GettyImages-609179959-hero

Cardiovascular Center

Auchampach Lab

johnauchampach


John A. Auchampach, PhD
Principal Investigator; Professor, Vice Chair, Pharmacology and Toxicology
jauchamp@mcw.edu

Dr. Auchampach is a professor in the Department of Pharmacology. He leads an NIH-funded laboratory focused on ischemic heart disease, cardiac regeneration, and drug development.

Tina Wan

Tina Wan, PhD
Research Scientist
twan@mcw.edu

Our laboratory studies adenosine signaling via its four G protein-coupled receptors during cardiovascular disease. We utilize mice and rats as our model system. I am involved in generating and characterizing new genetic mouse models with global and tissue-specific deletion of specific adenosine receptor subtypes. Other important aspects of my research involve assessing cardiac function (pressure-volume analyses; echocardiography) and conducting surgeries to induce myocardial infarction in rodents. Our laboratory has recently formed a new collaboration with Dr. John Lough in the Department of Cell Biology. The goal of this project using novel genetic mouse models is to test the hypothesis that inhibition of the acetyl transferase Tip60 during myocardial infarction will promote more efficient regeneration by permitting surviving cardiomyocytes to re-enter the cell cycle.

Elizabeth Gizewski

Elizabeth Gizewski, BS
Research Technologist III
egizewsk@mcw.edu

I received my Degree from the University of Wisconsin-Madison. I have been working with Dr. Auchampach’s research group for the past 10 years. My role has been to characterize new synthetic ligands for adenosine receptors utilizing various biochemical assays including radioligand binding, cAMP accumulation, and [35S]GTPγS binding assays. I have made several important contributions to our research program working with research chemists at the NIH and Leiden University in the Netherlands. I have assisted with the development of new selective agonists for the A3 adenosine receptor, which have promise as drug therapy for many different inflammatory disorders and chronic neuropathic pain. I have also contributed to the development and characterization of an exciting new class of ligands for the A3 adenosine receptor called positive A3 adenosine receptor allosteric modulators.

Shraddha Nayak

Shraddha Nayak, BS
Graduate Research Assistant
snayak@mcw.edu

I am a PhD graduate student in the Department of Pharmacology completing my thesis work in Dr. Auchampach’s laboratory. My project involves characterizing a new line of rats in which the A2B adenosine receptor gene has been genetically disrupted using the zinc finger nuclease strategy. The rat line was created on the Dahl salt-sensitive genetic background. My work has led to better understanding of the participation of A2B adenosine receptor signaling during cardiovascular diseases including hypertension and diabetes.

Recent Publications