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About the Medical College of Wisconsin Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Medicine

The Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Medicine (Mellowes Center) at the Medical College of Wisconsin (MCW) works daily to transform the practice of precision medicine by advancing our understanding of diseases, revolutionizing how diseases are diagnosed, and personalizing treatments for patients in our community and beyond.

About the MCW Mellowes Center

Advancing Discovery Through Collaboration and Innovation

The John and Linda Mellowes Center for Genomic Sciences and Precision Medicine continues to serve as a collaborative hub for discovery, innovation, and translational research in genomics, precision medicine, rare diseases, and cancer. By integrating expertise across basic science, clinical research, bioinformatics, genome sciences, and therapeutic development, the Center supports transformative research that advances both scientific understanding and patient care.

As the Center enters its next chapter, we remain committed to fostering interdisciplinary partnerships across the Medical College of Wisconsin and beyond. Through close collaboration with departments, institutes, centers, and the Office of Research, we continue expanding access to advanced genomics, multi-omics, and data science technologies that empower investigators to accelerate discovery and translate research findings into meaningful clinical impact.

The Mellowes Center is currently engaged in an exciting period of growth and strategic evolution. The search for the Center’s next Director represents an opportunity to further strengthen its identity as a premier destination for innovative, high-impact precision medicine research, while building on a strong foundation of scientific excellence, collaboration, and integrity.

Mellowes Center Pillar Programs

Nationally and internationally known for its pioneering work in the fields of ’Omics, Data Science, and Systems Biology, the Center discovers and innovates across its four pillar programs:

Inherited Diseases of Children and Adults

Collaborating with national and international researchers, clinicians, patients and students, the Mellowes Center seeks to advance multidisciplinary research, offering 'Omics and Bioinformatics services and discovering the pivotal role of specific genes in inherited rare diseases.

Learn about inherited diseases research

Community & Precision Public Health

Our commitment to diversifying genomic research focuses on community-based, genomics-informed studies that integrate ethnic diversity and environmental impacts.

Learn about precision public health

Precision Oncology & Cancer Genomics

By studying the genetic, epigenetic, and environmental factors influencing cancer we seek to personalize care and improve prevention, diagnosis, and treatment, and leverage precision medicine in our partnerships with the MCW Cancer Center and Michaels Rare Cancers Research Laboratories.

Learn about precision cancer genomics

Systems Biology Resources in 'Omics and Bioinformatics

We advance precision medicine by developing and adapting novel technologies and methodologies for reliable genetic and epigenetic data analysis, offering state-of-the-art shared resources in 'Omics and Bioinformatics led by experienced teams.

Learn about systems biology resources

To make these advancements possible, the Center boasts multiple state-of-the-art next generation sequencing technologies with supporting expertise in tissue, sample, and analyte processing. Our faculty use these capabilities to investigate how inter-individual variations (i.e. genetic, structural, gene expression, gene regulation, and more) impact cellular and physiologic programs across rare and common diseases, cancers, embryonic development, and the effects of environmental factors and therapeutic treatments. We also have a long-standing advanced program that leverages these technologies with structural bioinformatics to mechanistically define the underpinnings for genetic variants associated with undiagnosed congenital diseases and human cancers.

Mellowes Center Guiding Principles

Discovery & Invention

Discovery & Invention

Genomic sciences and precision medicine exists on the leading edge of research as a driver that rapidly translates to meet clinical needs. We embrace the discovery and invention of ideas, approaches, and tools in order to achieve our Center’s mission. We continuously seek innovative ideas, pursue novel solutions, and test technological advances so that we can be leaders and educators across all units and areas of expertise.

Teamwork

Teamwork

We embrace a shared leadership structure. We celebrate that pioneering the fields of ‘Omics, Data Science, and Systems Biology requires individual and collective excellence and that we can do far more together than we could do alone. We proactively partner to formulate how to move forward amidst challenges. We value each other’s area expertise and strive to invite and facilitate each person to unleash their full creative potential.

Diversity and Inclusion

Diversity and Inclusion

Precision medicine is built upon the knowledge that each individual is unique and diverse, all the way down to the molecular level. We apply this principle to our work environment and commit to not only recognizing but also seeking and including diverse identities, backgrounds, abilities, and perspectives. It is these differences that broaden our ideas, strengthen the way that we work, and increase not only the quality but also the impact of the outcomes of that work. We embrace the mindset of lifelong learners and approach our differences with kind curiosity and openness. We choose the temporary discomfort of discussing differences over the long-term and damaging consequences of ignoring them.

Professionalism

Professionalism

We strive to exemplify Mellowes Center professionalism standards by being mindful, introspective, and resilient. We aim to identify assertions so they can be assessed. We assume positive intent, ask proactive questions, and initiate growth-oriented dialogue with others. We work hard together to excel in our conduct while we achieve our goals. We are resilient in the face of constructive feedback and embrace a culture of kind accountability.

Community

Community

We belong to our unit/lab, the Mellowes Center, the Medical College of Wisconsin, and the broader local, regional, and global communities. We demonstrate our commitment to each of these communities by participating in various engagement opportunities that also advance our goals, mission, and vision. We are stewards of our culture within and beyond our Center and build strong, cooperative relationships. We serve as a community to achieve something larger than ourselves.

Mellowes Center 2024 Annual Report

Contents:

  • A Message from the Director
  • From Genomics to Precision Medicine: The Birth of the Mellowes Center
  • Narrative Medicine in Partnership with Harmony4Hope
  • Mellowes Center Symposium
  • International Collaborations – Impacting Health Around the World
  • Four Pillar Programs Emphasized at the Mellowes Center
  • Driving Impact Through Generosity and Strategic Funding
  • Our Commitment to Education and the Community
  • Technology & Innovation
  • Center Leadership Profiles

View the Mellowes Center 2024 Annual Report (PDF)

Mellowes Center Annual Report 2024
Linda T. Mellowes, Dr. Raul Urrutia, and John A. Mellowes

Mellowes Center History

From its roots in understanding and manipulating model organisms, our Center helped establish a premier NIH-funded database for genetic, genomic, phenotype, and disease-related model organism data management program generated from research (RGD and Alliance of Genome Resources) and pioneered the first-in-the-world breakthrough using whole genome sequencing to diagnose a young boy with a rare disease (One in a Billion).

Now, the reimagined Mellowes Center adapts innovative and cutting edge technology and applies them in our pillar programs to better understand and diagnose rare diseases and rare cancers and improve individual’s knowledge of their own genomic data. These efforts make us the nationally- and internationally-known research hub that we are today.

Contact Us

Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Medicine (Mellowes Center)
Medical College of Wisconsin
8701 Watertown Plank Rd.
Milwaukee, WI 53226

(414) 955-4887
(414) 955-6516 (fax)
mellowescenterinfo@mcw.edu

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