Zheng Laboratory
Lab Director | Ze Zheng, MBBS, PhD
- Assistant Professor, Division of Endocrinology and Molecular Medicine, Department of Medicine (primary), Medical College of Wisconsin
- Assistant Associate Investigator, Versiti Blood Research Institute, Blood Center of Wisconsin
- Member, Cardiovascular Center, Medical College of Wisconsin
- Assistant Professor, Department of Physiology (secondary), Medical College of Wisconsin
Research Areas
Our laboratory studies the interactions between metabolism and blood clot lysis. Fibrinolysis, the primary mechanism that dissolves a blood clot, is initiated by a serine protease tissue-type plasminogen activator (tPA). Our previous study discussed a novel source and regulation of endogenous basal plasma tPA derived from hepatocytes, which is important for fibrinolysis when a vessel injury occurs. The tPA activity is inhibited primarily by the serpin plasminogen activator inhibitor 1 (PAI-1). A balance between tPA and PAI-1 in plasma is essential for preventing excessive clotting. Our recent study revealed the mechanism of how hepatocytes sense metabolic stresses and imbalance the production of tPA and PAI-1, influencing the degree of impaired fibrinolysis in obesity.
The goal of our laboratory is to understand the role of hepatocyte-derived tPA and basal fibrinolysis in hemostasis, and to develop diagnostic/ preventive/ therapeutic strategies that can be used to combat atherosclerosis, thrombosis, and bleeding disorders. Specific areas of research interests include: 1) a new link between reduced fibrinolysis and dyslipidemia, 2) circadian regulation of basal fibrinolysis and the morning onset of thrombotic events, 3) the role of hepatocyte tPA and liver injuries, 4) increased fibrinolysis in hemophilia, and 5) a timely study of fibrinolysis in COVID-19.
Current Members
Hayley Lund, BS
Lab Manager
Wen Dai, MD
Postdoctoral Fellow
Hortense Triniac, PhD
Postdoctoral Fellow
Ziyu Zhang, MD
Postdoctoral Fellow
Marjorie Kipp, BS
Technician
Mark Castleberry, PhD
Research Scientist I
Mindy Kim, BA
MSTP Student
Maya Rodriguez
Student Research Assistant
Research in the Ze Zheng Laboratory
Recent Publications
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Tale of two systems: the intertwining duality of fibrinolysis and lipoprotein metabolism.
(Dai W, Castleberry M, Zheng Z.) J Thromb Haemost. 2023 Oct;21(10):2679-2696 PMID: 37579878 PMCID: PMC10599797 SCOPUS ID: 2-s2.0-85171457835 08/15/2023
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Intracellular tPA-PAI-1 interaction determines VLDL assembly in hepatocytes.
(Dai W, Zhang H, Lund H, Zhang Z, Castleberry M, Rodriguez M, Kuriakose G, Gupta S, Lewandowska M, Powers HR, Valmiki S, Zhu J, Shapiro AD, Hussain MM, López JA, Sorci-Thomas MG, Silverstein RL, Ginsberg HN, Sahoo D, Tabas I, Zheng Z.) Science. 2023 Sep;381(6661):eadh5207 PMID: 37651538 PMCID: PMC10697821 SCOPUS ID: 2-s2.0-85169348601 08/31/2023
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(Zhang Z, Dai W, Zhu W, Rodriguez M, Lund H, Xia Y, Chen Y, Rau M, Schneider EA, Graham MB, Jobe S, Wang D, Cui W, Wen R, Whiteheart SW, Wood JP, Silverstein R, Berger JS, Kreuziger LB, Barrett TJ, Zheng Z.) Res Pract Thromb Haemost. 2023 Aug;7(6):102164 PMID: 37680312 PMCID: PMC10480648 09/08/2023
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Illustrated State-of-the-Art Capsules of the ISTH 2023 Congress.
(Kahn SR, Arnold DM, Casari C, Desch KC, Devreese KMJ, Favaloro EJ, Gaertner F, Gouw SC, Gresele P, Griffioen AW, Heger L, Kini RM, Kohli S, Leader A, Lisman T, Lordkipanidzé M, Mullins E, Okoye HC, Rosovsky RP, Salles-Crawley II, Selby R, Sholzberg M, Stegner D, Violi F, Weyand AC, Williams S, Zheng Z.) Res Pract Thromb Haemost. 2023 May;7(4):100193 PMID: 37538494 PMCID: PMC10394567 08/04/2023
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(Zheng Z, Mukhametova L, Boffa MB, Moore EE, Wolberg AS, Urano T, Kim PY.) J Thromb Haemost. 2023 Apr;21(4):1043-1054 PMID: 36759279 PMCID: PMC10109242 SCOPUS ID: 2-s2.0-85150846431 02/10/2023
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(Puzyrenko A, Jacobs ER, Padilla N, Devine A, Aljadah M, Gantner BN, Pan AY, Lai S, Dai Q, Rubenstein JC, North PE, Simpson PM, Willoughby RE, O'Meara CC, Flinn MA, Lough JW, Ibrahim EH, Zheng Z, Sun Y, Felix J, Hunt BC, Ross G, Rui H, Benjamin IJ.) J Am Heart Assoc. 2023 Feb 21;12(4):e027990 PMID: 36789856 PMCID: PMC10111490 SCOPUS ID: 2-s2.0-85148479620 02/16/2023
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(Furon J, Yetim M, Pouettre E, Martinez de Lizarrondo S, Maubert E, Hommet Y, Lebouvier L, Zheng Z, Ali C, Vivien D.) Fluids Barriers CNS. 2023 Feb 03;20(1):11 PMID: 36737775 PMCID: PMC9896721 SCOPUS ID: 2-s2.0-85147445875 02/05/2023
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Editorial: Women in cardiovascular therapeutics.
(Yin L, Zhou T, Zheng Z, Long X, Qiu H, Lu HS.) Front Cardiovasc Med. 2023;10:1183427 PMID: 37234374 PMCID: PMC10207329 05/26/2023
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(Shi H, Wang X, Li F, Gerlach BD, Yurdagul A Jr, Moore MP, Zeldin S, Zhang H, Cai B, Zheng Z, Valenti L, Tabas I.) Sci Transl Med. 2022 Nov 23;14(672):eabp8309 PMID: 36417485 PMCID: PMC10199725 SCOPUS ID: 2-s2.0-85142940071 11/24/2022
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Na/K-ATPase suppresses LPS-induced pro-inflammatory signaling through Lyn.
(Zhang J, Chang J, Beg MA, Huang W, Zhao Y, Dai W, Wu X, Cui W, Pillai SS, Lakhani HV, Sodhi K, Shapiro JI, Sahoo D, Zheng Z, Silverstein RL, Chen Y.) iScience. 2022 Sep 16;25(9):104963 PMID: 36072548 PMCID: PMC9442361 SCOPUS ID: 2-s2.0-85137074779 09/09/2022
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(Rodriguez M, Dai W, Lund H, Osinski K, Zhang Z, Silverstein R, Zheng Z.) Best Pract Res Clin Haematol. 2022 Sep;35(3):101386 PMID: 36494155 PMCID: PMC9527214 SCOPUS ID: 2-s2.0-85140078248 12/10/2022
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COVID-19: A hematological perspective.
(Nayak L, Zheng Z.) Best Pract Res Clin Haematol. 2022 Sep;35(3):101412 PMID: 36494151 PMCID: PMC9633637 SCOPUS ID: 2-s2.0-85141789848 12/10/2022