Geurts Lab
Aron Geurts, PhD
Principal Investigator
Associate Professor, Department of Physiology
ageurts@mcw.edu
Dr. Geurts is an Associate Professor in the Department of Physiology, Cardiovascular Research Center and Genomic Sciences and Precision Medicine Center. He leads an NIH-funded research team focused on innovating novel approaches to genetic engineering and creating animal and cell models of complex genetic human diseases. He is a recipient of a prestigious New Innovator award from the Office of the Director of the NIH.
Michael Grzybowski
Laboratory Supervisor
mgrzybowski@mcw.edu
My role in Dr. Aron Geurts' lab is to help facilitate the creation of genetically modified models. I design nuclease reagents that are then created and validated in the Geurts lab that will be used to create these modifications. I am also responsible for the day to day operations in the lab. My research interests are mainly molecular biology and technology and how to create and develop animal models.
Akiko Takizawa
Research Scientist II
atakizawa@mcw.edu
My research interests are related to reproductive biology in rats. I am especially interested in assisted reproductive technology such as cryopreservation of gametes and zygotes, re-derivation and embryo manipulation. These technologies are reliable methods to preserve strains which were generated using new gene modification technologies such as Zinc Finger Nucleases (ZFNs) and TAL Effector Nucleases (TALENs), to avoid breeding problems. I am also interested in the development of more effective sperm cryopreservation and nuclear transfer technology.
Jason Klotz
Research Technologist III
jklotz@mcw.edu
Under Dr. Geurts I help coordinate the business conducted in the Rat Transgenic Service Center. I also perform micro-injections and sperm cryopreservation for the Service Center.
Recent Publications
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(Paterson MR, Geurts AM, Kriegel AJ.) Kidney Int. 2019 Dec;96(6):1332-1345 PMID: 31668631 PMCID: PMC6941490 SCOPUS ID: 2-s2.0-85074541202 11/02/2019
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Knockout of purinergic receptor attenuates cyst growth in a rat model of ARPKD.
(Arkhipov SN, Potter DL, Geurts AM, Pavlov TS.) Am J Physiol Renal Physiol. 2019 Dec 01;317(6):F1649-F1655 PMID: 31630543 PMCID: PMC6960783 SCOPUS ID: 2-s2.0-85075959618 10/22/2019
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Synergistic Genetic Interactions between and Result in an ARPKD-Like Phenotype in Murine Models.
(Olson RJ, Hopp K, Wells H, Smith JM, Furtado J, Constans MM, Escobar DL, Geurts AM, Torres VE, Harris PC.) J Am Soc Nephrol. 2019 Nov;30(11):2113-2127 PMID: 31427367 PMCID: PMC6830782 SCOPUS ID: 2-s2.0-85074378541 08/21/2019
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Habenular TCF7L2 links nicotine addiction to diabetes.
(Duncan A, Heyer MP, Ishikawa M, Caligiuri SPB, Liu XA, Chen Z, Micioni Di Bonaventura MV, Elayouby KS, Ables JL, Howe WM, Bali P, Fillinger C, Williams M, O'Connor RM, Wang Z, Lu Q, Kamenecka TM, Ma'ayan A, O'Neill HC, Ibanez-Tallon I, Geurts AM, Kenny PJ.) Nature. 2019 10;574(7778):372-377 PMID: 31619789 SCOPUS ID: 2-s2.0-85073431118 10/18/2019
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Hepatic pathology and altered gene transcription in a murine model of acid ceramidase deficiency.
(Yu FPS, Molino S, Sikora J, Rasmussen S, Rybova J, Tate E, Geurts AM, Turner PV, Mckillop WM, Medin JA.) Lab Invest. 2019 Oct;99(10):1572-1592 PMID: 31186526 SCOPUS ID: 2-s2.0-85067402206 06/13/2019
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(Xue H, Geurts AM, Usa K, Wang F, Lin Y, Phillips J, Henderson L, Baker MA, Tian Z, Liang M.) Hypertension. 2019 08;74(2):313-322 PMID: 31230549 PMCID: PMC6620137 SCOPUS ID: 2-s2.0-85069627359 06/25/2019
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(Zhang C, He X, Murphy SR, Zhang H, Wang S, Ge Y, Gao W, Williams JM, Geurts AM, Roman RJ, Fan F.) J Pharmacol Exp Ther. 2019 08;370(2):206-217 PMID: 31118214 PMCID: PMC6636243 SCOPUS ID: 2-s2.0-85070025580 05/24/2019
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The p52 isoform of SHC1 is a key driver of breast cancer initiation.
(Wright KD, Miller BS, El-Meanawy S, Tsaih SW, Banerjee A, Geurts AM, Sheinin Y, Sun Y, Kalyanaraman B, Rui H, Flister MJ, Sorokin A.) Breast Cancer Res. 2019 06 15;21(1):74 PMID: 31202267 PMCID: PMC6570928 SCOPUS ID: 2-s2.0-85067234098 06/17/2019
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(Kim J, Martin A, Yee J, Fojut L, Geurts AM, Oshima K, Zimmerman MA, Hong JC.) J Surg Res. 2019 03;235:73-82 PMID: 30691853 SCOPUS ID: 2-s2.0-85055264636 01/30/2019
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MiR-192-5p in the Kidney Protects Against the Development of Hypertension.
(Baker MA, Wang F, Liu Y, Kriegel AJ, Geurts AM, Usa K, Xue H, Wang D, Kong Y, Liang M.) Hypertension. 2019 02;73(2):399-406 PMID: 30595117 PMCID: PMC6339564 SCOPUS ID: 2-s2.0-85059796489 01/01/2019
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Telomerase Deficiency Predisposes to Heart Failure and Ischemia-Reperfusion Injury.
(Ait-Aissa K, Heisner JS, Norwood Toro LE, Bruemmer D, Doyon G, Harmann L, Geurts A, Camara AKS, Beyer AM.) Front Cardiovasc Med. 2019;6:31 PMID: 31001540 PMCID: PMC6454001 04/20/2019
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CD11c Cells Are Gatekeepers for Lymphocyte Trafficking to Infiltrated Islets During Type 1 Diabetes.
(Sandor AM, Lindsay RS, Dyjack N, Whitesell JC, Rios C, Bradley BJ, Haskins K, Serreze DV, Geurts AM, Chen YG, Seibold MA, Jacobelli J, Friedman RS.) Front Immunol. 2019;10:99 PMID: 30766536 PMCID: PMC6365440 SCOPUS ID: 2-s2.0-85061573541 02/16/2019