Ze Zheng, MBBS, PhD
Assistant Professor
Locations
- Versiti Blood Research Institute
Contact Information
Education
PhD, The Center for Molecular Medicine and Genetics, Wayne State University
Biography
Secondary Appointments
- Assistant Investigator, Versiti Blood Research Institute, Blood Center of Wisconsin
- Member, Cardiovascular Center, Medical College of Wisconsin
Leadership Positions
External
- Co-chair for the Fibrinolysis Subcommittee, International Society on Thrombosis and Haemostasias (ISTH)
- Member, Ethics Committee, International Society on Thrombosis and Haemostasias (ISTH)
- Member, Task Force for PhD Careers, American Society of Hematology
Research Experience
- Atherosclerosis
- Circadian Rhythm
- Fatty Liver
- Fibrinolysis
- Lipoproteins
- Liver Cirrhosis
- Metabolic Syndrome
- Obesity
- Thrombosis
Research Interests
Laboratory Studies
- A new link between reduced fibrinolysis and dyslipidemia
- Circadian regulation of basal fibrinolysis and the morning onset of thrombotic events
- The role of hepatocyte tPA and liver injuries
- Increased fibrinolysis in hemophilia
- A timely study of fibrinolysis in COVID-19
Publications
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Deficiency of macrophage PHACTR1 impairs efferocytosis and promotes atherosclerotic plaque necrosis.
(Kasikara C, Schilperoort M, Gerlach B, Xue C, Wang X, Zheng Z, Kuriakose G, Dorweiler B, Zhang H, Fredman G, Saleheen D, Reilly MP, Tabas I.) J Clin Invest. 2021 Apr 15;131(8) PMID: 33630758 02/26/2021
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(Zheng Z, Nakamura K, Gershbaum S, Wang X, Thomas S, Bessler M, Schrope B, Krikhely A, Liu RM, Ozcan L, López JA, Tabas I.) J Clin Invest. 2020 08 03;130(8):4348-4359 PMID: 32657780 PMCID: PMC7410057 SCOPUS ID: 2-s2.0-85089125237 07/14/2020
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Cholesterol Stabilizes TAZ in Hepatocytes to Promote Experimental Non-alcoholic Steatohepatitis.
(Wang X, Cai B, Yang X, Sonubi OO, Zheng Z, Ramakrishnan R, Shi H, Valenti L, Pajvani UB, Sandhu J, Infante RE, Radhakrishnan A, Covey DF, Guan KL, Buck J, Levin LR, Tontonoz P, Schwabe RF, Tabas I.) Cell Metab. 2020 05 05;31(5):969-986.e7 PMID: 32259482 PMCID: PMC7313619 SCOPUS ID: 2-s2.0-85083861208 04/08/2020
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(Yurdagul A Jr, Subramanian M, Wang X, Crown SB, Ilkayeva OR, Darville L, Kolluru GK, Rymond CC, Gerlach BD, Zheng Z, Kuriakose G, Kevil CG, Koomen JM, Cleveland JL, Muoio DM, Tabas I.) Cell Metab. 2020 03 03;31(3):518-533.e10 PMID: 32004476 PMCID: PMC7173557 SCOPUS ID: 2-s2.0-85080068507 02/01/2020
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Macrophage MerTK Promotes Liver Fibrosis in Nonalcoholic Steatohepatitis.
(Cai B, Dongiovanni P, Corey KE, Wang X, Shmarakov IO, Zheng Z, Kasikara C, Davra V, Meroni M, Chung RT, Rothlin CV, Schwabe RF, Blaner WS, Birge RB, Valenti L, Tabas I.) Cell Metab. 2020 02 04;31(2):406-421.e7 PMID: 31839486 PMCID: PMC7004886 SCOPUS ID: 2-s2.0-85078479595 12/17/2019
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An ATF6-tPA pathway in hepatocytes contributes to systemic fibrinolysis and is repressed by DACH1.
(Zheng Z, Nayak L, Wang W, Yurdagul A Jr, Wang X, Cai B, Lapping S, Ozcan L, Ramakrishnan R, Pestell RG, Jain MK, Tabas I.) Blood. 2019 02 14;133(7):743-753 PMID: 30504459 PMCID: PMC6376283 SCOPUS ID: 2-s2.0-85061475922 12/07/2018
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Hepatocyte-secreted DPP4 in obesity promotes adipose inflammation and insulin resistance.
(Ghorpade DS, Ozcan L, Zheng Z, Nicoloro SM, Shen Y, Chen E, Blüher M, Czech MP, Tabas I.) Nature. 2018 03 29;555(7698):673-677 PMID: 29562231 PMCID: PMC6021131 SCOPUS ID: 2-s2.0-85044788933 03/22/2018
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(Qiu Y, Zheng Z, Kim H, Yang Z, Zhang G, Shi X, Sun F, Peng C, Ding Y, Wang A, Chen LC, Rajagopalan S, Sun Q, Zhang K.) Sci Rep. 2017 11 24;7(1):16286 PMID: 29176715 PMCID: PMC5701159 SCOPUS ID: 2-s2.0-85034992166 11/28/2017
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(Doran AC, Ozcan L, Cai B, Zheng Z, Fredman G, Rymond CC, Dorweiler B, Sluimer JC, Hsieh J, Kuriakose G, Tall AR, Tabas I.) J Clin Invest. 2017 Nov 01;127(11):4075-4089 PMID: 28972541 PMCID: PMC5663361 SCOPUS ID: 2-s2.0-85032982234 10/04/2017
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Interaction between stress responses and circadian metabolism in metabolic disease.
(Yang Z, Kim H, Ali A, Zheng Z, Zhang K.) Liver Res. 2017 Sep;1(3):156-162 PMID: 29430321 PMCID: PMC5805151 SCOPUS ID: 2-s2.0-85051645629 02/13/2018
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(Kim H, Zheng Z, Walker PD, Kapatos G, Zhang K.) Mol Cell Biol. 2017 07 15;37(14) PMID: 28461393 PMCID: PMC5492176 SCOPUS ID: 2-s2.0-85021826450 05/04/2017
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Hepatocyte TAZ/WWTR1 Promotes Inflammation and Fibrosis in Nonalcoholic Steatohepatitis.
(Wang X, Zheng Z, Caviglia JM, Corey KE, Herfel TM, Cai B, Masia R, Chung RT, Lefkowitch JH, Schwabe RF, Tabas I.) Cell Metab. 2016 12 13;24(6):848-862 PMID: 28068223 PMCID: PMC5226184 SCOPUS ID: 2-s2.0-85003945921 01/10/2017