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Ocular Gene Therapy Laboratory

Archived News from the Ocular Gene Therapy Laboratory

2020 News

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 April 28, 2020

Publication – OGTL research published in Scientific Reports
In an article published today, Dwani Patel, a graduate student from the Lipinski Laboratory, describes the fundamental principles of laser speckle contrast imaging (LSCI) and its application for assessing the function of blood vessels within the retina.

In this manuscript, Dwani modified a commercial fundus camera to image the retina with coherent laser light and demonstrated that generation of speckle interference is dependent on movement of blood within a vessel and that the degree of speckle blurring is proportional to flow rate. 

The ability to accurately measure hemodynamic changes within the retina using LSCI represents an exciting diagnostic and therapeutic advancement, potentially allowing for the progression of diseases exhibiting vascular pathologies, such as diabetes or Alzheimer’s, to be assessed non-invasively before and after treatment. 

Read the full article.

 Headshot_Dwani Patel_Square February 28, 2020
Congratulations – Dwani Patel receives travel grant for the upcoming Association for Research in Vision and Ophthalmology (ARVO) annual meeting
Dwani Patel, a third year MSTP student in the Ocular Gene therapy Laboratory (OGTL) has been awarded the ‘David R. Pepperberg Travel Grant’ to attend the ARVO annual meeting, held 3rd – 7th May, 2020 in Baltimore, MD. Dwani will present his poster entitled ‘Identifying novel retinal pericyte-targeting rAAV mutant vectors through directed evolution’ on May 6th, 3.00 – 4.45pm (B0129). 
 Headshot_Rachel Fehrman_square February 10, 2020
Welcome – Rachel Fehrman joins OGTL as a graduate student
Rachel Fehrman, a first-year graduate student in the interdisciplinary program (IDP), has elected to join the Lipinski Laboratory full time to complete her graduate studies. Rachel will be working to develop gene therapy vectors capable of delivering large genes to the retina and characterize zebrafish models of rare inherited retinal disease.