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Postdoctoral Research Opportunities

Postdoctoral Fellow Position to Study Transcriptional Regulation of Liver Development and Metabolic Function

A postdoctoral research position is available in the Cirillo laboratory for a highly motivated individual interested in research that investigates how chromatin structure directs transcriptional regulation of liver development and metabolism. The Cirillo lab studies the diverse chromatin binding and remodeling abilities of pioneer DNA-binding factors, which are the first to engage compacted, transcriptionally silent genes during organ development. Current projects in the lab use novel human stem cell-based hepatocyte differentiation models to investigate the role of one of these factors, FoxO1, in the chromatin opening events required for liver specification in the embryo and recruitment of additional chromatin regulators required to activate the expression of metabolic genes that inform liver function. Knowledge gained from the proposed work will provide new mechanistic insights for tackling human liver disease and cancer and reveal prospective targets for novel, epigenetic-based approaches to treat pervasive human metabolic disorders.

Candidates should have a PhD in Cell and Molecular Biology or a related field. Successful applicants will have extensive knowledge of cell and molecular biology techniques required for analysis of DNA, RNA, and protein in tissues and cultured cells. Experience with genome-wide analysis of transcriptional regulation (RNA- and ChIP-seq) and the analysis of large datasets is desirable. Applicants with experience in stem cell biology, including the culture and differentiation of human ES and iPS cells are strongly encouraged to apply. Strong oral and written communication skills and the ability to think and work independently are essential. Opportunities are available for presentations at national and international scientific conferences and for applying for independent funding. Interested individuals should email a CV, a description of research interests, and the names and contact information for three references to Dr. Lisa Cirillo at lcirillo@mcw.edu.

Lisa Ann Cirillo
Associate Professor
Department of Cell Biology, Neurobiology, and Anatomy
Assistant Dean, Basic Science Curriculum
Medical College of Wisconsin
8701 Watertown Plank Rd.
Milwaukee, WI 53226

(414) 955-4694 | (414) 955-6517 (fax) | lcirillo@mcw.edu
Affirmative Action/Equal Opportunity Employer

Postdoctoral Fellow Position to Study Pain and Touch at the Medical College of Wisconsin (MCW) in Milwaukee, Wisconsin 

Starting Date: As soon as possible

Salary: NIH Scale

Team Stucky seeks a highly motivated postdoctoral research fellow to lead studies related to one or more of our exciting research areas including 1) roles of keratinocytes and other non-neuronal cells in touch and thermal detection after tissue injury, 2) mechanisms driving acute and chronic pain in Fabry disease, a lysosomal storage disease, 3) causes of acute and chronic pain in sickle cell disease, 4) roles of the inflammasome in chronic pain, and 5) molecular mechanisms that underlie migraine headache. To research these topics, the Stucky Lab uses a variety of approaches including optogenetics, spontaneous and evoked animal behavior, patch clamp electrophysiology, in vivo and ex vivo teased fiber electrophysiology, calcium imaging, sniffer cells, biomolecular probes and top down mass spectroscopy. Translational projects are available and collaboration and communication with clinicians from the major adjacent hospitals occurs within the lab regularly. Team Stucky is highly interactive and has multiple ongoing collaborations with other labs in various departments at MCW and at other institutes. We seek PhDs who are highly motivated, mature, and possess excellent interpersonal skills and writing skills. Opportunities are available for presentations at national and international scientific conferences and for applying for independent funding. Team Stucky has a strong track record of both postdoctoral fellows and graduate students being awarded their own competitive NIH funding.

Candidates should have a PhD in neuroscience or related biomedical science field. Experience in molecular biology, immunology or electrophysiology is desired; interest in learning electrophysiology is required.

Please submit a letter of interest and curriculum vitae with contact information for at least three references to Dr. Cheryl Stucky at cstucky@mcw.edu.

Visit the Stucky laboratory website

Transcriptional Regulation of GI Development and Function

A postdoctoral research position is available in the Battle laboratory for a highly motivated, ambitious candidate interested in contributing to research to understand mechanisms of transcriptional regulation of gastrointestinal development, function, and disease. Projects in the lab focus on how transcription factors establish boundaries in the GI tract, how transcription factors regulate early aspects of GI development, and how these mechanisms relate to diseases such as short bowel syndrome, Barrett’s esophagus, and esophageal adenocarcinoma. The successful applicant will have experience in cell, developmental, and/or molecular biology. Experience with techniques including Southern blotting, qRT-PCR, Affymetrix gene arrays, RNA-Seq, ChIP-Seq, histology, immunohistochemistry, and immunofluorescence would be beneficial. Experience with animal handling is also desired. Applicants with experience in stem cell biology are also encouraged to apply as we are expanding our research program to stem cell based approaches to study GI development and disease. Excellent communication skills are essential. Interested individuals should email, mail, or fax a CV, description of research ideas and interests, career goals, and the names of three references to:

Michele A. Battle, PhD 
Associate Professor
Department of Cell Biology, Neurobiology, and Anatomy
Medical College of Wisconsin
8701 Watertown Plank Rd. 
Milwaukee, WI 53226

(414) 955-8089 | (414) 955-0124 (fax) | mbattle@mcw.edu

Affirmative Action/Equal Opportunity Employer