Kevin Regner Lab
Kevin R. Regner, MD, MS, FASN
Chief and Professor, Department of Medicine
kregner@mcw.edu
The primary goal of the Regner laboratory is to investigate the cellular, molecular, and genetic mechanisms involved in ischemic acute kidney injury (AKI) and kidney repair.
Current projects include:
1. Activator of G Protein Signaling 3 in Ischemic Renal Injury. The objective of this study is to characterize the role of Activator of G protein signaling 3 (AGS3), a novel non-receptor regulator of G-protein function, in renal tubular regeneration following ischemic AKI.
2. Genetic mapping and gene identification for acute kidney injury in outbred rats. The objective of this study is to identify novel genes that modulate susceptibility or resistance to AKI using a novel genetic resource, heterogeneous stock rats.
Bohan Xing, BS
Research Technologist Ibxing@mcw.edu
Utilizing the murine model of renal ischemia-reperfusion injury, Bohan characterizes renal injury using molecular and biochemical assays and histological analysis.
Recent Publications
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(Miller B, Regner K, Sorokin A.) Biochemical and Biophysical Research Communications. 7 May 2022;603:69-74 SCOPUS ID: 2-s2.0-85125835040 05/07/2022
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(Belcher JM, Parada XV, Simonetto DA, Juncos LA, Karakala N, Wadei HM, Sharma P, Regner KR, Nadim MK, Garcia-Tsao G, Velez JCQ, Parikh SM, Chung RT, Allegretti AS, HRS-HARMONY Study Investigators.) Am J Kidney Dis. 2022 May;79(5):737-745 PMID: 34606933 SCOPUS ID: 2-s2.0-85122545748 10/05/2021
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(Williams AM, Jensen DM, Pan X, Liu P, Liu J, Huls S, Regner KR, Iczkowski KA, Wang F, Li J, Gallan AJ, Wang T, Baker MA, Liu Y, Lalehzari N, Liang M.) Kidney Int. 2022 04;101(4):766-778 PMID: 35114200 PMCID: PMC8940673 SCOPUS ID: 2-s2.0-85125312317 02/04/2022
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(Swanson ML, Regner KR, Moore BM, Park F.) Cannabis Cannabinoid Res. 2022 Feb 23 PMID: 35196117 02/24/2022
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DNA damage is overcome by TRIP13 overexpression during cisplatin nephrotoxicity.
(Hama T, Nagesh PK, Chowdhury P, Moore BM 2nd, Yallapu MM, Regner KR, Park F.) JCI Insight. 2021 11 22;6(22) PMID: 34806647 PMCID: PMC8663775 SCOPUS ID: 2-s2.0-85120382452 11/23/2021
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(Allegretti AS, Parada XV, Endres P, Zhao S, Krinsky S, St Hillien SA, Kalim S, Nigwekar SU, Flood JG, Nixon A, Simonetto DA, Juncos LA, Karakala N, Wadei HM, Regner KR, Belcher JM, Nadim MK, Garcia-Tsao G, Velez JCQ, Parikh SM, Chung RT, HRS-HARMONY study investigators.) Clin Transl Gastroenterol. 2021 05 11;12(5):e00359 PMID: 33979307 PMCID: PMC8116001 SCOPUS ID: 2-s2.0-85105838703 05/13/2021
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DNA damage is overcome by TRIP13 overexpression during cisplatin nephrotoxicity
(Hama T, Nagesh PKB, Chowdhury P, Moore BM, Yallapu MM, Regner KR, Park F.) JCI Insight. 22 November 2021;6(22) SCOPUS ID: 2-s2.0-85120382452 11/22/2021
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Endogenous miR-204 Protects the Kidney against Chronic Injury in Hypertension and Diabetes.
(Cheng Y, Wang D, Wang F, Liu J, Huang B, Baker MA, Yin J, Wu R, Liu X, Regner KR, Usa K, Liu Y, Zhang C, Dong L, Geurts AM, Wang N, Miller SS, He Y, Liang M.) J Am Soc Nephrol. 2020 07;31(7):1539-1554 PMID: 32487559 PMCID: PMC7350998 SCOPUS ID: 2-s2.0-85087468924 06/04/2020
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MicroRNA-214-3p in the Kidney Contributes to the Development of Hypertension.
(Liu Y, Usa K, Wang F, Liu P, Geurts AM, Li J, Williams AM, Regner KR, Kong Y, Liu H, Nie J, Liang M.) J Am Soc Nephrol. 2018 10;29(10):2518-2528 PMID: 30049682 PMCID: PMC6171279 SCOPUS ID: 2-s2.0-85053979457 07/28/2018
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Urinary exosomal expression of activator of G protein signaling 3 in polycystic kidney disease.
(Keri KC, Regner KR, Dall AT, Park F.) BMC Res Notes. 2018 Jun 07;11(1):359 PMID: 29880041 PMCID: PMC5992714 SCOPUS ID: 2-s2.0-85048187272 06/09/2018
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Artificial intelligence, physiological genomics, and precision medicine.
(Williams AM, Liu Y, Regner KR, Jotterand F, Liu P, Liang M.) Physiol Genomics. 2018 04 01;50(4):237-243 PMID: 29373082 PMCID: PMC5966805 SCOPUS ID: 2-s2.0-85046104804 01/27/2018
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Tissue-Specific MicroRNA Expression Patterns in Four Types of Kidney Disease.
(Baker MA, Davis SJ, Liu P, Pan X, Williams AM, Iczkowski KA, Gallagher ST, Bishop K, Regner KR, Liu Y, Liang M.) J Am Soc Nephrol. 2017 Oct;28(10):2985-2992 PMID: 28663230 PMCID: PMC5619963 SCOPUS ID: 2-s2.0-85030470491 07/01/2017