Aron Geurts Lab | Cardiovascular Center | Medical College of Wisconsin

Geurts Lab

AronGeurts

Aron Geurts, PhD
Principal Investigator
Associate Professor, Department of Physiology
ageurts@mcw.edu

Dr. Geurts is an Associate Professor in the Department of Physiology, Cardiovascular Research Center and Genomic Sciences and Precision Medicine Center. He leads an NIH-funded research team focused on innovating novel approaches to genetic engineering and creating animal and cell models of complex genetic human diseases. He is a recipient of a prestigious New Innovator award from the Office of the Director of the NIH.

Michael Grzybowski

Michael Grzybowski
Laboratory Supervisor
mgrzybowski@mcw.edu

My role in Dr. Aron Geurts' lab is to help facilitate the creation of genetically modified models. I design nuclease reagents that are then created and validated in the Geurts lab that will be used to create these modifications. I am also responsible for the day to day operations in the lab. My research interests are mainly molecular biology and technology and how to create and develop animal models.

Akiko Takizawa

Akiko Takizawa
Research Scientist II
atakizawa@mcw.edu

My research interests are related to reproductive biology in rats. I am especially interested in assisted reproductive technology such as cryopreservation of gametes and zygotes, re-derivation and embryo manipulation. These technologies are reliable methods to preserve strains which were generated using new gene modification technologies such as Zinc Finger Nucleases (ZFNs) and TAL Effector Nucleases (TALENs), to avoid breeding problems. I am also interested in the development of more effective sperm cryopreservation and nuclear transfer technology.

Jason Klotz

Jason Klotz
Research Technologist III
jklotz@mcw.edu

Under Dr. Geurts I help coordinate the business conducted in the Rat Transgenic Service Center. I also perform micro-injections and sperm cryopreservation for the Service Center.

Mutation of RORγT reveals a role for Th17 cells in both injury and recovery from renal ischemia reperfusion injury.

(Mehrotra P, Ullah MM, Collett JA, Myers SL, Dwinell MR, Geurts AM, Basile DP.) Am J Physiol Renal Physiol. 2020 Sep 14 PMID: 32924545 09/15/2020
Development of an endothelial cell-restricted transgenic reporter rat: a resource for physiological studies of vascular biology.

(Alexeyev M, Geurts AM, Annamdevula NS, Francis CM, Leavesley SJ, Rich TC, Taylor MS, Lin MT, Balczon R, Knighten JM, Alvarez DF, Stevens T.) Am J Physiol Heart Circ Physiol. 2020 08 01;319(2):H349-H358 PMID: 32589443 PMCID: PMC7473926 SCOPUS ID: 2-s2.0-85088491118 06/27/2020
CRISPR-Mediated Single Nucleotide Polymorphism Modeling in Rats Reveals Insight Into Reduced Cardiovascular Risk Associated With Mediterranean G6PD Variant.

(Kitagawa A, Kizub I, Jacob C, Michael K, D'Alessandro A, Reisz JA, Grzybowski M, Geurts AM, Rocic P, Gupte R, Miano JM, Gupte SA.) Hypertension. 2020 Aug;76(2):523-532 PMID: 32507041 SCOPUS ID: 2-s2.0-85088206977 06/09/2020
UBASH3A deficiency accelerates type 1 diabetes development and enhances salivary gland inflammation in NOD mice.

(Chen YG, Ciecko AE, Khaja S, Grzybowski M, Geurts AM, Lieberman SM.) Sci Rep. 2020 07 21;10(1):12019 PMID: 32694640 PMCID: PMC7374577 SCOPUS ID: 2-s2.0-85088288172 07/23/2020
Endogenous miR-204 Protects the Kidney against Chronic Injury in Hypertension and Diabetes.

(Cheng Y, Wang D, Wang F, Liu J, Huang B, Baker MA, Yin J, Wu R, Liu X, Regner KR, Usa K, Liu Y, Zhang C, Dong L, Geurts AM, Wang N, Miller SS, He Y, Liang M.) J Am Soc Nephrol. 2020 Jul;31(7):1539-1554 PMID: 32487559 PMCID: PMC7350998 SCOPUS ID: 2-s2.0-85087468924 06/04/2020
Diurnal Control of Blood Pressure Is Uncoupled From Sodium Excretion.

(Johnston JG, Speed JS, Becker BK, Kasztan M, Soliman RH, Rhoads MK, Tao B, Jin C, Geurts AM, Hyndman KA, Pollock JS, Pollock DM.) Hypertension. 2020 Jun;75(6):1624-1634 PMID: 32306766 PMCID: PMC7228023 SCOPUS ID: 2-s2.0-85084695306 04/21/2020
The CD137 Ligand Is Important for Type 1 Diabetes Development but Dispensable for the Homeostasis of Disease-Suppressive CD137+ FOXP3+ Regulatory CD4 T Cells.

(Foda BM, Ciecko AE, Serreze DV, Ridgway WM, Geurts AM, Chen YG.) J Immunol. 2020 Jun 01;204(11):2887-2899 PMID: 32295876 PMCID: PMC7296588 SCOPUS ID: 2-s2.0-85084888777 04/17/2020
Transcriptional analysis of the multiple Sry genes and developmental program at the onset of testis differentiation in the rat.

(Prokop JW, Chhetri SB, van Veen JE, Chen X, Underwood AC, Uhl K, Dwinell MR, Geurts AM, Correa SM, Arnold AP.) Biol Sex Differ. 2020 05 12;11(1):28 PMID: 32398044 PMCID: PMC7216353 SCOPUS ID: 2-s2.0-85084627810 05/14/2020
CD226 Deletion Reduces Type 1 Diabetes in the NOD Mouse by Impairing Thymocyte Development and Peripheral T Cell Activation

(Shapiro MR, Yeh WI, Longfield JR, Gallagher J, Infante CM, Wellford S, Posgai AL, Atkinson MA, Campbell-Thompson M, Lieberman SM, Serreze DV, Geurts AM, Chen YG, Brusko TM.) Frontiers in Immunology. 4 September 2020;11 SCOPUS ID: 2-s2.0-85091212749 09/04/2020
Contractility of Induced Pluripotent Stem Cell-Cardiomyocytes With an MYH6 Head Domain Variant Associated With Hypoplastic Left Heart Syndrome.

(Kim MS, Fleres B, Lovett J, Anfinson M, Samudrala SSK, Kelly LJ, Teigen LE, Cavanaugh M, Marquez M, Geurts AM, Lough JW, Mitchell ME, Fitts RH, Tomita-Mitchell A.) Front Cell Dev Biol. 2020;8:440 PMID: 32656206 PMCID: PMC7324479 07/14/2020
Contractility of Induced Pluripotent Stem Cell-Cardiomyocytes With an MYH6 Head Domain Variant Associated With Hypoplastic Left Heart Syndrome

(Kim MS, Fleres B, Lovett J, Anfinson M, Samudrala SSK, Kelly LJ, Teigen LE, Cavanaugh M, Marquez M, Geurts AM, Lough JW, Mitchell ME, Fitts RH, Tomita-Mitchell A.) Frontiers in Cell and Developmental Biology. 23 June 2020;8 SCOPUS ID: 2-s2.0-85087475806 06/23/2020
Interaction between Mas1 and AT1RA contributes to enhancement of skeletal muscle angiogenesis by angiotensin-(1-7) in Dahl salt-sensitive rats.

(Exner EC, Geurts AM, Hoffmann BR, Casati M, Stodola T, Dsouza NR, Zimmermann M, Lombard JH, Greene AS.) PLoS One. 2020;15(4):e0232067 PMID: 32324784 PMCID: PMC7179868 SCOPUS ID: 2-s2.0-85083695035 04/24/2020

Cardiovascular Center

Geurts Lab

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