Aron Geurts Lab | Cardiovascular Center | Medical College of Wisconsin

Geurts Lab

AronGeurts

Aron Geurts, PhD
Principal Investigator
Associate Professor, Department of Physiology
ageurts@mcw.edu

Dr. Geurts is an Associate Professor in the Department of Physiology, Cardiovascular Research Center and Genomic Sciences and Precision Medicine Center. He leads an NIH-funded research team focused on innovating novel approaches to genetic engineering and creating animal and cell models of complex genetic human diseases. He is a recipient of a prestigious New Innovator award from the Office of the Director of the NIH.

Michael Grzybowski

Michael Grzybowski
Laboratory Supervisor
mgrzybowski@mcw.edu

My role in Dr. Aron Geurts' lab is to help facilitate the creation of genetically modified models. I design nuclease reagents that are then created and validated in the Geurts lab that will be used to create these modifications. I am also responsible for the day to day operations in the lab. My research interests are mainly molecular biology and technology and how to create and develop animal models.

Akiko Takizawa

Akiko Takizawa
Research Scientist II
atakizawa@mcw.edu

My research interests are related to reproductive biology in rats. I am especially interested in assisted reproductive technology such as cryopreservation of gametes and zygotes, re-derivation and embryo manipulation. These technologies are reliable methods to preserve strains which were generated using new gene modification technologies such as Zinc Finger Nucleases (ZFNs) and TAL Effector Nucleases (TALENs), to avoid breeding problems. I am also interested in the development of more effective sperm cryopreservation and nuclear transfer technology.

Jason Klotz

Jason Klotz
Research Technologist III
jklotz@mcw.edu

Under Dr. Geurts I help coordinate the business conducted in the Rat Transgenic Service Center. I also perform micro-injections and sperm cryopreservation for the Service Center.

Kidney failure, arterial hypertension and left ventricular hypertrophy in rats with loss of function mutation of SOD3.

(Guo H, Xu D, Kuroki M, Lu Z, Xu X, Geurts A, Osborn JW, Chen Y.) Free Radic Biol Med. 2020 May 20;152:787-796 PMID: 31972339 SCOPUS ID: 2-s2.0-85078520570 01/24/2020
A galactose-1-phosphate uridylyltransferase-null rat model of classic galactosemia mimics relevant patient outcomes and reveals tissue-specific and longitudinal differences in galactose metabolism.

(Rasmussen SA, Daenzer JMI, MacWilliams JA, Head ST, Williams MB, Geurts AM, Schroeder JP, Weinshenker D, Fridovich-Keil JL.) J Inherit Metab Dis. 2020 May;43(3):518-528 PMID: 31845342 PMCID: PMC7318568 SCOPUS ID: 2-s2.0-85077897416 12/18/2019
A Mutation in γ-Adducin Impairs Autoregulation of Renal Blood Flow and Promotes the Development of Kidney Disease.

(Fan F, Geurts AM, Pabbidi MR, Ge Y, Zhang C, Wang S, Liu Y, Gao W, Guo Y, Li L, He X, Lv W, Muroya Y, Hirata T, Prokop J, Booz GW, Jacob HJ, Roman RJ.) J Am Soc Nephrol. 2020 Apr;31(4):687-700 PMID: 32029431 PMCID: PMC7191921 SCOPUS ID: 2-s2.0-85082881644 02/08/2020
Robust and replicable measurement for prepulse inhibition of the acoustic startle response.

(Miller EA, Kastner DB, Grzybowski MN, Dwinell MR, Geurts AM, Frank LM.) Mol Psychiatry. 2020 Mar 06 PMID: 32144356 SCOPUS ID: 2-s2.0-85081733376 03/08/2020
Comparative and Functional Genomic Resource for Mechanistic Studies of Human Blood Pressure-Associated Single Nucleotide Polymorphisms.

(Mishra MK, Liang EY, Geurts AM, Auer PWL, Liu P, Rao S, Greene AS, Liang M, Liu Y.) Hypertension. 2020 Mar;75(3):859-868 PMID: 31902252 PMCID: PMC7035167 SCOPUS ID: 2-s2.0-85081142576 01/07/2020
The severe spontaneous bleeding phenotype in a novel hemophilia A rat model is rescued by platelet FVIII expression.

(Shi Q, Mattson JG, Fahs SA, Geurts AM, Weiler H, Montgomery RR.) Blood Adv. 2020 Jan 14;4(1):55-65 PMID: 31899798 PMCID: PMC6960468 SCOPUS ID: 2-s2.0-85078174834 01/04/2020
A rat model of severe VWD by elimination of the VWF gene using CRISPR/Cas9.

(Garcia J, Flood VH, Haberichter SL, Fahs SA, Mattson JG, Geurts AM, Zogg M, Weiler H, Shi Q, Montgomery RR.) Res Pract Thromb Haemost. 2020 Jan;4(1):64-71 PMID: 31989086 PMCID: PMC6971331 01/29/2020
Interleukin-27 Is Essential for Type 1 Diabetes Development and Sjögren Syndrome-like Inflammation.

(Ciecko AE, Foda B, Barr JY, Ramanathan S, Atkinson MA, Serreze DV, Geurts AM, Lieberman SM, Chen YG.) Cell Rep. 2019 12 03;29(10):3073-3086.e5 PMID: 31801074 PMCID: PMC6914223 SCOPUS ID: 2-s2.0-85075892781 12/05/2019
miR-146b-5p has a sex-specific role in renal and cardiac pathology in a rat model of chronic kidney disease.

(Paterson MR, Geurts AM, Kriegel AJ.) Kidney Int. 2019 12;96(6):1332-1345 PMID: 31668631 PMCID: PMC6941490 SCOPUS ID: 2-s2.0-85074541202 11/02/2019
Knockout of P2rx7 purinergic receptor attenuates cyst growth in a rat model of ARPKD.

(Arkhipov SN, Potter DL, Geurts AM, Pavlov TS.) Am J Physiol Renal Physiol. 2019 12 01;317(6):F1649-F1655 PMID: 31630543 PMCID: PMC6960783 SCOPUS ID: 2-s2.0-85075959618 10/22/2019
Investigation of a dilated cardiomyopathy-associated variant in BAG3 using genome-edited iPSC-derived cardiomyocytes.

(McDermott-Roe C, Lv W, Maximova T, Wada S, Bukowy J, Marquez M, Lai S, Shehu A, Benjamin I, Geurts A, Musunuru K.) JCI Insight. 2019 11 14;4(22) PMID: 31723063 PMCID: PMC6948852 SCOPUS ID: 2-s2.0-85077370393 11/15/2019
Habenular TCF7L2 links nicotine addiction to diabetes.

(Duncan A, Heyer MP, Ishikawa M, Caligiuri SPB, Liu XA, Chen Z, Micioni Di Bonaventura MV, Elayouby KS, Ables JL, Howe WM, Bali P, Fillinger C, Williams M, O'Connor RM, Wang Z, Lu Q, Kamenecka TM, Ma'ayan A, O'Neill HC, Ibanez-Tallon I, Geurts AM, Kenny PJ.) Nature. 2019 10;574(7778):372-377 PMID: 31619789 SCOPUS ID: 2-s2.0-85073431118 10/18/2019

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Geurts Lab

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