Medical College of Wisconsin
Medical College of Wisconsin Medical College of Wisconsin
Research Bench Lab

Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Medicine

Research

Our diverse team believes that innovation is the key to advancement of understanding, diagnosing, preventing, and treating disease with better outcomes than ever thought possible. Our faculty members have authored hundreds of articles, sit on national and international committees in their areas of expertise, and present locally, nationally, and globally each year. Explore our ongoing research efforts.
Physician researchers collaborating

Programmatic areas of research

  • Precision Medicine
  • Genetics and Genomics
     - Cancer
     - Complex disease (cardiovascular, renal)
     - Immunogenetics
     - Diabetes
     - Obesity
     - Transplantation
     - Metabolic function
  • Epigenetics
  • Physiological Genomics
  • Pharmacogenomics
  • Metabolomics
  • Microbiome/genetics
  • Bioinformatics
  • Biostatistics
  • Gene editing technologies
  • Mutation detection technologies
  • Sequencing, genotyping, expression profiling, biomarker development
  • Genetic Counseling

Additional Research Labs and Services

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Precision Medicine Discovery and Innovation Laboratory ("Disco" Lab)

Led by GSPMC Director and Professor Raul Urrutia, MD, the “Disco Lab” facilitates Team Science-Based Research Collaborations in the areas of genomics, epigenomics, and Precision Medicine. Collaborators throughout MCW and the world are partnered with a team of bioinformaticians with the broad expertise required for integrated and cutting-edge analyses and technologies. 

  • Multi-Omics data integration for an array of high-throughput NGS technologies
  • Batch and Confounder effect assessment & adjustment
  • Knowledge-based modeling
  • Gene network and pathway analysis
  • Molecular Modeling
  • Customized analytic development needed for collaborative science

Learn More about the Precision Medicine "Disco" Lab

Bioinformatics Services & Sciences
The Bioinformatics Analysis Shared Resource at the Mellowes Center is dedicated to providing comprehensive data analytic solutions for a wide variety of researcher areas and experience levels. We deliver comprehensive bioinformatic analysis for DNA and RNA-based sequencing—including scRNA, epigenetic modalities (ChIP, ATAC, etc.)—through interactive web-based reports that include technology-specific quality control metrics, multi-sample comparisons, and advanced analyses beyond current standards in baseline core analysis.  As your trusted partner, we consistently develop and apply custom analyses to meet your program's research and publication needs.
  • Sequencing Performance & Mapping Statistics
  • Multi-component QA/QC, appropriate for each NGS technology
  • Visualization of sample relationships across your cohort(s)
  • SNV, INDEL, and Copy Number Variant (CNV) Analyses
  • Differentially Expressed Genes (DEGs)
  • Epigenetic Profiling (RRBS, ATAC-Seq, ChIP-Seq)
  • Interactive web-based reporting
  • Customized analytic development for collaborative science within the Precision Medicine Discovery and Innovation Laboratory (above)
Rat Research and Model Service Center
Rat ordering information for research.

Learn More

Contact Us

The Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Medicine
Medical College of Wisconsin
8701 Watertown Plank Rd.
Milwaukee, WI 53226

(414) 955-4887
(414) 955-6516 (fax)
gspmcinfo@mcw.edu

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