dyslipidemia
- Fibrinolysis in hemophilia
- Fibrinolysis in COVID-19
- Circadian regulation of basal fibrinolysis and the morning onset of thrombotic events
- The role of hepatocyte tPA in liver injuries
Developing and improving the ethical framework for the ISTH.
(Zheng Z, Riva N, Scarlatescu E, de Moerloose P, Ariëns R, Amigo MC, ISTH Ethics Committee.) J Thromb Haemost. 2022 Aug;20(8):1753-1754 PMID: 35859283 07/22/2022
Impact of COVID-19 on Hematology-Oncology Trainees: A Quantitative and Qualitative Assessment.
(Durani U, Major A, Velazquez AI, May J, Nelson M, Zheng Z, Hall AG, Alam ST, Reynolds R, Thompson JC, Kumbamu A, Das DG, Murphy MC, Henry E, Lee AI, Marshall AL, Wun T, Weeks LD.) JCO Oncol Pract. 2022 Apr;18(4):e586-e599 PMID: 34990292 PMCID: PMC9014488 SCOPUS ID: 2-s2.0-85128487414 01/07/2022
Deficiency of macrophage PHACTR1 impairs efferocytosis and promotes atherosclerotic plaque necrosis.
(Kasikara C, Schilperoort M, Gerlach B, Xue C, Wang X, Zheng Z, Kuriakose G, Dorweiler B, Zhang H, Fredman G, Saleheen D, Reilly MP, Tabas I.) J Clin Invest. 2021 Apr 15;131(8) PMID: 33630758 PMCID: PMC8262505 SCOPUS ID: 2-s2.0-85104174793 02/26/2021
Hypertriglyceridemia during hospitalization independently associates with mortality in patients with COVID-19.
(Dai W, Lund H, Chen Y, Zhang J, Osinski K, Jones SZ, Kreuziger LB, López JA, Benjamin IJ, Silverstein RL, Zheng Z.) J Clin Lipidol. 2021;15(5):724-731 PMID: 34470719 PMCID: PMC8353976 SCOPUS ID: 2-s2.0-85114047849 09/03/2021
Interacting hepatic PAI-1/tPA gene regulatory pathways influence impaired fibrinolysis severity in obesity.
(Zheng Z, Nakamura K, Gershbaum S, Wang X, Thomas S, Bessler M, Schrope B, Krikhely A, Liu RM, Ozcan L, López JA, Tabas I.) J Clin Invest. 2020 Aug 03;130(8):4348-4359 PMID: 32657780 PMCID: PMC7410057 SCOPUS ID: 2-s2.0-85089125237 07/14/2020
Cholesterol Stabilizes TAZ in Hepatocytes to Promote Experimental Non-alcoholic Steatohepatitis.
(Wang X, Cai B, Yang X, Sonubi OO, Zheng Z, Ramakrishnan R, Shi H, Valenti L, Pajvani UB, Sandhu J, Infante RE, Radhakrishnan A, Covey DF, Guan KL, Buck J, Levin LR, Tontonoz P, Schwabe RF, Tabas I.) Cell Metab. 2020 May 05;31(5):969-986.e7 PMID: 32259482 PMCID: PMC7313619 SCOPUS ID: 2-s2.0-85083861208 04/08/2020
Macrophage Metabolism of Apoptotic Cell-Derived Arginine Promotes Continual Efferocytosis and Resolution of Injury.
(Yurdagul A Jr, Subramanian M, Wang X, Crown SB, Ilkayeva OR, Darville L, Kolluru GK, Rymond CC, Gerlach BD, Zheng Z, Kuriakose G, Kevil CG, Koomen JM, Cleveland JL, Muoio DM, Tabas I.) Cell Metab. 2020 Mar 03;31(3):518-533.e10 PMID: 32004476 PMCID: PMC7173557 SCOPUS ID: 2-s2.0-85080068507 02/01/2020
Macrophage MerTK Promotes Liver Fibrosis in Nonalcoholic Steatohepatitis.
(Cai B, Dongiovanni P, Corey KE, Wang X, Shmarakov IO, Zheng Z, Kasikara C, Davra V, Meroni M, Chung RT, Rothlin CV, Schwabe RF, Blaner WS, Birge RB, Valenti L, Tabas I.) Cell Metab. 2020 Feb 04;31(2):406-421.e7 PMID: 31839486 PMCID: PMC7004886 SCOPUS ID: 2-s2.0-85078479595 12/17/2019
An ATF6-tPA pathway in hepatocytes contributes to systemic fibrinolysis and is repressed by DACH1.
(Zheng Z, Nayak L, Wang W, Yurdagul A Jr, Wang X, Cai B, Lapping S, Ozcan L, Ramakrishnan R, Pestell RG, Jain MK, Tabas I.) Blood. 2019 Feb 14;133(7):743-753 PMID: 30504459 PMCID: PMC6376283 SCOPUS ID: 2-s2.0-85061475922 12/07/2018
Hepatocyte-secreted DPP4 in obesity promotes adipose inflammation and insulin resistance.
(Ghorpade DS, Ozcan L, Zheng Z, Nicoloro SM, Shen Y, Chen E, Blüher M, Czech MP, Tabas I.) Nature. 2018 Mar 29;555(7698):673-677 PMID: 29562231 PMCID: PMC6021131 SCOPUS ID: 2-s2.0-85044788933 03/22/2018
Inhalation Exposure to PM2.5 Counteracts Hepatic Steatosis in Mice Fed High-fat Diet by Stimulating Hepatic Autophagy.
(Qiu Y, Zheng Z, Kim H, Yang Z, Zhang G, Shi X, Sun F, Peng C, Ding Y, Wang A, Chen LC, Rajagopalan S, Sun Q, Zhang K.) Sci Rep. 2017 Nov 24;7(1):16286 PMID: 29176715 PMCID: PMC5701159 SCOPUS ID: 2-s2.0-85034992166 11/28/2017
Interaction between stress responses and circadian metabolism in metabolic disease.
(Yang Z, Kim H, Ali A, Zheng Z, Zhang K.) Liver Res. 2017 Sep;1(3):156-162 PMID: 29430321 PMCID: PMC5805151 SCOPUS ID: 2-s2.0-85051645629 02/13/2018