Geurts Lab

AronGeurts

Aron Geurts, PhD
Principal Investigator
Professor, Department of Physiology
ageurts@mcw.edu

Dr. Geurts is a professor in the department of physiology, Cardiovascular Research Center and Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Medicine. He leads an NIH-funded research team focused on innovating novel approaches to genetic engineering and creating animal and cell models of complex genetic human diseases. He is a recipient of a prestigious New Innovator award from the Office of the Director of the NIH.

Michael Grzybowski

Michael Grzybowski
Laboratory Supervisor
mgrzybowski@mcw.edu

My role in Dr. Aron Geurts' lab is to help facilitate the creation of genetically modified models. I design nuclease reagents that are then created and validated in the Geurts lab that will be used to create these modifications. I am also responsible for the day to day operations in the lab. My research interests are mainly molecular biology and technology and how to create and develop animal models.

Akiko Takizawa

Akiko Takizawa
Research Scientist II
atakizawa@mcw.edu

My research interests are related to reproductive biology in rats. I am especially interested in assisted reproductive technology such as cryopreservation of gametes and zygotes, re-derivation and embryo manipulation. These technologies are reliable methods to preserve strains which were generated using new gene modification technologies such as Zinc Finger Nucleases (ZFNs) and TAL Effector Nucleases (TALENs), to avoid breeding problems. I am also interested in the development of more effective sperm cryopreservation and nuclear transfer technology.

Jason Klotz

Jason Klotz
Research Technologist III
jklotz@mcw.edu

Under Dr. Geurts I help coordinate the business conducted in the Rat Transgenic Service Center. I also perform micro-injections and sperm cryopreservation for the Service Center.

SIGIRR Mutation in Human Necrotizing Enterocolitis (NEC) Disrupts STAT3-Dependent microRNA Expression in Neonatal Gut.

(Yu W, Haque I, Venkatraman A, Menden HL, Mabry SM, Roy BC, Xia S, Prokop JW, Umar S, Geurts AM, Sampath V.) Cell Mol Gastroenterol Hepatol. 2022;13(2):425-440 PMID: 34563711 PMCID: PMC8688179 SCOPUS ID: 2-s2.0-85121348500 09/27/2021
p66Shc-mediated hydrogen peroxide production impairs nephrogenesis causing reduction of number of glomeruli.

(Miller B, Palygin O, El-Meanawy A, Mattson DL, Geurts AM, Staruschenko A, Sorokin A.) Life Sci. 2021 Aug 15;279:119661 PMID: 34087282 PMCID: PMC8265215 SCOPUS ID: 2-s2.0-85107260373 06/05/2021
Double p52Shc/p46Shc Rat Knockout Demonstrates Severe Gait Abnormalities Accompanied by Dilated Cardiomyopathy.

(Miller B, Kostrominova TY, Geurts AM, Sorokin A.) Int J Mol Sci. 2021 May 15;22(10) PMID: 34063460 PMCID: PMC8155973 SCOPUS ID: 2-s2.0-85105734035 06/03/2021
Double p52shc/p46shc rat knockout demonstrates severe gait abnormalities accompanied by dilated cardiomyopathy

(Miller B, Kostrominova TY, Geurts AM, Sorokin A.) International Journal of Molecular Sciences. 2 May 2021;22(10) SCOPUS ID: 2-s2.0-85105734035 05/02/2021
Interleukin-27 is essential for type 1 diabetes development and Sjögren syndrome-like inflammation.

(Ciecko AE, Foda B, Barr JY, Ramanathan S, Atkinson MA, Serreze DV, Geurts AM, Lieberman SM, Chen YG.) Cell Rep. 2021 Feb 02;34(5):108725 PMID: 33535031 PMCID: PMC7923249 SCOPUS ID: 2-s2.0-85100240717 02/04/2021
Generation of a novel decay accelerating factor (DAF) knock-out rat model using clustered regularly-interspaced short palindromic repeats, (CRISPR)/associated protein 9 (Cas9), genome editing.

(Detsika MG, Goudevenou K, Geurts AM, Gakiopoulou H, Grapsa E, Lianos EA.) Transgenic Res. 2021 02;30(1):11-21 PMID: 33387103 SCOPUS ID: 2-s2.0-85098488124 01/03/2021
Erratum: Interleukin-27 is essential for type 1 diabetes development and Sjögren syndrome-like inflammation (Cell Reports (2019) 29(10) (3073–3086.e5), (S2211124719314810), (10.1016/j.celrep.2019.11.010))

(Ciecko AE, Foda B, Barr JY, Ramanathan S, Atkinson MA, Serreze DV, Geurts AM, Lieberman SM, Chen YG.) Cell Reports. 2 February 2021;34(5) SCOPUS ID: 2-s2.0-85100240717 02/02/2021
Generation of a novel decay accelerating factor (DAF) knock-out rat model using clustered regularly-interspaced short palindromic repeats, (CRISPR)/associated protein 9 (Cas9), genome editing

(Detsika MG, Goudevenou K, Geurts AM, Gakiopoulou H, Grapsa E, Lianos EA.) Transgenic Research. February 2021;30(1):11-21 SCOPUS ID: 2-s2.0-85098488124 02/01/2021
Hyperspectral imaging approaches to characterize the distribution and expression of FRET in tissues isolated from a novel transgenic rat expressing a FRET-based probe

(Annamdevula N, Geurts A, Leavesley SJ, Rich TC.) Progress in Biomedical Optics and Imaging - Proceedings of SPIE. 2021;11649 SCOPUS ID: 2-s2.0-85107765344 01/01/2021
Assessing drug-cell and drug-tissue interactions through spectral FRET imaging

(Leavesley SJ, Annamdevula N, Geurts A, Pleshinger DJ, Rich TC.) Progress in Biomedical Optics and Imaging - Proceedings of SPIE. 2021;11624 SCOPUS ID: 2-s2.0-85108869819 01/01/2021
Sexual Dimorphic Role of CD14 (Cluster of Differentiation 14) in Salt-Sensitive Hypertension and Renal Injury.

(Fehrenbach DJ, Abais-Battad JM, Dasinger JH, Lund H, Keppel T, Zemaj J, Cherian-Shaw M, Gundry RL, Geurts AM, Dwinell MR, Mattson DL.) Hypertension. 2021 01;77(1):228-240 PMID: 33249861 SCOPUS ID: 2-s2.0-85097815793 12/01/2020
Toll-Like Receptor 7 Is Required for Lacrimal Gland Autoimmunity and Type 1 Diabetes Development in Male Nonobese Diabetic Mice.

(Debreceni IL, Chimenti MS, Serreze DV, Geurts AM, Chen YG, Lieberman SM.) Int J Mol Sci. 2020 Dec 13;21(24) PMID: 33322152 PMCID: PMC7764018 SCOPUS ID: 2-s2.0-85097667415 12/17/2020

Cardiovascular Center

Geurts Lab

Recent Publications