Michael E. Widlansky Lab | Cardiovascular Center

Michael Widlansky Lab

Michael Widlansky, MD, MPH

Michael E. Widlansky, MD, MPH
Professor, Department of Medicine
Principal Investigator
mwidlans@mcw.edu

The Widlansky laboratory work is currently focused on the roles of mircroRNA-29, mitochondrial fission proteins, and the microbiome in the regulation of human vascular endothelial function. It also focuses on studying novel mechanisms of vascular dysfunction in diabetes. His work tests these novel mechanistic insights to determine their relevance to human vascular pathophysiology. In addition, the Widlansky laboratory studies the impact of dietary, pharmacological, and exercise-based interventions on vascular function persons with and without disease. The laboratory also has formed a human vascular research core to foster collaboration with investigators from other disciplines interested in the impact of vascular function on disease states relevant to their fields of interest.

Meet Our Team

Amberly Anger

Program Manager I

aanger@mcw.edu

Nabeel Khan, MD

Assistant Professor

Rachel Schneider

Clinical Research Assistant II

raschneider@mcw.edu

(414) 955-6753

Molly Siegel

Clinical Research Coordinator I

msiegel@mcw.edu

(414) 955-6759

Jingli Wang, MD, PhD

Research Scientist II

jiwang@mcw.edu

(414) 456-6777

Justin Westhoff

Research Technologist I

jwesthoff@mcw.edu

(414) 955-7436

Rong Ying, MD

Research Technologist II

riying@mcw.edu

(414) 456-7436

Alumni/Former Trainees

Benjamin Hofeld
Mobin Malik
V. K. Puppala
Tisha Suboc
Mike Tanner
Sudhi Tyagi

Abnormal hearing patterns are not associated with endothelium-dependent vasodilation and carotid intima-media thickness: The Framingham Heart Study.

(Tyagi S, Friedland DR, Rein L, Tarima SS, Mueller C, Benjamin EJ, Vasan RS, Hamburg NM, Widlansky ME.) Vasc Med. 2021 Dec;26(6):595-601 PMID: 34286655 SCOPUS ID: 2-s2.0-85111029673 07/22/2021
Dietary Sodium Restriction Results in Tissue-Specific Changes in DNA Methylation in Humans.

(Kidambi S, Pan X, Yang C, Liu P, Roberts ML, Li Y, Wang T, Laud PW, Liu Y, Rubens M, Thomas R, Widlansky ME, Beyer AM, Liu Y, Cowley AW Jr, Kotchen TA, Munyura Y, Moosreiner A, Mattson DL, Liang M.) Hypertension. 2021 08;78(2):434-446 PMID: 34120454 SCOPUS ID: 2-s2.0-85109563974 06/15/2021
The impact of standing desks on cardiometabolic and vascular health.

(Bodker A, Visotcky A, Gutterman D, Widlansky ME, Kulinski J.) Vasc Med. 2021 08;26(4):374-382 PMID: 33813968 SCOPUS ID: 2-s2.0-85103654778 04/06/2021
Lactobacillus plantarum 299v probiotic supplementation in men with stable coronary artery disease suppresses systemic inflammation.

(Hofeld BC, Puppala VK, Tyagi S, Ahn KW, Anger A, Jia S, Salzman NH, Hessner MJ, Widlansky ME.) Sci Rep. 2021 02 17;11(1):3972 PMID: 33597583 PMCID: PMC7889883 SCOPUS ID: 2-s2.0-85101105180 02/19/2021
Mitochondrial Fission Protein 1: Emerging Roles in Organellar Form and Function in Health and Disease.

(Ihenacho UK, Meacham KA, Harwig MC, Widlansky ME, Hill RB.) Front Endocrinol (Lausanne). 2021;12:660095 PMID: 33841340 PMCID: PMC8027123 SCOPUS ID: 2-s2.0-85103798701 04/13/2021
Pacemaker detected active minutes are superior to pedometer-based step counts in measuring the response to physical activity counseling in sedentary older adults.

(Puppala VK, Hofeld BC, Anger A, Tyagi S, Strath SJ, Fox J, Berger MG, Ahn KW, Widlansky ME.) BMC Geriatr. 2020 05 06;20(1):162 PMID: 32375676 PMCID: PMC7201960 SCOPUS ID: 2-s2.0-85084386697 05/08/2020
Pandemic Perspective: Commonalities Between COVID-19 and Cardio-Oncology.

(Brown SA, Zaharova S, Mason P, Thompson J, Thapa B, Ishizawar D, Wilkes E, Ahmed G, Rubenstein J, Sanchez J, Joyce D, Kalyanaraman B, Widlansky M.) Front Cardiovasc Med. 2020;7:568720 PMID: 33344513 PMCID: PMC7746643 SCOPUS ID: 2-s2.0-85115906217 12/22/2020
Circulating levels of mitochondrial uncoupling protein 2, but not prohibitin, are lower in humans with type 2 diabetes and correlate with brachial artery flow-mediated dilation.

(Kakarla M, Puppala VK, Tyagi S, Anger A, Repp K, Wang J, Ying R, Widlansky ME.) Cardiovasc Diabetol. 2019 11 09;18(1):148 PMID: 31706320 PMCID: PMC6842161 SCOPUS ID: 2-s2.0-85074741922 11/11/2019
Contrast-enhanced ultrasound detects changes in microvascular blood flow in adults with sickle cell disease.

(Lindner JR, Belcik T, Widlansky M, Harmann LM, Karafin MS, Wandersee NJ, Puligandla M, Neuberg D, Linden J, Field JJ.) PLoS One. 2019;14(7):e0218783 PMID: 31276520 PMCID: PMC6611596 SCOPUS ID: 2-s2.0-85069268459 07/06/2019
Mitochondrial regulation of diabetic vascular disease: an emerging opportunity.

(Widlansky ME, Hill RB.) Transl Res. 2018 12;202:83-98 PMID: 30144425 PMCID: PMC6218302 SCOPUS ID: 2-s2.0-85052836555 08/26/2018
Lactobacillus plantarum 299v Supplementation Improves Vascular Endothelial Function and Reduces Inflammatory Biomarkers in Men With Stable Coronary Artery Disease.

(Malik M, Suboc TM, Tyagi S, Salzman N, Wang J, Ying R, Tanner MJ, Kakarla M, Baker JE, Widlansky ME.) Circ Res. 2018 10 12;123(9):1091-1102 PMID: 30355158 PMCID: PMC6205737 SCOPUS ID: 2-s2.0-85055600525 10/26/2018
Tissue-specific effects of targeted mutation of Mir29b1 in rats.

(Xue H, Zhang G, Geurts AM, Usa K, Jensen DM, Liu Y, Widlansky ME, Liang M.) EBioMedicine. 2018 Sep;35:260-269 PMID: 30120082 PMCID: PMC6156712 SCOPUS ID: 2-s2.0-85051562841 08/19/2018

Cardiovascular Center