Aron Geurts Lab | Cardiovascular Center | Medical College of Wisconsin

Geurts Lab

AronGeurts

Aron Geurts, PhD
Principal Investigator
Associate Professor, Department of Physiology
ageurts@mcw.edu

Dr. Geurts is an Associate Professor in the Department of Physiology, Cardiovascular Research Center and Genomic Sciences and Precision Medicine Center. He leads an NIH-funded research team focused on innovating novel approaches to genetic engineering and creating animal and cell models of complex genetic human diseases. He is a recipient of a prestigious New Innovator award from the Office of the Director of the NIH.

Michael Grzybowski

Michael Grzybowski
Laboratory Supervisor
mgrzybowski@mcw.edu

My role in Dr. Aron Geurts' lab is to help facilitate the creation of genetically modified models. I design nuclease reagents that are then created and validated in the Geurts lab that will be used to create these modifications. I am also responsible for the day to day operations in the lab. My research interests are mainly molecular biology and technology and how to create and develop animal models.

Akiko Takizawa

Akiko Takizawa
Research Scientist II
atakizawa@mcw.edu

My research interests are related to reproductive biology in rats. I am especially interested in assisted reproductive technology such as cryopreservation of gametes and zygotes, re-derivation and embryo manipulation. These technologies are reliable methods to preserve strains which were generated using new gene modification technologies such as Zinc Finger Nucleases (ZFNs) and TAL Effector Nucleases (TALENs), to avoid breeding problems. I am also interested in the development of more effective sperm cryopreservation and nuclear transfer technology.

Jason Klotz

Jason Klotz
Research Technologist III
jklotz@mcw.edu

Under Dr. Geurts I help coordinate the business conducted in the Rat Transgenic Service Center. I also perform micro-injections and sperm cryopreservation for the Service Center.

Generation of a novel decay accelerating factor (DAF) knock-out rat model using clustered regularly-interspaced short palindromic repeats, (CRISPR)/associated protein 9 (Cas9), genome editing

(Detsika MG, Goudevenou K, Geurts AM, Gakiopoulou H, Grapsa E, Lianos EA.) Transgenic Research. 2021 SCOPUS ID: 2-s2.0-85098488124 01/01/2021
Sexual Dimorphic Role of CD14 (Cluster of Differentiation 14) in Salt-Sensitive Hypertension and Renal Injury.

(Fehrenbach DJ, Abais-Battad JM, Dasinger JH, Lund H, Keppel T, Zemaj J, Cherian-Shaw M, Gundry RL, Geurts AM, Dwinell MR, Mattson DL.) Hypertension. 2021 Jan;77(1):228-240 PMID: 33249861 SCOPUS ID: 2-s2.0-85097815793 12/01/2020
Toll-Like Receptor 7 Is Required for Lacrimal Gland Autoimmunity and Type 1 Diabetes Development in Male Nonobese Diabetic Mice.

(Debreceni IL, Chimenti MS, Serreze DV, Geurts AM, Chen YG, Lieberman SM.) Int J Mol Sci. 2020 Dec 13;21(24) PMID: 33322152 PMCID: PMC7764018 SCOPUS ID: 2-s2.0-85097667415 12/17/2020
Mutation of RORγT reveals a role for Th17 cells in both injury and recovery from renal ischemia-reperfusion injury.

(Mehrotra P, Ullah MM, Collett JA, Myers SL, Dwinell MR, Geurts AM, Basile DP.) Am J Physiol Renal Physiol. 2020 11 01;319(5):F796-F808 PMID: 32924545 SCOPUS ID: 2-s2.0-85094221372 09/15/2020
Development of an endothelial cell-restricted transgenic reporter rat: a resource for physiological studies of vascular biology.

(Alexeyev M, Geurts AM, Annamdevula NS, Francis CM, Leavesley SJ, Rich TC, Taylor MS, Lin MT, Balczon R, Knighten JM, Alvarez DF, Stevens T.) Am J Physiol Heart Circ Physiol. 2020 08 01;319(2):H349-H358 PMID: 32589443 PMCID: PMC7473926 SCOPUS ID: 2-s2.0-85088491118 06/27/2020
CRISPR-Mediated Single Nucleotide Polymorphism Modeling in Rats Reveals Insight Into Reduced Cardiovascular Risk Associated With Mediterranean G6PD Variant.

(Kitagawa A, Kizub I, Jacob C, Michael K, D'Alessandro A, Reisz JA, Grzybowski M, Geurts AM, Rocic P, Gupte R, Miano JM, Gupte SA.) Hypertension. 2020 Aug;76(2):523-532 PMID: 32507041 PMCID: PMC7726709 SCOPUS ID: 2-s2.0-85088206977 06/09/2020
UBASH3A deficiency accelerates type 1 diabetes development and enhances salivary gland inflammation in NOD mice.

(Chen YG, Ciecko AE, Khaja S, Grzybowski M, Geurts AM, Lieberman SM.) Sci Rep. 2020 07 21;10(1):12019 PMID: 32694640 PMCID: PMC7374577 SCOPUS ID: 2-s2.0-85088288172 07/23/2020
Endogenous miR-204 Protects the Kidney against Chronic Injury in Hypertension and Diabetes.

(Cheng Y, Wang D, Wang F, Liu J, Huang B, Baker MA, Yin J, Wu R, Liu X, Regner KR, Usa K, Liu Y, Zhang C, Dong L, Geurts AM, Wang N, Miller SS, He Y, Liang M.) J Am Soc Nephrol. 2020 Jul;31(7):1539-1554 PMID: 32487559 PMCID: PMC7350998 SCOPUS ID: 2-s2.0-85087468924 06/04/2020
CD226 Deletion Reduces Type 1 Diabetes in the NOD Mouse by Impairing Thymocyte Development and Peripheral T Cell Activation.

(Shapiro MR, Yeh WI, Longfield JR, Gallagher J, Infante CM, Wellford S, Posgai AL, Atkinson MA, Campbell-Thompson M, Lieberman SM, Serreze DV, Geurts AM, Chen YG, Brusko TM.) Front Immunol. 2020;11:2180 PMID: 33013915 PMCID: PMC7500101 SCOPUS ID: 2-s2.0-85091212749 10/06/2020
CD226 Deletion Reduces Type 1 Diabetes in the NOD Mouse by Impairing Thymocyte Development and Peripheral T Cell Activation

(Shapiro MR, Yeh WI, Longfield JR, Gallagher J, Infante CM, Wellford S, Posgai AL, Atkinson MA, Campbell-Thompson M, Lieberman SM, Serreze DV, Geurts AM, Chen YG, Brusko TM.) Frontiers in Immunology. 4 September 2020;11 SCOPUS ID: 2-s2.0-85091212749 09/04/2020
Contractility of Induced Pluripotent Stem Cell-Cardiomyocytes With an MYH6 Head Domain Variant Associated With Hypoplastic Left Heart Syndrome.

(Kim MS, Fleres B, Lovett J, Anfinson M, Samudrala SSK, Kelly LJ, Teigen LE, Cavanaugh M, Marquez M, Geurts AM, Lough JW, Mitchell ME, Fitts RH, Tomita-Mitchell A.) Front Cell Dev Biol. 2020;8:440 PMID: 32656206 PMCID: PMC7324479 07/14/2020
Contractility of Induced Pluripotent Stem Cell-Cardiomyocytes With an MYH6 Head Domain Variant Associated With Hypoplastic Left Heart Syndrome

(Kim MS, Fleres B, Lovett J, Anfinson M, Samudrala SSK, Kelly LJ, Teigen LE, Cavanaugh M, Marquez M, Geurts AM, Lough JW, Mitchell ME, Fitts RH, Tomita-Mitchell A.) Frontiers in Cell and Developmental Biology. 23 June 2020;8 SCOPUS ID: 2-s2.0-85087475806 06/23/2020

Cardiovascular Center

Geurts Lab

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