Drobyski Laboratory
Research Areas
Research in the Drobyski lab is focused on transplantation immunology with a specific emphasis on the immunobiology of allogeneic hematopoietic stem cell transplantation and the pathophysiology of graft versus host disease (GVHD) which is the major complication in patients undergoing this potentially curative therapy. Specifically, the lab seeks to understand the complex interplay between inflammatory and regulatory pathways that become imbalanced during this disease, and develop new mechanistic insights designed to promote the re-establishment of tolerance and amelioration of inflammatory cellular and cytokine-driven pathways. The long-term goal of the lab is to employ a bench to bedside strategy that leads to a reduction in transplant-related morbidity and mortality and thereby improves overall transplant outcomes in patients.
Current research in the lab focuses on: (1) the role of inflammatory cytokines in mediating pathological damage in the gastrointestinal tract which is the major target organ of GVHD, (2) discovery of novel regulatory mechanistic pathways that inhibit alloreactivity and induce tolerance, (3) understanding the mechanisms by which GVHD induces inflammation and cognitive dysfunction in the brain, and (4) the translation of pre-clinical findings into the clinic by devising and implementing rational clinical trials designed to prevent untoward complications arising from this disease.
Current Members
Alison Moe, PhD
Research Scientist II
Aditya Rayasam, PhD
Postdoctoral Fellow
Wenwen Xu, PhD
Postdoctoral Fellow
Cheng- Yin (Vanessa) Yuan
Research Scientist I
Recent Publications
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(Ciecko AE, Schauder DM, Foda B, Petrova G, Kasmani MY, Burns R, Lin CW, Drobyski WR, Cui W, Chen YG.) J Immunol. 2021 Sep 10 PMID: 34507949 09/12/2021
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(Dhakal B, Thapa B, Dong H, Tarima S, Chhabra S, D'Souza A, Drobyski W, Abid M, Shah N, Fenske T, Longo W, Hari P, Hamadani M.) Clin Lymphoma Myeloma Leuk. 2021 Jun 18 PMID: 34257042 SCOPUS ID: 2-s2.0-85110347842 07/15/2021
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(Yuan CY, Zhou V, Sauber G, Stollenwerk T, Komorowski R, López A, Tolón RM, Romero J, Hillard CJ, Drobyski WR.) Blood. 2021 03 04;137(9):1241-1255 PMID: 33027805 PMCID: PMC7933769 SCOPUS ID: 2-s2.0-85101859000 10/08/2020
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(Letscher H, Agbogan VA, Korniotis S, Gastineau P, Tejerina E, Gras C, Mégret J, Moe A, Drobyski WR, Zavala F.) Sci Rep. 2021 Feb 26;11(1):4735 PMID: 33637789 PMCID: PMC7910458 SCOPUS ID: 2-s2.0-85101779771 02/28/2021
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(Knight JM, Costanzo ES, Singh S, Yin Z, Szabo A, Pawar DS, Hillard CJ, Rizzo JD, D'Souza A, Pasquini M, Coe CL, Irwin MR, Raison CL, Drobyski WR.) Transl Psychiatry. 2021 01 18;11(1):58 PMID: 33462203 PMCID: PMC7812704 SCOPUS ID: 2-s2.0-85100097244 01/20/2021
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(Letscher H, Agbogan VA, Korniotis S, Gastineau P, Tejerina E, Gras C, Mégret J, Moe A, Drobyski WR, Zavala F.) Scientific Reports. December 2021;11(1) SCOPUS ID: 2-s2.0-85101779771 12/01/2021
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(Chhabra S, Visotcky A, Pasquini MC, Zhu F, Tang X, Zhang MJ, Thompson R, Abedin S, D'Souza A, Dhakal B, Drobyski WR, Fenske TS, Jerkins JH, Rizzo JD, Runaas L, Saber W, Shah NN, Shaw BE, Horowitz MM, Hari PN, Hamadani M.) Transplantation and Cellular Therapy. 2021 SCOPUS ID: 2-s2.0-85101258094 01/01/2021
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(Luo L, Chen Y, Chen X, Zheng Y, Zhou V, Yu M, Burns R, Zhu W, Fu G, Felix JC, Hartley C, Damnernsawad A, Zhang J, Wen R, Drobyski WR, Gao C, Wang D.) J Immunol. 2020 12 15;205(12):3480-3490 PMID: 33158956 PMCID: PMC7955895 SCOPUS ID: 2-s2.0-85097490484 11/08/2020
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(Sarott RC, Westphal MV, Pfaff P, Korn C, Sykes DA, Gazzi T, Brennecke B, Atz K, Weise M, Mostinski Y, Hompluem P, Koers E, Miljuš T, Roth NJ, Asmelash H, Vong MC, Piovesan J, Guba W, Rufer AC, Kusznir EA, Huber S, Raposo C, Zirwes EA, Osterwald A, Pavlovic A, Moes S, Beck J, Benito-Cuesta I, Grande T, Ruiz de Martı N Esteban S, Yeliseev A, Drawnel F, Widmer G, Holzer D, van der Wel T, Mandhair H, Yuan CY, Drobyski WR, Saroz Y, Grimsey N, Honer M, Fingerle J, Gawrisch K, Romero J, Hillard CJ, Varga ZV, van der Stelt M, Pacher P, Gertsch J, McCormick PJ, Ullmer C, Oddi S, Maccarrone M, Veprintsev DB, Nazaré M, Grether U, Carreira EM.) J Am Chem Soc. 2020 10 07;142(40):16953-16964 PMID: 32902974 SCOPUS ID: 2-s2.0-85092682450 09/10/2020
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(Chhabra S, Visotcky A, Pasquini MC, Zhu F, Tang X, Zhang MJ, Thompson R, Abedin S, D'Souza A, Dhakal B, Drobyski WR, Fenske TS, Jerkins JH, Douglas Rizzo J, Runaas L, Saber W, Shah NN, Shaw BE, Horowitz MM, Hari PN, Hamadani M.) Biol Blood Marrow Transplant. 2020 10;26(10):1876-1885 PMID: 32653622 PMCID: PMC7571859 SCOPUS ID: 2-s2.0-85089134303 07/13/2020
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(Chhabra S, Narra RK, Wu R, Szabo A, George G, Michaelis LC, D'Souza A, Dhakal B, Drobyski WR, Fenske TS, Jerkins JH, Pasquini MC, Rizzo RD, Saber W, Shah NN, Shaw BE, Hamadani M, Hari PN.) Biol Blood Marrow Transplant. 2020 05;26(5):893-901 PMID: 31982543 SCOPUS ID: 2-s2.0-85080146585 01/27/2020
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(Piper C, Zhou V, Komorowski R, Szabo A, Vincent B, Serody J, Alegre ML, Edelson BT, Taneja R, Drobyski WR.) Blood. 2020 02 20;135(8):568-581 PMID: 31880771 PMCID: PMC7033370 SCOPUS ID: 2-s2.0-85081142993 12/28/2019