About the Genomic Sciences and Precision Medicine Center
The Genomic Sciences and Precision Medicine Center at MCW has its roots in the launch of the Human Genome Project and the 1999 founding of the MCW Human and Molecular Genetics Center. The center uses state-of-the-art sequencing technologies for clinical diagnoses and within its research portfolio to investigate how gene variants impact expression, define genetic variants associated with both rare and common disease, embryonic development, and the effects of environmental factors and drugs upon gene expression and disease. These studies are facilitated through gene engineering in animal models of human disease, bioinformatics resources including genome analysis tools, data standardization, and data integration of multiple data domains for both clinical human data and animal model research. The GSPMC currently consists of 24 faculty members from both basic science (Physiology; Cell Biology, Neurobiology and Anatomy; Institute for Health & Equity) and clinical departments (Pediatrics, Surgery, Medicine, and Obstetrics and Gynecology). This discovery research is funded through NIH research grants and provides a superb training ground for young basic and clinical investigators.
The GSPMC basic and clinical scientists lead the efforts at the Medical College of Wisconsin to provide quality precision medicine and health care by enabling researchers and clinicians to use genomic sequencing to understand disease, improve diagnosis and advance the treatment of our patients. Our laboratory offers CAP, CLIA-certified testing and data analysis for precision diagnostics and therapeutics in pediatric and adult patients.
GSPMC Mission Statement
Leading quality precision medicine and health care by enabling researchers and clinicians to use the genome sequence to understand disease, improve diagnosis and advance patient care.
How to Get Involved
Each of the 10 Academic Programs has an appointed Associate Director, whose role is to form and lead thematic academic membership groups for research and practice. The goal of these Academic Programs is the help researchers adopt interest and advancement in the field of Genomic Sciences and Precision Medicine; however, from these groups of researchers, the center will identify the strongest new scientists in each of these fields and support and lead them to extramural funding opportunities.
Each of the 5 Practice Integration specialty groups has an appointed Medical Director, whose role is to act as a conduit between specialty groups of physicians practicing medicine and conducting clinical research within our Froedtert Health and Children’s Hospital of Wisconsin partners. Whereas other health care providers in the area rely on sending out laboratory testing, MCW and GSPMC make not only in-house testing available to its practicing faculty, but also provide a bridge and platform on which they can interface with bioinformaticians, experts in technology, assay-design, and sequencing, and business and molecular pathology reimbursement professionals. The goal of these Practice Integration groups is to connect practitioners with advanced technology resources to design and customize Precision Medicine tools to innovate their practice and optimize their patient care, all while keeping the experience and care of their patients and clinical research subjects in mind—from sample submission to reimbursement to maximum out-of-pocket expense.
These groups will collaborate with GSPMC professionals to facilitate targeted studies to improve the practice of precision medicine in their specific practice groups. For example, if practitioners identify potential inefficiencies or inadequacies in the test ordering processes for a subset of patients, they could initiate a targeted study and meet with GSPMC professionals to customize a test that focuses on the data these practitioners deem most critical, be informed of the best reimbursement approach to minimize the patient’s out-of-pocket expense, and conduct a value assessment to aid in and empower decision-making processes e.g. the custom test may cost $200 more out-of-pocket, but has the potential to cut three weeks off of the typical test ordering processes.