Geurts Lab
Aron Geurts, PhD
Principal Investigator
Associate Professor, Department of Physiology
ageurts@mcw.edu
Dr. Geurts is an Associate Professor in the Department of Physiology, Cardiovascular Research Center and Genomic Sciences and Precision Medicine Center. He leads an NIH-funded research team focused on innovating novel approaches to genetic engineering and creating animal and cell models of complex genetic human diseases. He is a recipient of a prestigious New Innovator award from the Office of the Director of the NIH.
Michael Grzybowski
Laboratory Supervisor
mgrzybowski@mcw.edu
My role in Dr. Aron Geurts' lab is to help facilitate the creation of genetically modified models. I design nuclease reagents that are then created and validated in the Geurts lab that will be used to create these modifications. I am also responsible for the day to day operations in the lab. My research interests are mainly molecular biology and technology and how to create and develop animal models.
Akiko Takizawa
Research Scientist II
atakizawa@mcw.edu
My research interests are related to reproductive biology in rats. I am especially interested in assisted reproductive technology such as cryopreservation of gametes and zygotes, re-derivation and embryo manipulation. These technologies are reliable methods to preserve strains which were generated using new gene modification technologies such as Zinc Finger Nucleases (ZFNs) and TAL Effector Nucleases (TALENs), to avoid breeding problems. I am also interested in the development of more effective sperm cryopreservation and nuclear transfer technology.
Jason Klotz
Research Technologist III
jklotz@mcw.edu
Under Dr. Geurts I help coordinate the business conducted in the Rat Transgenic Service Center. I also perform micro-injections and sperm cryopreservation for the Service Center.
Recent Publications
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Hepatic pathology and altered gene transcription in a murine model of acid ceramidase deficiency.
(Yu FPS, Molino S, Sikora J, Rasmussen S, Rybova J, Tate E, Geurts AM, Turner PV, Mckillop WM, Medin JA.) Lab Invest. 2019 Oct;99(10):1572-1592.
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(Xue H, Geurts AM, Usa K, Wang F, Lin Y, Phillips J, Henderson L, Baker MA, Tian Z, Liang M.) Hypertension. 2019 Aug;74(2):313-322.
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(Zhang C, He X, Murphy SR, Zhang H, Wang S, Ge Y, Gao W, Williams JM, Geurts AM, Roman RJ, Fan F.) J Pharmacol Exp Ther. 2019 Aug;370(2):206-217.
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The p52 isoform of SHC1 is a key driver of breast cancer initiation.
(Wright KD, Miller BS, El-Meanawy S, Tsaih SW, Banerjee A, Geurts AM, Sheinin Y, Sun Y, Kalyanaraman B, Rui H, Flister MJ, Sorokin A.) Breast Cancer Res. 2019 06 15;21(1):74.
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(Kim J, Martin A, Yee J, Fojut L, Geurts AM, Oshima K, Zimmerman MA, Hong JC.) J Surg Res. 2019 Mar;235:73-82.
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MiR-192-5p in the Kidney Protects Against the Development of Hypertension.
(Baker MA, Wang F, Liu Y, Kriegel AJ, Geurts AM, Usa K, Xue H, Wang D, Kong Y, Liang M.) Hypertension. 2019 Feb;73(2):399-406.
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Telomerase Deficiency Predisposes to Heart Failure and Ischemia-Reperfusion Injury.
(Ait-Aissa K, Heisner JS, Norwood Toro LE, Bruemmer D, Doyon G, Harmann L, Geurts A, Camara AKS, Beyer AM.) Front Cardiovasc Med. 2019;6:31.
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CD11c Cells Are Gatekeepers for Lymphocyte Trafficking to Infiltrated Islets During Type 1 Diabetes.
(Sandor AM, Lindsay RS, Dyjack N, Whitesell JC, Rios C, Bradley BJ, Haskins K, Serreze DV, Geurts AM, Chen YG, Seibold MA, Jacobelli J, Friedman RS.) Front Immunol. 2019;10:99.
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(Jing R, Corbett JL, Cai J, Beeson GC, Beeson CC, Chan SS, Dimmock DP, Lazcares L, Geurts AM, Lemasters JJ, Duncan SA.) Cell Rep. 2018 11 06;25(6):1469-1484.e5.
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(Presa M, Racine JJ, Dwyer JR, Lamont DJ, Ratiu JJ, Sarsani VK, Chen YG, Geurts A, Schmitz I, Stearns T, Allocco J, Chapman HD, Serreze DV.) J Immunol. 2018 10 01;201(7):1907-1917.
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MicroRNA-214-3p in the Kidney Contributes to the Development of Hypertension.
(Liu Y, Usa K, Wang F, Liu P, Geurts AM, Li J, Williams AM, Regner KR, Kong Y, Liu H, Nie J, Liang M.) J Am Soc Nephrol. 2018 10;29(10):2518-2528.
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Tissue-specific effects of targeted mutation of Mir29b1 in rats.
(Xue H, Zhang G, Geurts AM, Usa K, Jensen DM, Liu Y, Widlansky ME, Liang M.) EBioMedicine. 2018 Sep;35:260-269.