Andreas Beyer Lab
Andreas M. Beyer, PhD
Associate Professor, Department of Medicine and Physiology
Curriculum Vitae (PDF)
Twitter: @BeyerLab
abeyer@mcw.edu
Lab Projects
Current Members
Laura Norwood Toro
Research Scientist I
lnorwood@mcw.edu
Laura Norwood Toro is a Research Scientist I in the Andreas Beyer Lab. Her primary responsibility is to explore the effect of chemotherapy on cardiovascular outcomes in coronary circulation and vascular endothelium. One focus of her studies is to investigate the functions of telomerase in the nucleus versus the mitochondria. Her background is in cell biology and molecular biology.
Bill Hughes, PhD
Postdoctoral Fellow
whughes@mcw.edu
Bill Hughes is a postdoctoral fellow in the Beyer/Gutterman Lab. Prior to starting at MCW he received his PhD from the University of Iowa. His research interests are human integrative cardiovascular physiology and vascular biology in health, aging, and chronic disease. In collaboration with Dr. Beyer and Dr. Gutterman, he is studying the cross-talk between autophagy, a basic cellular recycling process, and telomerase within the context of microvascular function in coronary artery disease (CAD). Flow-mediated dilation is predominately mediated by nitric oxide (NO) in healthy populations, but this mediator switches to hydrogen peroxide (H2O2) with CAD. Autophagy has recently been demonstrated to be sensitive to shear stress, and preliminary data from our lab indicates that inhibition of autophagy switches the mediator of FMD from NO to H2O2 in non-CAD vessels, while activation of autophagy in CAD vessels recapitulates a healthy phenotype (NO-mediated). Additionally, our lab has also demonstrated that upregulation of telomerase reduces mitochondrial release of H2O2 in vessels with CAD, restoring NO-mediated FMD. In this context, it is possible that there is significant crosstalk between pathways, with telomerase upstream of autophagy. Collectively, as numerous chronic diseases modulate both telomerase activity and autophagy it remains unknown how these two processes are inherently linked in the context of CAD.
Shelby Hader
Research Technologist II
shader@mcw.edu
Shelby Hader is a Research Technologist II in the Beyer/Gutterman Lab. Prior to starting at MCW she received her BA from the Lawrence University. Her primary goal is to analyze the vascular reactivity of human coronary arterioles and adipose micro vessels within different healthy and diseased patients. Some of her projects include: the cardiotoxicity of chemotherapy upon the microvasculature along with measuring the differences between fission and fusion of mitochondria in human arterioles. Additionally, Shelby provides research support for multiple projects in the lab via imaging, dissection of discarded tissue, and rat/mice colony maintenance.
Janée Terwoord
Postdoctoral fellow
Janée Terwoord is a postdoctoral fellow working with Drs Beyer and Gutterman to investigate human microvascular physiology. Prior to joining the team at MCW, Janée earned her PhD in a clinical laboratory focused on the integrative control of blood flow distribution in humans. Her research interests include the signaling mechanisms that regulate vascular tone. Currently, Janée is working to characterize the cellular mechanisms by which cancer therapeutic drugs damage the microvasculature. She is studying how mitochondrial damage induced by these drugs contributes to endothelial dysfunction, which will inform new approaches to mitigate the detrimental cardiovascular effects of anti-cancer therapy.
Erin Birch
Research Technologist I
ebirch@mcw.edu
Erin Birch is a research technologist in Dr. Beyer and Dr. Zhang’s labs. Erin has experience researching autoimmune diseases, chronic kidney disease, and cardiovascular disease. She is working with Dr. Beyer’s lab to provide support with several projects. Erin also contributes to the analysis of microvascular function in patients with coronary artery disease, COVID-19, and healthy patients. In her free time, Erin enjoys traveling and adventuring in the Rocky Mountains.
Lukas Brandt
Research Assistant
lbrandt@mcw.edu
Lukas Brandt is a graduate student in Dr. Beyer's lab. Prior to starting at MCW's physiology program, he received his bachelor's degree from the University of Applied Science Bingen, Germany with a major in biotechnology. He received additional training in a Molecular Biology master program at the Goethe University Frankfurt, Germany before pursuing his education in physiology at MCW. His research interests are whole organ physiology with a focus on cardiovascular pathology in response to clinical used anti-cancer therapy. Lukas aims to utilize rodent models to investigate physiological and molecular changes that lead to cardiovascular disease.
Cristhian Gutierrez Huerta
Research Assistant
cgutierrez@mcw.edu
Cristhian Gutierrez Huerta is a graduate MSTP student in the Beyer/Gutterman Lab. He graduated with a BS in Applied Mathematics and Biological Sciences from the University of California, Merced in 2018. He then completed a 2-yr post-baccalaureate research fellowship at the National Heart, Lung, and Blood Institute. In the Beyer/Gutterman group, he will begin work on identifying the role of mitochondrial fission/fusion on microvascular endothelial function and its relationship to coronary artery disease progression.
Karen Clark, PhD
Postdoctoral Fellow
kaclark@mcw.edu
Karen Clark is a postdoctoral fellow working with Drs Beyer and Kriegel to investigate biological factors that lead to disparate chemotherapy treatment outcomes in breast cancer patients of color compared to Caucasian women. She is also studying the role of mitofusin 1 in the vascular endothelium and whether overexpression is a protective factor against certain stressors. Prior to joining the team, she earned her PhD in Genetics at the University of Iowa, investigating the genetic basis of susceptibility to complex diseases in a rat model of Metabolic Syndrome. Her research interests include Precision Medicine, cancer biology, and metabolism.
Alumni/Former Trainees
- Karima Ait-Aissa
- Daniela Didier
- Johnathan Ebben
- Alena Hanson
- Joe Hockenberry
- Andrew D. Kadlec, PhD
- Minhi Kang
- Todd Le
- Jasmine Linn
- Micaela Young
Recent Publications
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Nedd4-2 upregulation is associated with ACE2 ubiquitination in hypertension.
(Mohammed M, Ogunlade B, Elgazzaz M, Berdasco C, Lakkappa N, Ghita I, Guidry JJ, Sriramula S, Xu J, Restivo L, Mendiola Plá MA, Bowles DE, Beyer AM, Yue X, Lazartigues E, Filipeanu CM.) Cardiovasc Res. 2023 May 10 PMID: 37161607 05/10/2023
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Differential impacts of COVID-19 variants on human microvascular function.
(Nishijima Y, Hader SN, Beyer AM.) Cardiovasc Res. 2023 Mar 17;119(1):e115-e117 PMID: 36708228 SCOPUS ID: 2-s2.0-85150665595 01/29/2023
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(Chabowski DS, Hughes WE, Hockenberry JC, LoGiudice J, Beyer AM, Gutterman DD.) J Physiol. 2023 Feb;601(3):469-481 PMID: 36575638 SCOPUS ID: 2-s2.0-85145823691 12/29/2022
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New developments in translational microcirculatory research.
(SenthilKumar G, Gutierrez-Huerta CA, Freed JK, Beyer AM, Fancher IS, LeBlanc AJ.) Am J Physiol Heart Circ Physiol. 2022 Dec 01;323(6):H1167-H1175 PMID: 36306213 PMCID: PMC9678417 SCOPUS ID: 2-s2.0-85142403599 10/29/2022
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(Tracy EP, Nair R, Rowe G, Beare JE, Beyer A, LeBlanc AJ.) Am J Physiol Heart Circ Physiol. 2022 Oct 01;323(4):H749-H762 PMID: 36018760 PMCID: PMC9529257 SCOPUS ID: 2-s2.0-85139376250 08/27/2022
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Emerging mitochondrial signaling mechanisms in cardio-oncology: beyond oxidative stress.
(Bikomeye JC, Terwoord JD, Santos JH, Beyer AM.) Am J Physiol Heart Circ Physiol. 2022 Oct 01;323(4):H702-H720 PMID: 35930448 PMCID: PMC9529263 SCOPUS ID: 2-s2.0-85139374997 08/06/2022
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Endothelial dysfunction as a complication of anti-cancer therapy.
(Terwoord JD, Beyer AM, Gutterman DD.) Pharmacol Ther. 2022 Sep;237:108116 PMID: 35063569 PMCID: PMC9294076 SCOPUS ID: 2-s2.0-85123611979 01/23/2022
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(Bikomeye JC, Beyer AM, Kwarteng JL, Beyer KMM.) Int J Environ Res Public Health. 2022 Feb 19;19(4) PMID: 35206610 PMCID: PMC8872601 SCOPUS ID: 2-s2.0-85124908145 02/26/2022
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(Bikomeye JC, Balza JS, Kwarteng JL, Beyer AM, Beyer KMM.) PLoS One. 2022;17(11):e0276517 PMID: 36417344 PMCID: PMC9683573 SCOPUS ID: 2-s2.0-85142876878 11/24/2022
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(Ait-Aissa K, Norwood-Toro LE, Terwoord J, Young M, Paniagua LA, Hader SN, Hughes WE, Hockenberry JC, Beare JE, Linn J, Kohmoto T, Kim J, Betts DH, LeBlanc AJ, Gutterman DD, Beyer AM.) Function (Oxf). 2022;3(5):zqac043 PMID: 36168588 PMCID: PMC9508843 09/29/2022
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Lisinopril Mitigates Radiation-Induced Mitochondrial Defects in Rat Heart and Blood Cells.
(Ortiz de Choudens S, Sparapani R, Narayanan J, Lohr N, Gao F, Fish BL, Zielonka M, Gasperetti T, Veley D, Beyer A, Olson J, Jacobs ER, Medhora M.) Front Oncol. 2022;12:828177 PMID: 35311118 PMCID: PMC8924663 SCOPUS ID: 2-s2.0-85126780777 03/22/2022
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(Bikomeye JC, Beyer AM, Kwarteng JL, Beyer KMM.) International Journal of Environmental Research and Public Health. February-2 2022;19(4) SCOPUS ID: 2-s2.0-85124908145 02/01/2022