Archived News from the Ocular Gene Therapy Laboratory
|December 4, 2017
Publication – Chris Reid and Kristina Ertel have an article published in the journal Investigative Ophthalmology and Visual Science
Chris Reid, a final year graduate student in the IDP program, and Kristina Ertel, a former research technologist in the Ocular Gene Therapy Laboratory, recently published an article describing a recombinant adeno-associated virus vector with significantly improved photoreceptor targeting following intravitreal injection. The study demonstrates that capsid modifications with different mechanisms of action can be combined into a single capsid, leading to an additive increase in tissue penetrance and cellular uptake. The resulting vector, termed rAAV2/2[MAX], is currently being trialled by several OGTL collaborators and is available upon request. Read the full article
|July 10, 2017
Welcome – Emily Nettesheim joins OGTL as a Research Technologist
Emily Nettesheim, who recently received Bachelors degrees (BS) in both Anthropology and Molecular Biology from the University of Madison, Wisconsin, will join OGTL as a research Technologist. Emily will be responsible for assisting the everyday running of the lab, in addition to conducting her own research project focused on the design of novel viral vectors with large coding capacity for retinal gene delivery.
July 5, 2017
Welcome – Dwani Patel joins OGTL as a graduate student
Dwani Patel, a MD/PhD student in the Medical Scientist Training Program (MSTP), has joined the OGTL under the supervision of Dr Daniel Lipinski, DPhil, on a full time basis to undertake his doctoral research. Dwani will be focusing on the development of strategies to target gene delivery to retinal vascular endothelial cells and pericytes, cell types that are implicated in the development of sight - threatening complications associated with diabetes.
|June 15, 2017
Publication – Chris Reid has article accepted to Gene Therapy
Chris Reid, a fourth year graduate student, publishes an article in Gene Therapy detailing a methodology to improve recombinant adeno-associated virus (rAAV) vector yield through silencing of transgene expression during virus manufacture. Co-authors on the study include William Hauswirth, PhD, Professor of Ophthalmology, and Sanford Boye, MS, Associate Scientist, both at the University of Florida. Read the full article
April 19, 2017
Intravitreal transduction profile of recombinant adeno-associated virus in murine and human retina
March 13, 2017
Reid, C., Lipinski, D.M.
| March 10, 2017
Congratulations – Kristina Ertel is accepted to graduate school
Kristina Ertel, currently a research technologist in the Lipinski Laboratory, has been accepted to the Medical College of Wisconsin Interdisciplinary Biomedical Sciences Doctoral Program (IDP). Beginning in August 2017, Kristina will be joining a class of approximately 20 promising doctoral candidates. The whole of the OGTL program wishes Kristina the best of luck in her future endeavours!
|March 1, 2017
Welcome – Hanmeng Zhang joins the Lipinski Lab as a graduate student
Hanmeng Zhang, a second year graduate student in the Neuroscience Doctoral Program (NDP), has elected to join the Lipinski Laboratory full time to carry out research towards her graduate thesis. Hanmeng will primarily be working on developing novel therapies to prevent cone photoreceptor degeneration in retinitis pigmentosa, a disease that causes severe visual impairment in approximately 1 in 4000 individuals worldwide