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Vascular and Endovascular Surgery

Dyer Research Laboratory

Versiti Blood Research Institute

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Mission Statement

Advance the understanding of the mechanisms driving thrombo-inflammation and development of post-surgical and post-injury blood clots.

Mitchell Dyer, MD, MSc
Assistant Professor of Surgery and Radiology
Adjunct Associate Investigator, Versiti Blood Research Institute
(414) 955-1800

Research Summary

The goal of Dr. Dyer’s laboratory is to understand the mechanisms that drive the interplay between the coagulation system and inflammatory system and how those interactions contribute to the development of pathophysiologic blood clots. Animal models of deep venous thrombosis, polytraumatic injury, and traumatic brain injury in mice and swine and novel RNA therapies (siRNA and mRNA) are harnessed as a biological tool to gain a greater understanding of the mechanisms regulating thrombo-inflammation. These novel RNA therapies serve not only as biological tools but are then evaluated for efficacy in preventing unwanted thrombosis.

Funding Support

  • NIH/NHLBI K08 Career Development Award-K08HL177422
  • Society for Vascular Surgery
  • Department of Defense-HT9425-24-1-0942
  • Department of Defense-Award # TBD starting 7/2026

Lab Members

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Manoj Paul, PhD

Postdoctoral Researcher

manpaul@mcw.edu

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Sarah Fisher, MD

Indiana University School of Medicine

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Anna Johnson

Research Technician I

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